Single-cell sequencing reveals dysregulated cell type perturbations and critical mediator communication remodelling in colorectal cancer [0.03%]
单细胞测序揭示结直肠癌中失调的细胞类型扰动和关键介质通讯重塑
Chengyuan Xu,Siqi Zhang,Zhouyu Zhang et al.
Chengyuan Xu et al.
Background: The heterogeneity of colorectal cancer (CRC) and its complex immune microenvironment pose significant challenges for treatment. Understanding the cellular composition and dynamic changes is essential for uncov...
Bibliometric and visualized analysis of global distribution and research frontiers in tumor immune escape [0.03%]
全球肿瘤免疫逃逸研究的分布及热点的 bibliometric 和可视化分析
Chaihong Zhang,Lihong Chen
Chaihong Zhang
Background: Tumor cells employ various mechanisms to evade detection and attack by the immune system, a phenomenon known as tumor immune escape, which represents a significant target for immunotherapy. Both primary and se...
Brucella infection induces chromatin restructuring in host cells to activate immune responses [0.03%]
布鲁氏菌感染通过诱导宿主细胞染色质重塑来激活免疫反应
Dejian Xie,Heling Xu,Changwei Su et al.
Dejian Xie et al.
Background: Brucella spp., facultative intracellular pathogens that cause brucellosis, drive pathogenesis by invading host cells and establishing intracellular persistence. While their molecular mechanisms are well-charac...
Identifying early blood glucose trajectories in sepsis linked to distinct long-term outcomes: a K-means clustering study with external validation [0.03%]
基于K-均值聚类的早期血流动力学轨迹在预测脓毒症患者远期结局中的作用研究
Huan Ma,Xiayan Qian,Xiaodong Song et al.
Huan Ma et al.
Background: Blood glucose (BG) dysregulation, including hyperglycemia, hypoglycemia and increased glycemic variability (GV), is common in septic patients and potentially associated with poor clinical outcomes. However, th...
Impaired SREBP1-mediated regulation of lipid metabolism promotes inflammation in chronic endometritis [0.03%]
SREBP1介导的脂质代谢紊乱促进慢性子宫内膜炎炎症进展
Shigeru Matsuda,Yoshimitsu Kuwabara,Yoshitaka Taketomi et al.
Shigeru Matsuda et al.
Chronic endometritis (CE) is an inflammatory disease of the uterus that is associated with infertility and poor reproductive outcomes. Although most cases of CE are attributed to bacterial infections, antibiotic treatment is sometimes ineff...
A novel mitochondrial autophagy and aging-related gene signature for predicting ovarian cancer [0.03%]
一种新的线粒体自噬和衰老相关基因标志物用于预测卵巢癌
Hongyu Zhang,Qiaoying Jin,Huijuan Cao et al.
Hongyu Zhang et al.
Ovarian cancer (OC) is a highly malignant gynecologic tumor with a poor prognosis. In recent years, mitochondrial autophagy and aging (MiAg) have been recognized as crucial pathophysiological mechanisms leading to tumorigenesis. However, th...
Case Report: Disseminated leishmaniasis and rheumatoid arthritis: navigating a clinical conundrum [0.03%]
病例报告：利什曼病和类风湿关节炎：临床难题的应对
Endrit Shahini,Donatello Marziliano,Francesco Losito et al.
Endrit Shahini et al.
Background: Leishmaniasis is a potentially life-threatening protozoan infection that presents with many clinical manifestations, including cutaneous, mucocutaneus and visceral forms. In patients with rheumatoid arthritis ...
Multidisciplinary analysis of the prognosis and biological function of NUBPL in gastric cancer [0.03%]
NUBPL在胃癌预后及功能中的多学科分析研究
Luqian Liu,Fengyu Zhang,Jiaye Yu et al.
Luqian Liu et al.
Background: Researchers are currently concentrating on molecular markers and potential therapeutic targets associated with gastric cancer in light of recent developments in precision medicine and molecular biology. Disulf...
Continuous remission of single-mode therapy with pembrolizumab plus chemotherapy in locally advanced hypopharyngeal carcinoma: a case report [0.03%]
派姆单抗联合化疗持续治疗晚期下咽癌一例报告
Guoning Yu,Jianqiao He,Yingna Gao et al.
Guoning Yu et al.
Hypopharyngeal carcinoma, one of the common malignant tumors of the head and neck, is associated with high tumor aggressiveness, early cervical lymph node metastasis, and a poor prognosis. Neoadjuvant immunotherapy has been gradually introd...
Editorial: Biomimetics and immuno-informed biomaterials: a functional role in immune response and in vivo reprogramming [0.03%]
述评：生物仿生和免疫启发型生物材料：在免疫反应和体内重编程中的功能作用
Santanu Kaity,Manjari Singh,Prem Kumar Govindappa et al.
Santanu Kaity et al.