T cell-mediated immune surveillance conferred by latent Epstein-Barr virus genes suppresses a broad spectrum of tumor formation through NKG2D-NKG2DL interactions [0.03%]
潜伏的EB病毒基因通过NKG2D-NKG2DL相互作用介导T细胞免疫监视，抑制多种肿瘤形成
Yuqi Jin,Yun Guo,Yohei Kawano et al.
Yuqi Jin et al.
Epstein-Barr virus (EBV)-infected B cells effectively induce T cell-mediated immune surveillance that suppresses the proliferation of EBV+ B cells and development of lymphomas. However, it remains unclear whether EBV-specific T cells are in...
IL-17A-producing γδ T cells and classical monocytes are associated with a rapid alloimmune response following vascularized composite allotransplantation in mice [0.03%]
小鼠血管化复合组织移植后产生IL-17A的γδT细胞和经典单核细胞与快速移植物抗宿主反应相关
Tetsuya Tajima,Wenming Zhang,Shuling Han et al.
Tetsuya Tajima et al.
Background: Vascularized Composite Allotransplantation (VCA) is an important therapeutic option for patients that incur debilitating injuries to the face or limbs. The complexity and immunogenicity of tissue types within ...
Interplay of hypoxia, immune dysregulation, and metabolic stress in pathophysiology of type 1 diabetes [0.03%]
缺氧、免疫紊乱和代谢压力在1型糖尿病病理生理学中的相互作用
Rahul Mittal,Joana R N Lemos,Prem Chapagain et al.
Rahul Mittal et al.
Type 1 diabetes (T1D) is an autoimmune disease characterized by the progressive destruction of pancreatic β-cells, leading to insulin deficiency and chronic hyperglycemia. While immune-mediated mechanisms of β-cell destruction are well-re...
Cancer-associated fibroblasts in clear cell renal cell carcinoma: functional heterogeneity, tumor microenvironment crosstalk, and therapeutic opportunities [0.03%]
透明细胞肾细胞癌相关成纤维细胞：功能异质性、肿瘤微环境相互作用及治疗机会
Man Wang,Yuanzhuo Zhao,Kangchun Xu et al.
Man Wang et al.
Clear cell renal cell carcinoma (ccRCC) progression heavily relies on the immunosuppressive tumor microenvironment (TME). In the ccRCC TME, the cancer-associated fibroblasts (CAFs) drive a self-perpetuating cycle of immune evasion and thera...
Serum extracellular vesicle microRNAs as potential biomarkers to predict pembrolizumab response and prognosis in metastatic non-small cell lung cancer patients [0.03%]
外泌体mirna作为潜在生物标志物预测肺转移性非小细胞肺癌患者对pembrolizumab的反应和预后
Daniela Lamorte,Luciana De Luca,Alfredo Tartarone et al.
Daniela Lamorte et al.
Introduction: Circulating Extracellular Vesicles (cEVs) could represent new non-invasive biomarkers for diagnosis and prognosis in tumors. In the context of Non-Small Cell Lung Cancer (NSCLC) immunotherapy there's a great...
Tertiary lymphoid structures in esophageal cancer: a novel target for immunotherapy [0.03%]
食管癌中的三级淋巴器官：免疫治疗的新靶点
Ke Zhai,Yuting Ma,Xue Gao et al.
Ke Zhai et al.
Esophageal cancer (EC), especially esophageal squamous cell carcinoma (ESCC), which is the most common subtype in China, is one of the most aggressive gastrointestinal malignancies. Traditional treatments like surgery, radiotherapy, and che...
Jessica M Salmon,Holly Adams,Graham W Magor et al.
Jessica M Salmon et al.
The Krüppel-like factor (KLF) family of zinc finger transcription factors regulate the expression of genes involved in a wide range of cellular processes, including cell proliferation and differentiation. In haematopoiesis, KLFs have essen...
Osteosarcoma immune microenvironment: cellular struggle and novel therapeutic insights [0.03%]
骨肉瘤免疫微环境：细胞互作和新的治疗思路
Yi Zhang,Shasha Jiang,Jing Lv et al.
Yi Zhang et al.
Recent advances in immunotherapy have shown remarkable success across multiple solid tumor types, revitalizing interest in immune-modulating strategies for osteosarcoma (OS). Within the complex tumor microenvironment (TME), immune cells exh...
Immune metabolic restoration in systemic lupus erythematosus: the impact of gut microbiota, probiotics, and nutritional synergy [0.03%]
系统性红斑狼疮中的免疫代谢恢复：肠道微生物群、益生菌和营养协同作用的影响
Douae Nihed Habiballah,Fanzhu Li,Lai Jiang
Douae Nihed Habiballah
Gut microbiota alterations have been considered one of the attributes of Systemic Lupus Erythematosus (SLE), and may offer an immunological disorder and even cause the disease. The probiotic administration, especially the Lactobacillus and ...
Adverse drug reactions related to methotrexate: a real-world pharmacovigilance study using the FAERS database from 2004 to 2024 [0.03%]
2004-2024年间利用FAERS数据库开展的甲氨蝶呤相关药品不良事件真实世界研究
Siyu Liu,Zhang Yuan,Shicong Rao et al.
Siyu Liu et al.
Objective: To comprehensively analyze the safety profile of Methotrexate in clinical use, clarify the incidence of adverse reactions and associated influencing factors, and provide evidence for safe medication practices i...