Correlation between increased total serum IgE levels and clinical features in alopecia areata patients [0.03%]
血清总IgE水平升高与斑秃临床特征的相关性研究
Yijie Sun,Shuang Xu,Yujing Zhang et al.
Yijie Sun et al.
Backgrounds: Alopecia areata (AA) is primarily associated with a Type 1 (Th1) inflammatory response, but emerging evidence also suggests a potential contribution of Type 2 (Th2) immunity. However, the relationship between...
Dual variants of uncertain significance in a case of hyper-IgM syndrome: implications for diagnosis and management [0.03%]
高IgM综合征的双重意义未明变异对诊断和治疗的意义
Nourhen Agrebi,Rafah Mackeh,Mohamed Alsabbagh et al.
Nourhen Agrebi et al.
Background: Hyper-IgM syndrome (HIGM) is a genetic immunodeficiency characterized by elevated to normal IgM levels and decreased IgG, IgA, and IgE. The overlapping clinical presentations of different gene mutations compli...
Inactivated Rothia nasimurium promotes a persistent antiviral immune status in porcine alveolar macrophages [0.03%]
鼻炎莫拉库瓦菌灭活疫苗促进猪肺泡巨噬细胞的持续抗病毒免疫状态
Aida Tort-Miró,Uxía Alonso,Beatriz Martín-Mur et al.
Aida Tort-Miró et al.
Globalization has increased the incidence of infectious diseases in livestock, further aggravated by the reduction of antibiotic usage. To minimize the resulting economic consequences to the meat production industry, as well as the risk of ...
Immunological pathogenesis of inflammatory bowel disease: focus on tissue resident memory T cells [0.03%]
炎症性肠病的免疫病理学：关注组织驻留记忆T细胞
Jiayan Hu,Wenting Wang,Muyuan Wang et al.
Jiayan Hu et al.
Tissue-resident memory T (TRM) cells are a type of tissue-restricted memory T cells with terminal differentiation and a memory function. They exist in mucosal tissues for a long period. In the absence of disease, TRM cells promote essential...
STAT3 inhibition in combination with CD47 blockade inhibits osteosarcoma lung metastasis [0.03%]
STAT3抑制联合CD47阻滞可抑制骨肉瘤肺转移
Pradeep Shrestha,Rejeena Shrestha,You Zhou et al.
Pradeep Shrestha et al.
Background: New therapies are urgently needed for patients with osteosarcoma (OS). STAT3 and CD47 are potential therapeutic target in OS. Here we investigated the therapeutic activity of the orally bioavailable STAT3 inhi...
Lymphatic dissemination of HPV-positive oropharyngeal squamous cell carcinoma: underlying mechanisms and treatment innovations [0.03%]
人乳头瘤病毒阳性的咽部鳞状细胞癌的淋巴扩散：潜在机制和治疗创新举措
Xinyu Li,Hui Qiu,Qiuji Wu
Xinyu Li
Cancers, with its rising incidence strongly linked to human papillomavirus (HPV) infection, particularly HPV16. HPV-induced OPSCC (HPV-OPSCC) exhibits distinct biological behaviors, including a high propensity for early lymphatic metastasis...
Unveiling the role of NAD glycohydrolase CD38 in aging and age-related diseases: insights from bibliometric analysis and comprehensive review [0.03%]
基于文献计量分析和综述的NAD糖基水解酶CD38在衰老及相关疾病中的作用机制及其应用前景
Xianghui Zhao,Peiying Lv,Zixing Cai et al.
Xianghui Zhao et al.
Background: CD38, a glycoprotein with a single transmembrane structure, is extensively found in erythrocytes, immune cells, and endothelial cells. Primarily located on cell membranes, it plays a critical role in metaboliz...
The role of major allergens Art v 1 and Art v 3 in Artemisia pollen-induced asthma: a mouse model study [0.03%]
欧洲蒿花粉致敏蛋白Art v 1和Art v 3在哮喘小鼠模型中的作用研究
Nazugum Akhtemova,Akbota Sergazina,Turlan Bolatbekov et al.
Nazugum Akhtemova et al.
Background: Artemisia pollen is a major airborne allergen contributing to seasonal allergic rhinitis and bronchial asthma worldwide. However, the specific allergenic potential of different Artemisia species and their majo...
Conversion study of hepatocellular carcinoma using HAIC combined with lenvatinib and PD-1/L1 immunotherapy under the guidance of BCLC staging [0.03%]
基于巴塞罗那肝癌分期指导的HAIC联合仑伐替尼和PD-1/L1免疫治疗转化研究HBV相关晚期 hepatocellular carcinoma 的临床疗效及安全性分析
Weihao Zhang,Xiaohui Zhao,Wei Gao et al.
Weihao Zhang et al.
Objective: This study aimed to assess the efficacy and safety of hepatic arterial infusion chemotherapy (HAIC) combined with lenvatinib and immunotherapy and explore its potential as a conversion treatment for unresectabl...
High-fat diet-induced adipose tissue-resident macrophages, T cells, and dendritic cells modulate chronic inflammation and adipogenesis during obesity [0.03%]
高脂饮食诱导的肥胖期间脂肪组织驻留巨噬细胞、T淋巴细胞和树突状细胞在慢性炎症和脂肪生成中的作用
Mousumi Mandal,Md Abdullah Al Mamun,Ahmed Rakib et al.
Mousumi Mandal et al.
Background: Obesity is one of the major healthcare challenges and socio-economic liabilities worldwide and is rapidly reaching pandemic proportions. Characterized by low-grade chronic inflammation in adipose tissue (AT), ...