Phosphatidylcholine-specific B cells are enriched among atypical CD11chigh and CD21low memory B cells in antiphospholipid syndrome [0.03%]
抗磷脂综合征中存在富含自身反应性B细胞的非典型记忆B细胞群簇
Eduard Nitschke,Van Duc Dang,Hector Rincon-Arevalo et al.
Eduard Nitschke et al.
Background: Patients with antiphospholipid syndrome (APS) carry an increased risk of thrombosis and adverse pregnancy outcomes due to the presence of antiphospholipid autoantibodies (aPL). However, the pathogenesis of the...
Case Report: Coexistence of anti-LGI1 and anti-mGluR2 antibodies in an autoimmune encephalitis patient [0.03%]
自身免疫性脑炎患者中LGI1和mGluR2抗体并存的病例报告
Xudong Zhang,Fei Ma,Qingqing Geng et al.
Xudong Zhang et al.
Autoimmune encephalitis (AE) encompasses a broad group of inflammatory encephalopathies mediated by immune responses against central nervous system (CNS) antigens. With the expanding spectrum of identified anti-neuronal antibodies and their...
Transcriptional profiling reveals H.pylori-associated genes induced inflammatory cell infiltration and chemoresistance in gastric cancer [0.03%]
转录谱分析揭示Hp感染相关基因通过促炎细胞浸润和化学抗性诱导胃癌发生
Jinshui Tan,Zhengxin Wu,Yuankun Liu et al.
Jinshui Tan et al.
Background: H. pylori infection is closely associated with the tumor microenvironment (TME) in gastric cancer (GC), yet its underlying mechanism is elusive. Hence, it is imperative to explore the microenvironment and drug...
The influence of high-fat diet and energy-restricted diet on hematopoietic stem cells: mechanisms and implications [0.03%]
高脂饮食和限能饮食对造血干细胞的影响：机制及意义
Zhi&#x;an Chen,Haoyuan Ang,Jie Li et al.
Zhi&#x;an Chen et al.
Increasing evidence demonstrates a close relationship between daily diet and homeostasis of the body's internal environment, particularly hematopoietic system homeostasis. Hematopoietic stem cells (HSCs) are located at the top of the hemato...
Decoding the molecular landscape: HER2 and PD-L1 in advanced gastric cancer [0.03%]
解码分子图谱：晚期胃癌中的HER2和PD-L1
Jun Yao,Qiang Sun,Han Wu et al.
Jun Yao et al.
Introduction: Epidermal growth factor receptor 2 (HER2) and programmed cell death ligand 1 (PD-L1) are pivotal therapeutic targets for advanced gastric cancer (GC). Nevertheless, the correlation between them, along with t...
Pan-cancer analysis of TMED2: unraveling potential immune characteristics and prognostic value in cancer therapy [0.03%]
TMED2的泛癌症分析：揭示其在癌症治疗中的潜在免疫特征和预后价值
Zhuangzhi Wang,Changning Sun,Pengfei Wang et al.
Zhuangzhi Wang et al.
Background: Transmembrane emp24 domain-containing protein 2 (TMED2) is involved in the sorting and transport of proteins between the Golgi apparatus and the endoplasmic reticulum. Recent research has identified a close as...
Single-cell transcriptome profiling reveals dynamic cell populations and immune infiltration in cerebral cavernous malformation [0.03%]
单细胞转录组分析揭示了脑海绵状血管畸形的动态细胞群和免疫浸润
Zhiguang Han,Chengxu Lei,Zhenyu Zhou et al.
Zhiguang Han et al.
Introduction: The cellular subpopulations and signaling pathways in the pathological tissues of cerebral cavernous malformation (CCM) remain incompletely understood. To gain a deeper understanding of the pathogenesis of C...
Immunogenomic characteristics and prognostic implications of terminally exhausted CD8+ T cells in colorectal cancers [0.03%]
结直肠癌中终末耗竭CD8+T细胞的免疫组学特征及其预后意义
Ji-Ae Lee,Hye Eun Park,Dae-Won Lee et al.
Ji-Ae Lee et al.
Introduction: T-cell exhaustion is a major mechanism of immune evasion. Recently, the therapeutic and prognostic implications of progenitor exhausted T cells (Tpex) and terminally exhausted T cells (Ttex) have been explor...
KDDC: a new framework that integrates kmers, dataset filtering, dimension reduction and classification algorithms to achieve immune cell heterogeneity classification [0.03%]
一种新的免疫细胞异质性分类框架KDDC
Nan Zhang,Shishun Zhao,Runze Wu et al.
Nan Zhang et al.
Introduction: Integrating immune repertoire sequencing data with single cell sequencing data offers profound insights into the diversity of immune cells and their dynamic changes across various disease states. ...
Interferon-β and interleukin-6 exert opposing effects on Foxp3 acetylation to control regulatory T cell induction [0.03%]
干扰素-β和白细胞介素-6通过相反的作用调节Foxp3乙酰化来控制诱导性调节T细胞的产生
Mehek Ningoo,Francisco Fueyo-González,Cayetana Gisbert-Vilanova et al.
Mehek Ningoo et al.
Cytokines are key soluble signaling molecules that regulate immune responses. With the advent of therapies that selectively target cytokines and cytokine receptors, understanding the molecular mechanisms underpinning how immune cells integr...