F-box proteins at the crossroads of ubiquitination and tumor immunity: regulatory networks and immunotherapy strategies [0.03%]
处于泛素化和肿瘤免疫交叉点的F-BOX蛋白：调控网络与免疫治疗策略
Mingzheng Dai,Shimin Chen,Yuanjing Wang et al.
Mingzheng Dai et al.
As critical substrate-recognition subunits of the SCF (SKP1-CUL1-F-box) ubiquitin ligase complex, F-box proteins mediate the ubiquitination and subsequent degradation of specific target proteins, playing pivotal roles in cell cycle regulati...
Tumor marker pseudoprogression and immune-related cholangitis during conversion therapy for massive hepatocellular carcinoma: a case report [0.03%]
巨大肝细胞癌经转化治疗后肿瘤标志物假性进展及免疫相关胆管炎一例报告
Xiaodong Zhang,Luyi Zhang,Shuangying Zhao et al.
Xiaodong Zhang et al.
Cases with massive (diameter ≥10 cm) hepatocellular carcinomas (HCCs) are uncommon and typically have poor outcomes; however, conversion therapy offers a beacon of hope for remission in patients with massive unresectable HCCs. Recently, im...
Computational design and evaluation of multiepitope vaccines against herpes simplex virus type 1 [0.03%]
用于对抗Ⅰ型单纯胞疹病毒的多抗原表位疫苗的计算设计和评估
Zibo Zhao,Weixiong Wang,Jiaping Pang et al.
Zibo Zhao et al.
Introduction: Herpes simplex virus type 1 (HSV-1) is a prevalent human pathogen, causing infections in various tissues and leading to severe complications such as herpes simplex encephalitis and cognitive impairments. Des...
Novel NUDCD1 gene variant predisposes to severe COVID-19 disease in Asians through modulation of antiviral DHX15- and MAVS-mediated signalling [0.03%]
新基因变异通过调节抗病毒DHX15和MAVS介导信号使亚洲人易患严重新冠肺炎疾病
Aseervatham Anusha Amali,Douglas Jie Wen Tay,Yiqi Seow et al.
Aseervatham Anusha Amali et al.
Background: Genome-wide associative studies can potentially uncover novel pathways which modulate anti-viral immune responses against SARS-CoV-2 or identify drivers of severe disease. To date, these studies have yielded l...
Role of CD28+ PD-1+ Tc cells in immune response and prognosis prediction in hepatocellular carcinoma [0.03%]
CD28+PD-1+Tc细胞在肝癌免疫应答及预后评估中的作用
Wuhan Yang,Teng Pan,Yaowen Chen et al.
Wuhan Yang et al.
Background: CD28+PD-1+ Tc cells (CD8+ T cells) constitute a dysfunctional subset of T cell; however, the mechanisms underlying their dysfunction and their significance in hepatocellular carcinoma (HCC) remain unclear. We ...
Impact of NF-κB and reactive oxygen species on intracellular BAFF/APRIL expression in ANCA-associated vasculitis: focusing on the effect of resveratrol [0.03%]
NF-κB和活性氧对ANCA相关性血管炎细胞内BAFF/APRIL表达的影响及白藜芦醇的干预作用研究
Yasuhiro Shimojima,Dai Kishida,Takanori Ichikawa et al.
Yasuhiro Shimojima et al.
Increased expression of B-cell activation factor of the tumor necrosis factor family (BAFF) and a proliferation-inducing ligand (APRIL) expression, which have been observed not only in the active phase of antineutrophil cytoplasmic antibody...
Janus kinase and signal transducer and activator of transcription inhibitors in type 1 diabetes and immune checkpoint-related diabetes: current status and future perspectives [0.03%]
janus激酶和信号转导子及转录激活剂抑制剂在1型糖尿病及相关免疫检查点糖尿病中的研究现状与未来前景
Bowei Su,Zhi-Lin Luan,Haixia Liu et al.
Bowei Su et al.
Type 1 diabetes (T1D) is an autoimmune-mediated disorder that leads to the destruction of pancreatic beta-cells, insulin deficiency, and chronic hyperglycemia. It is one of the most common childhood endocrine disorders. Recent evidence indi...
Exosomal let-7b-5p derived from Aspergillus fumigatus-treated human corneal epithelial cells promotes M1 macrophage activation via targeting SOCS-1 [0.03%]
烟曲霉感染的人角膜上皮细胞来源的外泌体let-7b-5p通过靶向SOCS-1促进M1型巨噬活化
Xiaoming Yu,Xinyi Wu
Xiaoming Yu
Purpose: This study aimed to explore the impact of exosomal miRNAs derived from Aspergillus fumigatus (A. fumigatus)-treated human corneal epithelial cells (HCECs) on M1 macrophage activation. We further clarified the mec...
Integrated machine learning and single-cell analysis reveal the prognostic and therapeutic potential of SUMOylation-related genes in ovarian cancer [0.03%]
整合机器学习和单细胞分析揭示卵巣癌中SUMO化相关基因的预后和治疗潜力
Zhengrong Deng,Yicong Xu,Peidong Zhang et al.
Zhengrong Deng et al.
Introduction: Ovarian cancer (OC) exhibits high mortality and chemoresistance rates, underscoring the urgent need for precise prognostic biomarkers and novel therapeutic targets. SUMOylation, crucial in cellular stress re...
Clinical and electrophysiological features of adult patients with combined central and peripheral demyelination- a systematic review [0.03%]
中枢和周围脱髓鞘病成人患者临床及电生理特点的系统综述
Szymon Andrusiów,Edyta Dziadkowiak,Magdalena Koszewicz
Szymon Andrusiów
Background: The classification of combined central and peripheral demyelination (CCPD) is challenging due to unclear pathomechanisms and a lack of diagnostic and therapeutic criteria. Existing clinical data are limited to...