An RNA vaccine against adrenomedullin reduces angiogenesis and tumor burden in a syngeneic metastatic melanoma mouse model [0.03%]
一种针对肾上腺素中素的RNA疫苗通过减少血管生成和肿瘤负荷来抑制同基因黑色素瘤小鼠模型中的转移
Srdan Tadic,Laura Ochoa-Callejero,Judit Narro-Íñiguez et al.
Srdan Tadic et al.
Introduction: Adrenomedullin (AM) is an autocrine/paracrine growth factor as well as a crucial regulator of angiogenesis and immune response. AM is overexpressed by most solid tumors, which makes it a good target for anti...
Reduced hemolytic complement activity in the classical pathway (CH50) is a risk factor for poor clinical outcomes of patients with infections: a retrospective analysis of health insurance claims in Japan [0.03%]
补体经典途径(CH50)活性降低是感染患者不良临床结局的风险因素：日本健康保险理赔数据的回顾性分析
Hiroyuki Koami,Yutaro Furukawa,Yuri Hirota et al.
Hiroyuki Koami et al.
Purpose: To evaluate whether low CH50 (a comprehensive measure of hemolytic activity of the classical complement pathway) is associated with infection-related coagulopathy, organ dysfunction, and poor clinical outcomes. ...
In silico multi-epitope-based vaccine design for Mycobacterium avium complex species [0.03%]
结核分枝杆菌复合群病原蛋白的多表位疫苗设计仿真研究
Leah Kashiri,Wonderful T Choga,Tinashe Musasa et al.
Leah Kashiri et al.
Introduction: The Mycobacterium avium complex (MAC)-comprising M. colombiense, M. avium, andM. intracellulare-is an emerging group of opportunistic pathogens responsible for significant morbidity and mortality, particular...
Unveiling regulatory variants in the blood transcriptome and their association with immunity traits in pigs [0.03%]
猪血液转录组中的调控变异及其与免疫性状的关联解析
Teodor Jové-Juncà,Daniel Crespo-Piazuelo,Carles Hernández-Banqué et al.
Teodor Jové-Juncà et al.
Genome wide association studies (GWAS) have been widely used to investigate the association of genetic markers with complex traits in both humans and livestock species. A particular trait of interest, when studying animal robustness and gen...
Inhibition of human gastric cancer growth by cytokine-induced killer cells plus chemotherapy with or without cadonilimab in a mouse xenograft tumor model [0.03%]
细胞因子诱导的杀伤细胞联合化疗及/或卡度尼利单抗抑制人类胃癌增长的小鼠异种移植瘤模型研究
Wenwei Yang,Jingwei Liu,Tiantian Hou et al.
Wenwei Yang et al.
Background: Cytokine-induced killer (CIK) cell therapy has shown potent antitumor cytotoxicity. To date, no study has evaluated the efficacy and safety of combining CIK cell therapy with chemotherapy, with or without the ...
Machine learning for predicting distant metastasis in nasopharyngeal carcinoma patients [0.03%]
机器学习在鼻咽癌患者远处转移预测中的研究
Hong Sun,Jijie Zhu,Ling Li et al.
Hong Sun et al.
Background: Distant metastasis is the main cause of treatment failure and death in patients with nasopharyngeal carcinoma (NPC). The aim of this study was to explore the risk factors for distant metastasis in NPC patients...
Identification of the microglia-associated signature in experimental autoimmune encephalomyelitis [0.03%]
实验性自身免疫性脑脊髓炎中与小胶质细胞相关的特征识别
Yan Wu,Jianhong Wang,Bo Chen et al.
Yan Wu et al.
Background: Multiple sclerosis (MS) is a chronic neuroinflammatory disorder characterized by demyelination and immune dysregulation, and microglia play a central role in disease progression. Despite this, the specific mic...
Association of dietary quality and dietary inflammatory potential with inflammatory markers: evidence from the national health and nutrition examination survey 2009-2018 [0.03%]
2009~2018年美国国家健康与营养调查中饮食质量及饮食炎性潜能与炎性标志物的关系：证据来自NHANES 2009-2018数据
Sida Wang,Yujin Bao,Linning Wang et al.
Sida Wang et al.
Objectives: This study aimed to investigate the independent and joint association of dietary quality and dietary inflammatory potential with four inflammatory markers among U.S. adults and to analyze the moderating role o...
Effects of low-frequency and high-frequency electroacupuncture pretreatment on the COX-2/mPGES-1/PGE2 pathway in a rat model of cold-coagulation dysmenorrhea [0.03%]
低、高频电针预处理对冷凝血块型痛经大鼠模型COX-2/mPGES-1/PGE2通路的影响研究
Yue Song,Jinxia Ni,Jingxue Yuan et al.
Yue Song et al.
Primary dysmenorrhea (PD) refers to a condition in which women experience cyclic lower abdominal pain, often accompanied by lower back pain, and even severe pain and fainting around menstruation, significantly affecting daily activities and...
Multiparametric analysis in the peripheral blood of Giant Cell Arteritis and Polymyalgia Rheumatica patients at the early phases of steroid treatment reveals changes in cell subpopulations and lipid mediators: a preliminary study [0.03%]
初步研究：多参数分析巨细胞动脉炎和多肌痛风湿病患者早期类固醇治疗阶段外周血中的亚群细胞和脂质介质的变化
Dimitris Anastasios Palamidas,Maria Papadaki,Nikolaos Paschalidis et al.
Dimitris Anastasios Palamidas et al.
Introduction: Giant Cell Arteritis (GCA) and Polymyalgia Rheumatica (PMR) are autoimmune/autoinflammatory disorders presenting as acute inflammatory responses and are highly responsive to steroids. In this report, we aim ...