NMB promotes the progression of colorectal cancer by regulating the NF-κB/P65 signaling pathway [0.03%]
NMB通过调节NF-κB/P65信号通路促进结直肠癌进展
Jiaxin Fan,Yuming Liu,Jiajia Wang et al.
Jiaxin Fan et al.
Background: Colorectal carcinoma (CRC) ranks as the fourth most prevalent malignancy globally. Neuromedin B (NMB) and its corresponding receptor have been implicated in the pathogenesis of multiple neoplastic conditions. ...
Macrophage regulated cell death: implications and mechanisms in organ transplantation [0.03%]
巨噬细胞调控的细胞死亡在器官移植中的作用及机制
Jincheng Hou,Chenghao Li,Geng Li et al.
Jincheng Hou et al.
Organ transplantation is a critical treatment for end-stage organ failure, but long-term graft survival remains suboptimal due to ischemia-reperfusion injury (IRI) and transplant rejection. The immune microenvironment, especially macrophage...
Treg cell therapy manufacturability: current state of the art, challenges and new opportunities [0.03%]
调节性T细胞治疗的生产工艺：现状、挑战与机遇
Janelle Stoops,Tara Morton,James Powell et al.
Janelle Stoops et al.
Autologous cell therapy is a revolutionary new paradigm in medicine. Significant advancements in personalized therapeutic treatments with engineered T cells have been seen across the immuno-oncology markets. The global market is expanding a...
Changes in immune cell signatures during early infection reflect decoupling of capillary perfusion and glycocalyx dimensions [0.03%]
感染早期免疫细胞特征的变化反映了毛细血管灌注和糖萼尺寸的脱钩
Anna Hunkemöller,Timo Wirth,Alexandros Rovas et al.
Anna Hunkemöller et al.
Introduction: Microvascular injury is central to the pathophysiology of sepsis, but its interaction with the immune system in early infection is unclear. This study aimed to phenotype peripheral blood mononuclear cells (P...
Observational Study
Frontiers in immunology. 2025 May 23:16:1589959. DOI:10.3389/fimmu.2025.1589959 2025
Development of an intranasal, universal influenza vaccine in an EU-funded public-private partnership: the FLUniversal consortium [0.03%]
欧盟资助的公私合作伙伴关系中普遍性流感鼻内疫苗的研发：FLUniversal联盟
Victor M Cnossen,Paula C Leao Moreira,Othmar G Engelhardt et al.
Victor M Cnossen et al.
Influenza is a significant global health problem, causing disease and hospitalisations in elderly individuals and infants. While updated vaccines are available every year, their effectiveness is moderate at best. FLUniversal is a European U...
The predictive value of Naples prognostic score for patients with locally advanced non-small cell lung cancer undergoing surgery after neoadjuvant chemotherapy [0.03%]
那不勒斯预后评分对新辅助化疗联合手术治疗局部晚期非小细胞肺癌患者的价值分析
Yanfei Zhang,Chunyan Tang,Min Yang et al.
Yanfei Zhang et al.
Objective: To evaluate the prognostic significance of the Naples Prognostic Score (NPS) in patients with locally advanced non-small cell lung cancer (NSCLC) after neoadjuvant chemotherapy and surgery. ...
Multiomics analysis unveils key biomarkers during dynamic progress of IAV infection in mice [0.03%]
多组学分析揭示了小鼠IAV感染动态过程中的关键生物标志物
Huan Lei,Yixi Xu,Hao Zhang et al.
Huan Lei et al.
Introduction: Influenza infection is a significant threat to public health, and identifying dynamic biomarkers that influence disease progression is crucial for effective intervention. ...
Thrombospondin-1 mitigates osteoarthritis progression by inhibiting mechanical stress-induced chondrocyte ferroptosis via the integrin/YAP pathway [0.03%]
血小板反应蛋白1通过整合素/YAP途径抑制机械应力诱导的软骨细胞铁死亡从而缓解骨关节炎进展
Shaoyi Wang,Xiaocong Zhou,Fujian Zhang et al.
Shaoyi Wang et al.
Introduction: Osteoarthritis in weight-bearing joints significantly impacts the quality of life in middle-aged and elderly individuals. Abnormal mechanical stress can induce chondrocytes ferroptosis, thereby accelerating ...
Comparative analysis of neutrophil dynamics and disease in SARS-CoV-2 Delta and Omicron variants utilizing an in vivo feline model for COVID-19 [0.03%]
利用猫科动物体内模型比较分析SARS-CoV-2德尔塔和奥密克戎变异株的中性粒细胞动力学及致病情况
Sachithra Gunasekara,Shoroq Shatnawi,Sunil More et al.
Sachithra Gunasekara et al.
Introduction: The emergence of SARS-CoV-2 variants, particularly Delta (B.1.617.2) and Omicron (XBB.1.5) variants, has substantially influenced the clinical and immunological landscape of COVID-19. This study investigates...
Comparative Study
Frontiers in immunology. 2025 May 22:16:1547918. DOI:10.3389/fimmu.2025.1547918 2025
Case Report: Effectiveness of deucravacitinib in chronic recurrent multifocal osteomyelitis and concomitant psoriasis [0.03%]
案例报告：Deucravacitinib治疗慢性复发性多灶性骨髓炎合并银屑病的有效性
Caroline Glatzel,Patrick-Pascal Strunz,Matthias Goebeler et al.
Caroline Glatzel et al.
We present the case of a 22-year-old male who was first diagnosed with chronic recurrent multifocal osteomyelitis (CRMO) at the age of 16 years. During treatment with the tumor necrosis factor (TNF)-alpha inhibitor adalimumab, he developed ...