Epithelial-to-mesenchymal transition is an active process in the large airways of patients with asthma-COPD overlap and partially abrogated by inhaled corticosteroid treatment: a bronchoscopy endobronchial biopsy study [0.03%]
上气道上皮间质转化在哮喘慢性阻塞性肺疾病重叠综合征患者中是一个活跃的过程，吸入性糖皮质激素可部分抑制：一项支气管镜黏膜活检研究
Surajit Dey,Wenying Lu,Prabuddha S Pathinayake et al.
Surajit Dey et al.
Introduction: Asthma and chronic obstructive pulmonary disease (COPD) overlap (ACO) is a term used to describe a patient with coexisting clinical features of asthma and COPD. We have previously reported that epithelial to...
Qirou Wu,Tiejun Zhao,Pinglong Xu
Qirou Wu
Innate immunity comprises intricate cellular and tissue responses critical for host defense and tissue homeostasis. Intercellular communication is central to these responses and significantly influences infection, inflammatory disorders, an...
Tumor-infiltrating lymphocytes in cancer immunotherapy: from chemotactic recruitment to translational modeling [0.03%]
肿瘤浸润淋巴细胞在癌症免疫治疗中的作用：从趋化募集到转化建模
Fatjona Pupuleku Kraja,Vladimir B Jurisic,Altijana Hromić-Jahjefendić et al.
Fatjona Pupuleku Kraja et al.
Tumor-infiltrating lymphocytes (TILs) are a diverse population of immune cells that play a central role in tumor immunity and have emerged as critical mediators in cancer immunotherapy. This review explores the phenotypic and functional div...
Veillonella and Streptococcus are associated with aging of the gut microbiota and affect the efficacy of immune checkpoint inhibitors [0.03%]
韦荣球菌和链球菌与肠道微生物群老化相关并影响免疫检查点抑制剂的疗效
Yuya Hirasawa,Junya Isobe,Masahiro Hosonuma et al.
Yuya Hirasawa et al.
Introduction: The rapid increase in the number of elderly patients with cancer necessitates treatment strategies based on the effects of aging because of drastic side effects of cytotoxic anticancer agents. Immune checkpo...
HMGA2 interacts with KAT6A to regulate MMPs chromatin architecture and promote triple-negative breast cancer metastasis [0.03%]
HMGA2通过调节MMPs染色质结构与KAT6A互作以促进三阴性乳腺癌转移
Lu Qiao,Zenghua Liang,Pengyi Ma et al.
Lu Qiao et al.
Background: Triple-negative breast cancer (TNBC), the most lethal breast cancer subtype, demonstrates poor prognosis due to its high rates of metastasis, recurrence, and mortality. The metastatic potential in TNBC patient...
Immunomodulatory effects of alpha vs beta radiopharmaceutical therapy in murine prostate cancer [0.03%]
α与β放射性药物治疗对小鼠前列腺癌免疫调节作用的影响
Carolina A Ferreira,Hemanth K Potluri,Mojdeh Mahmoudian et al.
Carolina A Ferreira et al.
Background: Radiation therapy can modulate the tumor microenvironment (TME), influencing antitumor immune responses. This study compared the immunomodulatory effects of alpha-emitting (225Ac) and beta-emitting (177Lu) rad...
Single-cell analysis reveals significant transcriptomic alterations in preclinical Crohn's disease [0.03%]
单细胞测序揭示克罗恩病前哨病变中存在显著的转录组变化
Dimitrios Kioroglou,Leire Egia-Mendikute,Asis Palazon et al.
Dimitrios Kioroglou et al.
Despite the increasing incidence of Crohn's disease (CD), its early immune disturbances have not all been described yet. We analysed single-cell RNASeq data from peripheral blood mononuclear cells of patients with incidentally-diagnosed CD,...
Role of extracellular vesicles in cancer: implications in immunotherapeutic resistance [0.03%]
细胞外囊泡在癌症中的作用：对免疫治疗抵抗的启示
Shuai Wang,Zerui Wang,Min Liu et al.
Shuai Wang et al.
Extracellular vesicles (EVs) are lipid membrane-bound vesicles involved in cell-cell communication, particularly in the context of cancer. Immunotherapy, a rapidly evolving field in oncology, is a type of cancer treatment relying on the bod...
CBD promotes antitumor activity by modulating tumor immune microenvironment in HPV associated head and neck squamous cell carcinoma [0.03%]
CBD通过调节HPV相关头颈鳞癌肿瘤免疫微环境发挥抗肿瘤活性
Prakriti Sen,Sayed Sadat,Koji Ebisumoto et al.
Prakriti Sen et al.
Introduction: Marijuana use is associated with HPV-positive head and neck squamous cell carcinoma (HNSCC). However, cannabinoid use continues to increase in the US general population for recreational purposes as well as i...
Expression of PSMD14 in lung adenocarcinoma and its impact on immune cell infiltration and prognosis: a comprehensive analysis based on RNA and single-cell RNA sequencing [0.03%]
PSMD14在肺腺癌中的表达及其对免疫细胞浸润和预后的影响：基于RNA和单细胞RNA测序的综合分析
Jing Zhang,Bohao Sun,Jiabin Lai et al.
Jing Zhang et al.
Background: Lung adenocarcinoma (LUAD) is distinguished by intricate relationships between tumor advancement and the immune microenvironment. The function of PSMD14 (Proteasome 26S Subunit, Non-ATPase 14) within the conte...