Case Report: Combined umbilical cord blood and peripheral blood stem cell transplantation with donor lymphocyte infusion for R/R AML post CAR-CLL1 failure [0.03%]
脐血和外周血干细胞移植并供者淋巴细胞输注治疗CAR-CLL1方案无效后的复发难治急性髓系白血病病例报告
Fanqiao Meng,Yu Liu,Dongfeng Zeng
Fanqiao Meng
Relapsed/refractory acute myeloid leukemia (R/R AML) carries an extremely poor prognosis, particularly in patients who fail chimeric antigen receptor T-cell (CAR-T) therapy, with no effective treatment options currently available. We report...
Dissecting the multi-omics landscape of TEAD1 in hepatocellular carcinoma: cycle regulation and metastatic potential [0.03%]
TEAD1在肝细胞癌中的多组学景观解析：周期调节和转移潜能
Ruiping Huai,Canquan Mao,Lili Xiong
Ruiping Huai
Background: The effects exerted by the TEA domain transcription factor family genes on tumorigenesis in various cancers have been extensively investigated. Nevertheless, the potential role of TEAD1 in cancer-related epige...
Impact of vitamin D supplementation in the prognosis of patients with SARS-CoV2 pneumonia admitted to the intensive care unit - a randomized controlled trial [0.03%]
维生素D补充对SARS-CoV2肺炎重症患者预后影响的随机对照试验
Ana Moura Gonçalves,Bárbara Sucena Rodrigues,Maria Lobo Antunes et al.
Ana Moura Gonçalves et al.
Background: Research suggests that patients with low vitD levels are more susceptible to severe SARS-CoV-2 infections with need for hospitalization and admission to an intensive care unit (ICU). Our objectives were to eva...
LKB1 regulates ILC3 postnatal development and effector function through metabolic programming [0.03%]
LKB1通过代谢编程调控ILC3的发育及效应功能
Huasheng Zhang,Linfeng Zhao,Qingbing Zhang et al.
Huasheng Zhang et al.
Introduction: Group 3 Innate Lymphoid Cells (ILC3s) are important for maintaining intestinal homeostasis and host defense. Emerging studies have shown that metabolic regulation plays a crucial role in regulating ILC3 acti...
Xiaolan Wu,Qizhi Liu,Zhili Jiang et al.
Xiaolan Wu et al.
Ovarian cancer(OC) is the second most common gynecological malignancy worldwide. While traditional treatments such as cytoreductive surgery, chemotherapy, and targeted drugs have made progress, patients with advanced disease still face high...
The fusion subunit vaccine L-DBF protects aged mice against heterologous lethal Shigella challenge after prior exposure [0.03%]
融合亚单位疫苗L-DBF可在先前暴露的基础上保护老龄小鼠免受异源致死性痢疾杆菌的攻击
Md Shafiullah Parvej,Ti Lu,Suhrid Maiti et al.
Md Shafiullah Parvej et al.
Shigellosis is among the top causes of bacterial diarrhea with significantly high morbidity and mortality for children under five years of age in low- and middle-income countries. Unfortunately, there are currently no licensed vaccines to p...
High-expression of BCL10 inhibits cell-mediated immunity within the tumor immune microenvironment [0.03%]
BCL10高表达通过抑制肿瘤免疫微环境中的细胞介导的免疫反应促进结直肠癌进展
Jinyi Gu,Changshun Chen,Yuanjing Chen et al.
Jinyi Gu et al.
Background: B-cell lymphoma 10 (BCL10) is a key signaling molecule that plays a pivotal role in activating the NF-κB signaling pathway. However, it is unclear whether prolonged activation of BCL10 within tumors lead to T...
Targeting inflammatory macrophages with hyaluronan tetrasaccharide: effects on fibroblast collagen degradation and synthesis [0.03%]
透明质酸四糖靶向炎症巨噬细胞：对成纤维细胞胶原蛋白降解和合成的影响
Eiko Uno,Florence Kim,Mihoko Yoshino et al.
Eiko Uno et al.
Hyaluronan (HA) provides moisturizing benefits and exhibits unique biological activities based on its molecular weight. While the anti-inflammatory effects of high-molecular-weight HA have been well studied, the impact of hyaluronan tetrasa...
VSIG4 as a tumor-associated macrophage marker predicting adverse prognosis in diffuse large B-cell lymphoma [0.03%]
VSIG4作为肿瘤相关巨噬细胞标志物预测弥漫性大B细胞淋巴瘤不良预后
Dongshen Ma,Yubo Wang,Qingqing Shen et al.
Dongshen Ma et al.
Introduction: Diffuse large B-cell lymphoma (DLBCL) exhibits heterogeneous tumor microenvironment. However, the role of tumor-associated macrophages (TAMs) in the DLBCL tumor microenvironment remains unclear. This study a...
Low dose radiotherapy combined with immune checkpoint inhibitors induces ferroptosis in lung cancer via the Nrf2/HO-1/GPX4 axis [0.03%]
低剂量放疗联合免疫检查点抑制剂通过Nrf2/HO-1/GPX4轴诱导肺癌铁死亡
Jing Luo,Qiongjie Zhi,Dongxia Li et al.
Jing Luo et al.
Background: Immune checkpoint inhibitors (ICI) have revolutionized the therapeutic direction for lung cancer, yet their response rates remain unsatisfactory. Recently, the combination of ICI and low dose radiotherapy (LDR...