Case Report: Biliary hemorrhage by intrahepatic pseudoaneurysm and asymptomatic right coronary artery pseudoaneurysm in a patient with STAT3 hyper IgE syndrome [0.03%]
病例报告：STAT3 型高IgE综合征患者的肝内假性动脉瘤性胆道出血伴无症状右冠状动脉假性动脉瘤
Daiki Fujita,Masahiro Ueki,Hiroshi Yamanaka et al.
Daiki Fujita et al.
STAT3-hyper IgE syndrome (STAT3-HIES) is a primary immunodeficiency disorder caused by dominant-negative mutations in STAT3, leading to defects in Th17 cell differentiation, immune regulation, and tissue repair. Patients are susceptible to ...
Construction of stable packaging cell lines for large-scale industrial BaEV-enveloped retroviral vector production [0.03%]
用于大规模生产包被巴尔的摩 enveloped 病毒载体的稳定包装细胞系的构建
Lijun Zhao,Chunting Qiu,Hanyi Chen et al.
Lijun Zhao et al.
Introduction: Viral vectors with Baboon endogenous virus (BaEV) envelope proteins have been demonstrated to markedly increase gene transfer efficiency to NK cells. Nevertheless, the cytotoxicity of the BaEV envelope prote...
Developing an in vitro osteochondral micro-physiological system for modeling cartilage-bone crosstalk in arthritis [0.03%]
一种体外软骨骨微生理系统的发展，用于关节炎软骨-骨通讯的建模
Kyra W Y Smith,Stephanie L Fung,Hsin-Fang Wu et al.
Kyra W Y Smith et al.
Introduction: Arthritis, a disease affecting over 50 million adults in the United States, encompasses many different conditions involving joints and surrounding tissues. Disease development, progression, and subsequent tr...
Editorial: Differential activation of cell death pathways in macrophages as a result of adaptation to divergent microenvironment [0.03%]
述评：适应不同微环境的巨噬细胞促发不同的细胞死亡途径
Krzysztof Guzik,Philippe Saas,David Masson
Krzysztof Guzik
Nonlinearity and sex differences in the performance of a polygenic risk score for juvenile idiopathic arthritis [0.03%]
青春期特发性关节炎多基因评分的表现与性别差异及非线性关系
Kristine Løkås Haftorn,Hamid Khoshfekr Rudsari,Piotr Pawel Jaholkowski et al.
Kristine Løkås Haftorn et al.
Background: Juvenile idiopathic arthritis (JIA) is an immune-mediated pediatric disease believed to result from a complex interplay of genetic and environmental factors. Genome-wide association studies have enabled calcul...
Application and prospects of genetic engineering in CAR-NK cell therapy [0.03%]
基因工程在CAR-NK细胞治疗中的应用及展望
Caidong Hu,Wenhong Lai,Bin Tian et al.
Caidong Hu et al.
With the rapid advancement of genetic engineering technologies, CAR-NK cell therapy, as an emerging immunotherapeutic approach, has demonstrated significant potential. CAR-NK cells recognize and eliminate tumor cells through chimeric antige...
TSLP pretreatment inhibits M1 macrophage polarization and attenuates LPS-induced iNKT cell-dependent acute lung injury [0.03%]
TSLP预处理通过抑制M1型巨噬细胞极化依赖性iNKT细胞活化削弱LPS诱导的急性肺损伤
Ting Zhou,Ziyao Zhang,Yawen Zhan et al.
Ting Zhou et al.
Introduction: Sepsis associated acute respiratory distress syndrome (ARDS), is a life-threatening condition characterized by severe pulmonary inflammation. Previous research has suggested that allergic immune diseases are...
First-in-human evaluation of a no-alpha interleukin-2 mutein: safety and preliminary pharmacodynamic and clinical effect [0.03%]
人源化临床评估无α亚基的白细胞介素-2突变体：安全性和初步药代动力学及临床效应研究
Iraida Caballero Aguirrechu,Braulio Mestre Fernández,Jorge Luis Soriano García et al.
Iraida Caballero Aguirrechu et al.
Introduction: Interleukin 2 (IL-2) is essential for immune system activation. To reduce toxicity and prevent the activation of regulatory T cells (T-regs), a novel IL-2 variant containing 4-point mutations that prevent it...
Clinical Trial
Frontiers in immunology. 2025 May 23:16:1589042. DOI:10.3389/fimmu.2025.1589042 2025
Editorial: Innate immune response and interaction with adaptive immunity: role in tuberculosis immunology/vaccinology [0.03%]
编者评论：先天性免疫反应及其与获得性免疫的相互作用在结核感染及疫苗学中的作用
Elisa M Rouse Salcido,Elena Stylianou,Styliani Karanika
Elisa M Rouse Salcido
Inge Jonkman,Maaike M E Jacobs,Yutaka Negishi et al.
Inge Jonkman et al.
Innate immune memory, also called trained immunity, is a metabolic and epigenetically regulated process that enables innate immune cells to recalibrate their inflammatory reactivity in response to pathogenic or endogenous stimuli. In additi...