Role of interleukin-16 in human diseases: a novel potential therapeutic target [0.03%]
细胞因子IL-16在人类疾病中的作用——一种潜在的治疗靶点
Timothy B Niewold,Julia S Lehman,Iva Gunnarsson et al.
Timothy B Niewold et al.
Interleukin (IL)-16 is expressed mostly by the cells of the human immune system. Upon cell activation IL-16 is cleaved, forming two functional proteins, one regulating cell cycle and the other acting as chemoattractant for the cells carryin...
Editorial: Community series in emerging insights in controlling autoimmunity, volume II [0.03%]
论点：新兴的自身免疫控制见解系列社区第2卷
Lorenza Bruno,Dimitrios Bogdanos,Maria Maslinska et al.
Lorenza Bruno et al.
IFN-γ gene polymorphisms +874 T/A and +2109 A/G are associated with the serofast state after early syphilis treatment: a prospective observational study [0.03%]
干扰素γ基因多态性+874T/A和+2109A/G与早期梅毒治疗后血清固定状态相关：一项前瞻性观察研究
Konrad Kaminiów,Martyna Kiołbasa,Maciej Pastuszczak
Konrad Kaminiów
Background: In approximately 20% of patients with early syphilis, the classical serological response pattern is absent following treatment. They experience a serofast state, which manifests as less than a 4-fold decline i...
Observational Study
Frontiers in immunology. 2025 Jun 2:16:1602527. DOI:10.3389/fimmu.2025.1602527 2025
Unravelling the link between chronic inflammation and primary hyperparathyroidism: a systematic review [0.03%]
慢性炎症与原发性甲状旁腺功能亢进症之间联系的系统评价
Ana Gheorghe-Milea,Oana Stănoiu-Pînzariu,Carmen Emanuela Georgescu
Ana Gheorghe-Milea
Introduction: Primary hyperparathyroidism (PHPT) is a multisystemic endocrine disorder characterized by an incompletely understood pathogenesis, a complex clinical picture and various complications. Chronic inflammation r...
Resistance training alleviates muscle atrophy and muscle dysfunction by reducing inflammation and regulating compromised autophagy in aged skeletal muscle [0.03%]
阻力训练通过减轻炎症和调节自噬在老年骨骼肌中的作用从而缓解肌肉萎缩和功能障碍
Yangfan Cao,Jiawei Zhou,Helong Quan et al.
Yangfan Cao et al.
Background: Age related muscle atrophy is associated with chronic inflammation and impaired autophagy. Resistance training serves as an effective intervention for enhancing skeletal muscle hypertrophy. ...
Autophagy in aquatic animals: mechanisms, implications, and future directions [0.03%]
水生动物的自噬作用：机制、意义及未来方向
Md Abu Kawsar,Diponkor Adikari,Yang Zhang
Md Abu Kawsar
Autophagy, a highly conserved intracellular degradation process, is essential for maintaining cellular homeostasis, supporting development, modulating immune responses, and enhancing stress adaptation in eukaryotic organisms. In aquatic ani...
Case Report: Unilateral relapsing primary central nervous system vasculitis-expanding the phenotype [0.03%]
个例报告：单侧复发性中枢神经系统血管炎——扩展临床表现形式
Turlough Montague,Jenny Han,Emily Cheung et al.
Turlough Montague et al.
Background: Unilateral relapsing primary central nervous system vasculitis (UR-PCNSV) is a scarcely reported subtype of PCNSV. It is characterised by frequent relapses with lesions confined to a single hemisphere. Herein,...
Fbxo16 mediates degradation of NF-κB p65 subunit and inhibits inflammatory response in dendritic cells [0.03%]
FBXO16通过降解NF-κB P65亚基抑制树突状细胞中的炎症反应
Akiko Sugimoto-Ishige,Aya Jodo,Takashi Tanaka
Akiko Sugimoto-Ishige
Activation of transcription factor NF-κB is tightly regulated by negative regulatory systems that prevent excessive inflammation leading to autoimmune diseases. We previously demonstrated that PDLIM2, a PDZ-LIM domain-containing nuclear pr...
Immunomodulatory effects of gut microbiota on vaccine efficacy against respiratory pathogens [0.03%]
肠道微生物对呼吸道病原体疫苗效力的免疫调节作用
Li Xue,Chunhua Wang,Chuanyu Liu
Li Xue
The outbreaks of respiratory pathogens like severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and influenza virus (IV) have heightened the demand for highly effective vaccines that provide strong and durable immunity in human pop...
Preliminary research indicates that mechanical force through Pioze1 enhances local immunity during NPWT treatment for spinal infections [0.03%]
初步研究显示，在应用负压伤口治疗装置防治脊椎感染时，Pioze1可增强局部免疫力
Hao Xing,Junlin Pan,Huan Liu et al.
Hao Xing et al.
Objective: This study aims to investigate the mechanism by which Negative Pressure Wound Therapy (NPWT) regulates local immune responses in spinal infection through Piezo1-mediated mechanical stress, and elucidate its pot...