Membrane-bound IL-15 co-expression powers a potent and persistent CD70-targeted TRuC T-cell therapy [0.03%]
膜结合的IL-15共表达增强CD70靶向TRuC-T细胞疗法的效力和持久性
Lindsay Webb,Michael Lofgren,Troy Patterson et al.
Lindsay Webb et al.
Introduction: Although T-cell immunotherapies have been effective in the treatment of hematological malignancies, solid tumors have proven challenging due to the immunosuppressive microenvironment and lack of viable targe...
Case Report: Multiple peripheral nerve demyelinating lesions and cerebrovascular injury which resulted in extensive cerebral infarction in a XLP1 patient without EBV infection [0.03%]
案例报告：一名未感染EB病毒的XLP1患者的多发周围神经脱髓鞘病变及脑血管损伤导致的大面积脑梗死
Jiaxun Li,Dongcan Mo,Luyu Lv et al.
Jiaxun Li et al.
X-linked lymphocytic proliferative disease type 1 (XLP1) is a primary immune deficiency caused by genetic alterations in the SH2D1A gene, exhibiting a wide variety of severe clinical phenotypes and high mortality. We present the case of a 1...
Shuaixiang Zhao,He Zhang,Guanning Shang
Shuaixiang Zhao
B7 homolog 3 (B7-H3, also known as CD276) is a novel member of the B7 immune protein family. There is a marked difference in the expression and distribution of B7-H3 protein and mRNA between normal and tumor tissues, with widespread express...
Editorial: Revolutionizing immunological disease understanding through single cell multi-omics technologies [0.03%]
editorial：通过单细胞多组学技术革新免疫性疾病的认识
Ying Zhu,Veronica G Anania,Jennie R Lill et al.
Ying Zhu et al.
Alpha-1 antitrypsin promotes re-epithelialization by regulating inflammation and migration [0.03%]
α-1抗胰蛋白酶通过调节炎症和迁移促进上皮重塑
Idan Farber,Muhammad Wated,Ronen Schuster et al.
Idan Farber et al.
Purpose: Regulation of inflammation and re-epithelialization are critical for efficient wound healing. This study explores the role of human α1-antitrypsin (hAAT), an immunomodulatory protein, in modulating inflammation ...
Markers of T cell activation and exhaustion in plasma are associated with persistent symptoms up to 18 months following mild SARS-CoV-2 infection [0.03%]
T细胞激活和衰竭的标志物与轻度新冠病毒感染后长达18个月的持续症状有关
Thor Ueland,Rebecca Jane Cox,Annika E Michelsen et al.
Thor Ueland et al.
Background: Persistent symptoms following SARS-CoV-2 is an increasing problem after COVID-19 disease. The pathogenesis of this persistent post Covid-19 Condition (PCC) is, however, largely unknown. We hypothesized that pe...
Cord blood-derived iNK T cells as a platform for allogeneic CAR T cell therapy [0.03%]
基于脐带血诱导的自然杀伤性T细胞的同种异体CAR-T平台疗法
Maison Grefe,Abel Trujillo-Ocampo,Jelita Clinton et al.
Maison Grefe et al.
CD1d-restricted invariant Natural Killer (iNK) T cells are a suitable candidate for allogeneic Chimeric Antigen Receptor (CAR) T cell therapy as they do not cause graft-versus-host disease (GvHD) due to the monomorphic nature of CD1d protei...
Proteome-wide characterization of PTMs reveals host cell responses to viral infection and identifies putative antiviral drug targets [0.03%]
泛磷酸化蛋白质组揭示了细胞对病毒感染的响应并鉴定出潜在的抗病毒药物靶标
Xiaolu Li,Adam Kabza,Ashley N Ives et al.
Xiaolu Li et al.
Post-translational modifications (PTMs) are biochemical modifications that can significantly alter protein structure, function, stability, localization, and interactions with other molecules, thereby activating or inactivating intracellular...
Evolutionary insights into Interleukin-12 family targets across 405 species [0.03%]
405种物种白细胞介素-12家族靶基因的进化见解
Weibin Wang,Dawei Li,Kaiyong Luo et al.
Weibin Wang et al.
The Interleukin-12 (IL-12) family ligand subunits (IL-12s) and receptor subunits (IL-12Rs) constitute pivotal regulators of immune homeostasis, with direct implications in autoimmune pathologies and oncogenesis. Through phylogenetic reconst...
Splenic volume as a predictor of survival in cancer patients treated with immune checkpoint inhibitors [0.03%]
脾体积作为免疫检查点抑制剂治疗癌症患者生存预测指标的研究
Yunhua Zhang,Xin Fu,Lilong Zhang et al.
Yunhua Zhang et al.
Objective: This investigation seeks to examine the association between spleen volume and prognosis in cancer patients undergoing immune checkpoint inhibitor (ICI) treatment. ...