Serum IL-6 predicts immunotherapy-related adverse and outcome in advanced gastric and esophageal cancer patients with Anti-PD-1 treatment [0.03%]
抗PD-1治疗食管和胃腺癌患者血清IL-6预测免疫相关不良事件及疗效
Hongfang Ma,Shasha Zhang,Pengqing Jiao et al.
Hongfang Ma et al.
Purpose: Immune checkpoint inhibitors (ICIs) significantly prolong the survival of cancer patients. including gastric adenocarcinoma (GAC) and esophageal squamous cell carcinoma (ESCC) patients. Immune-related adverse eve...
IgA autoimmunity and coagulation among post-acute sequelae of SARS-CoV-2 infection (PASC) patients with persistent respiratory symptoms: a case-control study [0.03%]
SARS-CoV-2感染后急性期后综合征(PASC)患者持续呼吸道症状的IgA自身免疫和凝血状况：一项病例对照研究
Claudia Gomes,Jonathan H Whiteson,Fabio Ponzo et al.
Claudia Gomes et al.
Introduction: The SARS-CoV-2 virus resulted in significant disability and diagnostic challenges among patients with Post-Acute Sequelae of COVID-19 (PASC). Here, we assessed microvascular perfusion, clotting, and autoimmu...
The extracellular vesicle-based treatment: a developing strategy for periodontal diseases [0.03%]
基于细胞外囊泡的治疗：牙周疾病的一种潜在策略
Xuan Zhang,Hanyu Gao,Li Lin
Xuan Zhang
Periodontitis, a chronic inflammatory disease, is characterized by irreversible bone resorption, persistent attachment loss, and even ultimate tooth loss. The individual quality of life and the public burden of health are greatly impacted b...
Transcriptional regulatory logic orchestrating lymphoid and myeloid cell fate decisions [0.03%]
调控淋巴细胞和髓系细胞命运决定的转录调控逻辑
Rasoul Godini,Jingjing Yan,Michaël Chopin
Rasoul Godini
Introduction: The differentiation of hematopoietic stem cells (HSCs) into diverse blood and immune cells is a complex, highly hierarchical process characterized by a series of tightly regulated steps. It involves a sequen...
Significance of the peripheral blood Treg/Th17 ratio as a prognostic immune biomarker in newly diagnosed multiple myeloma and its correlation with 1q21 gain/amplification [0.03%]
外周血Treg/Th17比值在初治多发性骨髓瘤的预后价值及其与1q21增益/扩增相关性的研究
Jingjing Wen,Qiaolin Zhou,Fang Xu et al.
Jingjing Wen et al.
Background: Regulatory T (Treg) and T helper 17 (Th17) cells play opposing roles in immune responses, and their balance critically regulates the multiple myeloma (MM) microenvironment. Despite advances in immunotherapy, c...
A review of the efficacy of clinical tuberculosis vaccine candidates in mouse models [0.03%]
结核病临床疫苗候选株在小鼠模型中有效性的评估综述
Lidia Del Pozo-Ramos,Andreas Kupz
Lidia Del Pozo-Ramos
Tuberculosis (TB) remains one of the deadliest infectious diseases worldwide, causing over a million deaths annually. The only licensed TB vaccine for human use, Bacille Calmette-Guérin (BCG), a mycobacteria-based live-attenuated vaccine, ...
Targeting toll-like receptors: unveiling potential therapeutic strategies for deep vein thrombosis [0.03%]
靶向 Toll 样受体：深静脉血栓潜在治疗策略的研究进展
Wei Shao,Zilong Wang,Jian Wu et al.
Wei Shao et al.
Deep vein thrombosis (DVT) is a complex multifactorial vascular disease characterized by abnormal blood stasis and coagulation within the deep veins, primarily occurring in the lower limbs. This pathological condition not only causes local ...
Interpretable deep learning for gastric cancer detection: a fusion of AI architectures and explainability analysis [0.03%]
可解释的深度学习在胃癌检测中的应用：人工智能架构与可解释性分析的融合
Junjie Ma,Fang Yang,Rong Yang et al.
Junjie Ma et al.
Introduction: The rise in cases of Gastric Cancer has increased in recent times and demands accurate and timely detection to improve patients' well-being. The traditional cancer detection techniques face issues of explain...
SLC4A10 impedes atherosclerosis by diminishing IFN-γ/GZMB levels of CD8+ T cells via the MAPK pathway [0.03%]
SLC4A10通过MAPK通路抑制CD8⁺T细胞IFN-γ/GZMB水平而妨碍动脉粥样硬化形成
Bo Chen,Lei Zhu,Xueguang Lin et al.
Bo Chen et al.
Background and aims: CD8+ T cell subpopulations participate in the formation of atherosclerotic plaques through activation or exhaustion. Yet, it is unclear which specific subset it critically involved. The SLC4A10+ CD8+ ...
Roles and functions of tumor-infiltrating lymphocytes and tertiary lymphoid structures in gastric cancer progression [0.03%]
肿瘤浸润淋巴细胞和三级淋巴器官在胃癌进展中的作用及功能
Zhiyuan Yao,Gengchen Li,Di Pan et al.
Zhiyuan Yao et al.
Gastric cancer (GC), a leading cause of cancer mortality, exhibits profound molecular heterogeneity and immunosuppressive tumor microenvironment (TME) features that limit therapeutic efficacy. This review elucidates the dual roles of tertia...