Pro-dermcidin and derivatives as potential therapeutics for lethal experimental sepsis [0.03%]
促dermcidin及其衍生物作为致命性实验性脓毒症的潜在治疗药物
Weiqiang Chen,Xiaoling Qiang,Cassie Shu Zhu et al.
Weiqiang Chen et al.
A 110-amino acid precursor of dermcidin (pre-dermcidin, pre-DCD) with a 19-residue N-terminal leader signal sequence can be secreted by human eccrine sweat glands as a leader-less pro-domain-containing peptide (pro-DCD), which is enzymatica...
Impact of a moderate-intensity aerobic exercise intervention on systemic and uterine natural killer cells in women with unexplained recurrent pregnancy loss [0.03%]
中等强度有氧运动干预对不明原因复发性流产女性全身及子宫自然杀伤细胞的影响研究
Aysel Gurbanova,Amber E M Lombardi,Denise H J Habets et al.
Aysel Gurbanova et al.
Introduction: Recurrent pregnancy loss (RPL) is associated with altered immune phenotypes and functions. It has been proposed that physical exercise might impact the immune system. Therefore, we evaluated the effect of a ...
Clinical Trial
Frontiers in immunology. 2025 Jun 4:16:1602939. DOI:10.3389/fimmu.2025.1602939 2025
Elucidation of B-cell specific drug immunogenicity liabilities via a novel ex vivo assay [0.03%]
通过新型体内检测法阐明B细胞特异性药物免疫原性缺陷
Cary M Looney,Axel Ducret,Guido Steiner et al.
Cary M Looney et al.
The advent of large molecule therapeutics has revolutionized treatment options for previously unmet medical needs. This advent has also led to an increased impact of immunogenicity on drug efficacy and safety. In order to maximize the poten...
Nanomaterials and immune checkpoint inhibitors in cancer immunotherapy: the synergistic innovation prospects [0.03%]
纳米材料和免疫检查点抑制剂在癌症免疫治疗中的协同创新前景
Jing Chen,Xue Cheng
Jing Chen
Tumor cells can utilize the immune checkpoint pathway to inhibit T cell activation and evade the attack of tumor specific T cells. While immune checkpoint inhibitors (ICIs) competitively bind to checkpoint molecules to block checkpoint medi...
Immune-mediated renal injury in diabetic kidney disease: from mechanisms to therapy [0.03%]
糖尿病肾脏病的免疫介导肾损伤：从机制到治疗
Lingli Ma,Dianyuan Liu,Yue Yu et al.
Lingli Ma et al.
Diabetic kidney disease (DKD) is now recognized as a multifactorial disorder, driven by the interplay of metabolic dysfunction, chronic inflammation, and immune-mediated renal injury. This review comprehensively synthesizes recent advanceme...
Cytokine secretion patterns distinguish herpes simplex virus type 2 meningitis from herpes simplex virus type 2 genital herpes [0.03%]
细胞因子分泌模式可区分单纯疱疹病毒2型脑膜炎和生殖器疱疹
Moa Bjerhem,Alexandra Svensson,Marie Studahl et al.
Moa Bjerhem et al.
The aim of this study was to identify immune factors that distinguish patients with herpes simplex virus type 2 (HSV-2) meningitis from patients with HSV-2 genital herpes by analyzing demographic data, in vitro production of cytokines and o...
Exosomes in hypoxia: generation, secretion, and physiological roles in cancer progression [0.03%]
缺氧条件下的外泌体：生成、分泌及在癌症进展中的生理作用
Yufeng Mu,Mengrui Yang,Jingyang Liu et al.
Yufeng Mu et al.
The hypoxic microenvironment represents a universal hallmark feature of most solid tumors, profoundly shaping cancer progression through multifaceted mechanisms. Acting as nanoscale molecular envoys, exosomes transport oncogenic cargoes (in...
The relationship between polycystic ovary syndrome and gynecological cancers: neurotransmitter metabolism changes and immune regulation [0.03%]
多囊卵巢综合征与妇科肿瘤的关系：神经递质代谢改变和免疫调节作用
Dongning Wu,Yue Zhang,Congying Wu et al.
Dongning Wu et al.
Polycystic ovary syndrome (PCOS) is a common endocrine disorder affecting approximately 10% of middle-aged women worldwide. It is characterized by hirsutism, anovulation, and polycystic ovaries. Various factors, including environmental toxi...
Mechanism of cell death and its application in the repair of inflammatory bowel disease by mesenchymal stem cells [0.03%]
间充质干细胞修复炎症性肠病的细胞死亡机制及其作用应用研究
Francis Atim Akanyibah,Chang&#x;e He,Peipei Cai et al.
Francis Atim Akanyibah et al.
The onset and progression of inflammatory bowel disease (IBD), which encompasses ulcerative colitis and Crohn's disease, are influenced by the immune system, environmental factors, genetics, and intestinal flora. Cell death is a biological ...
Aging induces T cells with distinct transcriptomic profiles and functions in brain-associated tissues [0.03%]
衰老诱导大脑相关组织中具有不同转录组特征和功能的T细胞
Youwen Si,Yuanyue Zhang,Qi Yang
Youwen Si
Background: Aging is known to induce the emergence of distinct lymphocyte populations with unique molecular and functional characteristics. However, the impact of aging on the transcriptomes and functional activities of C...