Fungal immunization potentiates CD4+ T cell-independent cDC2 responses for cross-presentation [0.03%]
真菌免疫可增强CD4+T细胞独立的cDC2反应以进行交叉呈递
Nitish A Kulkarni,Som G Nanjappa
Nitish A Kulkarni
The incidence rates of fungal infections are increasing, especially in immunocompromised individuals without an FDA-approved vaccine. Accumulating evidence suggests that T cells are instrumental in providing fungal immunity. An apt stimulat...
Interacting roles of gut microbiota and T cells in the development of autoimmune hepatitis [0.03%]
肠道菌群和T细胞在自身免疫性肝炎发病中的相互作用关系
Qingwei Wu,Zhifa Ge,Chengyu Lv et al.
Qingwei Wu et al.
Autoimmune hepatitis (AIH) is a progressive liver inflammatory disease mediated by an autoimmune response, with an increasing incidence rate. In severe cases, AIH will rapidly progress to liver cirrhosis and liver failure and even lead to d...
Dual BLyS/APRIL targeted therapy with telitacicept in rituximab-refractory SLE-associated neuromyelitis optica spectrum disorder: a case report [0.03%]
利妥昔单抗难治性视神经脊髓炎谱系障碍合并系统性红斑狼疮患者使用telitacicept（双靶点BLyS/APRIL抑制剂）治疗的病例报告
Mingfen Dai,Chunyan Huang,Mingxuan Zhou et al.
Mingfen Dai et al.
This article presents a case of neuromyelitis optica spectrum disorder (NMOSD) secondary to systemic lupus erythematosus (SLE). The patient initially presented with unexplained nausea, vomiting, intractable hiccups, and significant bradycar...
Case Report: Pulmonary mixed infection by Nocardia cyriacigeorgica, Stenotrophomonas maltophilia, and human cytomegalovirus in a patient with minimal change nephrotic syndrome [0.03%]
个例报告：微小病变型肾病综合征患者肺诺卡菌、摩根不动杆菌及人巨细胞病毒混合感染病例报告
Yahua Li,Jiaqing Ye,Chenfeng Zhang et al.
Yahua Li et al.
To our knowledge, this is the first reported case of a pulmonary mixed infection involving Nocardia cyriacigeorgica, Stenotrophomonas maltophilia, and human cytomegalovirus (HCMV) in a patient with minimal change nephrotic syndrome (MCNS), ...
Studies on nanoprotein vaccine alleviating symptoms of mice allergic to rFel d 1 [0.03%]
纳米蛋白疫苗缓解rFel d 1过敏小鼠症状的研究
Yanqi Mai,Xiaozheng Sun,Xiaoxuan Liu et al.
Yanqi Mai et al.
Introduction: Globally, cat allergens are a common cause of allergic rhinitis and asthma. Fel d 1 is the primary allergen among cat allergens and can induce a broad range of allergies through airborne transmission. ...
Review of the mechanism of infection induced cerebral small vessel disease [0.03%]
感染诱导的脑小血管病发病机制的研究进展
Jiamei Song,Yiqin Wang,Zhaoxia Xie et al.
Jiamei Song et al.
Cerebral small vessel disease (CSVD) refers to a group of pathological syndromes that affect the brain's microcirculation. These conditions involve damage to small arteries, arterioles, capillaries, venules, and small veins. Cerebrovascular...
Primary Sjögren's syndrome presenting with non-diffuse membranoproliferative glomerulonephritis-like lesions in cryoglobulinemic glomerulonephritis: a case report [0.03%]
以冷球蛋白肾炎样膜增生性肾小球肾炎为首发表现的原发性舍格伦综合征1例报告
Zhi-Yu Duan,Guang-Yan Cai,FengKun Chen et al.
Zhi-Yu Duan et al.
Background: In primary membranoproliferative glomerulonephritis (MPGN), mesangial and capillary proliferation manifests as a diffuse, spherical change; in secondary MPGN, lesions are predominantly focal and segmental. ...
Post-marketing safety concerns with Tislelizumab: a disproportionality analysis of the FDA adverse event reporting system [0.03%]
替雷利珠单抗上市后安全性问题：对FDA不良事件报告系统中的信号检测分析
Chen Li,Yi Ding,Shanshan Cai et al.
Chen Li et al.
Background: Tislelizumab is an anti-programmed cell death protein 1(anti-PD-1) monoclonal antibody, which was approved by the Food and Drug Administration(FDA) on March 14, 2024. However, clinical studies are often limite...
Dendritic cell-based immunotherapy for head and neck squamous cell carcinoma: advances and challenges [0.03%]
头颈鳞癌的树突状细胞免疫治疗：进展与挑战
Wenyue Chen,Zhengqiang Li,Jin Tang et al.
Wenyue Chen et al.
Head and neck squamous cell carcinoma (HNSCC) is a prevalent cancer with poor response to conventional treatments such as surgery, chemotherapy and radiotherapy. Immune checkpoint inhibitors (ICIs) have revolutionized the treatment of HNSCC...
Host-driven evolution of PCV2: insights into genetic diversity and adaptation [0.03%]
PCV2的宿主驱动进化：关于遗传多样性和适应性的见解
Giovanni Franzo,Matteo Legnardi,Francesca Poletto et al.
Giovanni Franzo et al.
Introductions: Porcine circovirus type 2 (PCV2) is a significant pathogen in swine, exhibiting notable genetic and phenotypic diversity. This study explores the evolutionary mechanisms influencing PCV2 variability, emphas...