Trained autologous cytotoxic T-cells derived from PBMCs or splenocytes for immunotherapy of neuroblastoma [0.03%]
源自外周血单个核细胞或脾细胞的训练自体细胞毒T细胞用于神经母细胞瘤免疫治疗
Xiaofang Wu,Mousumi Basu,Sarah L Wright et al.
Xiaofang Wu et al.
Background: Pediatric solid tumors, particularly neuroblastoma, present significant treatment challenges due to the limited efficacy of existing therapies. Adoptive immunotherapy, which involves transferring immune cells ...
Commentary: Induction of hepatic fibrosis in mice with schistosomiasis by extracellular microRNA-30 derived from Schistosoma japonicum eggs [0.03%]
日本血吸虫卵来源的胞外微小核糖核酸-30诱导小鼠肝纤维化的机制研究
Haoran Zhong,Yamei Jin
Haoran Zhong
Discovery and development of a safe and efficient COVID-19 mRNA vaccine, STP2104, using a novel capping library screening method [0.03%]
使用新型帽子文库筛选方法发现并开发一种安全高效的COVID-19 mRNA疫苗STP2104
Kanghyun Choi,Joo-Young Lee,Uk-Il Kim et al.
Kanghyun Choi et al.
Messenger RNA (mRNA) vaccines represent a critical avenue for coronavirus disease 2019 (COVID-19) prevention. We developed a COVID-19 mRNA vaccine encoding a codon-optimized full-length ancestral spike (S) protein with a signal peptide, whi...
Development of a machine learning-derived dendritic cell signature for prognostic stratification in lung adenocarcinoma [0.03%]
开发用于肺癌腺癌预后分层的机器学习衍生的树突细胞标志物
Fang Zhou,Meng Wang,Zheng Wang et al.
Fang Zhou et al.
Background: Lung adenocarcinoma (LUAD), the most common histological subtype of lung cancer, demonstrates significant intertumoral heterogeneity. While dendritic cells (DCs) are essential mediators of antitumor immunity, ...
A noteworthy issue: microbiome data variation depending on sampling methods in skin microecology studies in acne vulgaris patients [0.03%]
值得关注的问题：采样方法对痤疮患者皮肤微生态研究中菌群数据的影响分析
De-Tian Xu,Qi Chen,Jia-Yi Yang et al.
De-Tian Xu et al.
Introduction: Skin microecology significantly affects health, with the microbiome being a complex community of microorganisms. Different niche preferences of microorganisms raise concerns about the adequacy of common samp...
LDH and glycolytic activity as predictors of immunotherapy response in gastric cancer: a systematic review and meta-analysis [0.03%]
胃癌免疫治疗反应的乳酸脱氢酶和糖酵解活性预测因素的系统评价和meta分析
Li Zhu,Juanjuan Ruan,Qing Zhang et al.
Li Zhu et al.
Background: Immune checkpoint inhibitors (ICIs) have transformed gastric cancer (GC) treatment, but response heterogeneity necessitates reliable prognostic biomarkers. This meta-analysis investigates the predictive value ...
Extraction of anthocyanins from purple sweet potato: evaluation of anti-inflammatory effects in a rheumatoid arthritis animal model, mechanistic studies on inflammatory cells, and development of exosome-based delivery for enhanced targeting [0.03%]
从紫甘薯中提取花青素：在类风湿关节炎动物模型中的抗炎效果评估、炎症细胞机制研究及外泌体递送系统开发以增强靶向性
Jingjian Dong,Yuntao Lv,Cailiang Zhao et al.
Jingjian Dong et al.
Objective: Rheumatoid arthritis (RA) is a chronic autoimmune disease marked by inflammation and joint damage. Anthocyanins, such as those from purple sweet potato are known for their anti-inflammatory effects. ...
Atherosclerosis: from lipid-lowering and anti-inflammatory therapies to targeting arterial retention of ApoB-containing lipoproteins [0.03%]
动脉粥样硬化：从降脂和抗炎治疗到以载脂蛋白B为目标的治疗方法
Gala Araujo,Leidy Marian Valencia,Agata Martin-Ozimek et al.
Gala Araujo et al.
Atherosclerosis is a chronic inflammatory disease characterized by the accumulation of lipids, fibrous elements, and cellular debris in the blood vessels. The response-to-retention hypothesis, the leading theory on the pathogenesis of this ...
Explainable machine learning reveals ribosome biogenesis biomarkers in preeclampsia risk prediction [0.03%]
可解释机器学习发现核糖体生物发生标志物用于子痫前期风险预测
Jingjing Chen,Dan Zhang,Chengxiu Zhu et al.
Jingjing Chen et al.
Background: Preeclampsia, a hypertensive disorder during pregnancy affecting 2-8% of pregnancies globally, remains a leading cause of maternal and fetal morbidity. Current diagnostic reliance on late-onset clinical featur...
Pseudomonas aeruginosa-derived metabolites and volatile organic compounds: impact on lung epithelial homeostasis and mucosal immune response [0.03%]
铜绿假单胞菌的代谢产物和挥发性有机化合物对气道上皮稳态及黏膜免疫反应的影响
Shanny Hsuan Kuo,Gee W Lau
Shanny Hsuan Kuo
Pulmonary diseases, such as cystic fibrosis (CF), chronic obstructive pulmonary disease (COPD), and ventilator-associated pneumonia (VAP), are attributed to the prolonged infection of the airway and hypersecretion of mucus. Pseudomonas aeru...