Construction and evaluation of a Salmonella minicell-based dendritic cell-targeted multi-epitope vaccine against Helicobacter pylori [0.03%]
一种用于靶向树突状细胞的幽门螺旋杆菌多表位疫苗的构建及评价
Jiaxue Yang,Kehan Chen,Yalan Zhu et al.
Jiaxue Yang et al.
Background: Helicobacter pylori (H. pylori) infection is a global health concern linked to various gastrointestinal diseases, highlighting the urgent need for effective vaccines. ...
Cellular hierarchy framework based on single-cell and bulk RNA sequencing reveals fatty acid metabolic biomarker MYDGF as a therapeutic target for ccRCC [0.03%]
基于单细胞和批量RNA测序的细胞层次结构框架揭示了脂肪酸代谢生物标志物MYDGF是ccRCC的治疗靶点
Ning Wang,Ziyu Xu,Lina Zhang et al.
Ning Wang et al.
Background: Fatty acid metabolism (FAM) reprogramming is a prominent feature of clear cell renal cell carcinoma (ccRCC). Nevertheless, the effect of FAM reprogramming on the heterogeneity and prognosis of ccRCC individual...
Axl inhibitor-mediated reprogramming of the myeloid compartment of the in vitro tumor microenvironment is influenced by prior targeted therapy treatment [0.03%]
靶向治疗前期治疗会影响体外肿瘤微环境中髓样组分的AXL抑制剂介导重编程
Anisha Datta,Laura C Bahlmann,Diana N Gong et al.
Anisha Datta et al.
Axl, a member of the receptor tyrosine kinase family comprised of Tyro3, Axl, and MerTK, is a promising cancer therapeutic target actively under clinical investigation. Axl is understood to be a dual target in cancer to (1) prevent tumor ce...
T cell subsets in cervical cancer tumor microenvironment: advances and therapeutic opportunities [0.03%]
宫颈癌肿瘤微环境中的T细胞亚群：进展与治疗机会
Weilin Guo,Lan Dai,Lihua Qiu
Weilin Guo
Cervical cancer is the third most common malignancy among Chinese women in both incidence and mortality. Its progression is closely linked to complex interactions among immune cells within the tumor microenvironment (TME). As key components...
A survey of diagnosis and therapy of inborn errors of immunity among practice-based physicians and clinic-based pneumologists and hemato-oncologists [0.03%]
基于实践的医师和肺科及血液肿瘤科临床医生对先天性免疫缺陷诊断与治疗的调查
Thomas Lehrnbecher,Alexandra Russo,Gernot Rohde
Thomas Lehrnbecher
Identification of key genes in membranous nephropathy and non-alcoholic fatty liver disease by bioinformatics and machine learning [0.03%]
生物信息学和机器学习在膜性肾病与非酒精性脂肪肝疾病关键基因识别中的应用
Jiachen Fan,Na Li,Yanfang Lu et al.
Jiachen Fan et al.
Background: Chronic kidney disease (CKD) and non-alcoholic fatty liver disease (NAFLD) are closely associated. However, membranous nephropathy (MN), one of the causes of CKD, may contribute to NAFLD through abnormalities ...
Use of anakinra in cryopyrin-associated periodic syndromes: case report and review of literature [0.03%]
安卡拉应用于冷吡啉相关周期综合征的病例报告和文献复习
Marta Salas Sánchez,Elena García-Martínez,Héctor Balastegui Martín et al.
Marta Salas Sánchez et al.
Cryopyrin-associated periodic syndrome is a rare autoinflammatory syndrome caused by a dysregulation of cytokine signaling pathways, particularly of the interleukin-1β production. Symptoms typical appear early in life and include recurrent...
Targeting metabolic reprogramming to overcome immune tolerance in melanoma immunotherapy [0.03%]
靶向代谢重编程以克服免疫耐受改善黑色素瘤免疫治疗
Qinchen Wang,Lei Shi,Daoming Shi et al.
Qinchen Wang et al.
Significant advances in the treatment of melanoma, the most aggressive form of skin cancer, have been achieved via immunotherapy. Despite these improvements, therapeutic resistance remains a formidable challenge, compromising the treatment ...
Integrated machine learning and single-cell RNA sequencing reveal COL4A2 and CXCL6 as oxidative stress-associated biomarkers in periodontitis [0.03%]
整合机器学习和单细胞RNA测序揭示COL4A2和CXCL6是牙周病相关氧化应激生物标志物
Siyu Sun,Jing Ren,Xiujuan Zeng et al.
Siyu Sun et al.
Background: Periodontitis, recognized as the second most prevalent oral disease globally, is strongly linked to systemic disorders like diabetes and cardiovascular diseases, highlighting the critical need for effective pr...
Anti-inflammatory and anti-rejection effects of herbal medicine ingredients in organ transplantation: a systematic review and meta-analysis [0.03%]
基于器官移植的中药活性成分抗炎和抗排斥效应的系统评价和meta分析
Jingru Lin,Zhennan Wu,Huazhen Liu et al.
Jingru Lin et al.
Background: Although postoperative rejection in transplant patients can be managed with immunosuppressants, their use is associated with some complications due to excessive immunosuppression. Recent animal studies in allo...