Nanoparticle approaches for manipulating cytokine delivery and neutralization [0.03%]
用于操纵细胞因子递送和中和的纳米颗粒方法
Rui Wang,Luke J Kubiatowicz,Runhe Zhang et al.
Rui Wang et al.
Cytokines are crucial regulators of inflammation and immune tolerance, making them promising targets for treating immune-related diseases like cancer, infections, and autoimmune disorders. While cytokine-based therapies have shown potential...
B cell-extrinsic and intrinsic factors linked to early immune repletion after anti-CD20 therapy in patients with multiple sclerosis of African ancestry [0.03%]
非洲血统多发性硬化症患者接受抗CD20治疗后早期免疫恢复与B细胞的外在和内在因素有关
Gregg J Silverman,Abhimanyu N Amarnani,Arnaldo A Armini et al.
Gregg J Silverman et al.
Introduction: Recent investigations have identified patients of African ancestry (AA) with Multiple Sclerosis (MS), who display more rapid B-cell repopulation after standard semi-annual infusions with an anti-CD20 monoclo...
Regulation of actin cytoskeletal dynamics in T cell development and function [0.03%]
肌动蛋白细胞骨架在T细胞发育和功能中的调节作用
Trang T Lam,Mark M W Chong
Trang T Lam
T cell development and function depend on precise remodeling of the actin cytoskeleton, which regulates migration, cell division, immunological synapse formation, and signal transduction. Regulators of actin include nucleators (Arp2/3, Form...
Case Report: Serum sickness induced by dupilumab-clinical insights and Olinkproteomic analysis [0.03%]
达普利马布诱导的药物超敏反应（血清病）-临床特征及Olink蛋白组分析
Hongguo Zhu,Qian&#x;e Huang,Linhong Zheng et al.
Hongguo Zhu et al.
Dupilumab is a humanized monoclonal antibody that targets interleukin-4 (IL-4) and IL-13 pathways, commonly used in the treatment of various inflammatory conditions. Despite its therapeutic efficacy, it can also lead to rare adverse reactio...
Multiple sclerosis: etiology in the context of neurovascular unit and immune system involvement and advancements with in vitro blood-brain barrier models [0.03%]
从神经血管单元和免疫系统参与的角度探讨多发性硬化症的病因以及体外血脑屏障模型的发展与应用
Aya A El-Taibany,Parichehr Heydarian,Daniel A Porada et al.
Aya A El-Taibany et al.
Multiple sclerosis affects a significant portion of the world's adult population and is the most common nontraumatic neuroimmunology disorder. Although the specific etiology of multiple sclerosis remains unknown, it has been associated with...
Single-cell ligand-receptor profiling reveals an immunotherapy-responsive subtype and prognostic signature in triple-negative breast cancer [0.03%]
单细胞配体-受体谱分析揭示了三阴性乳腺癌的可免疫治疗亚型和预后标志物
Chuanzhi Chen,Jiahui Qi,Weichao Lin et al.
Chuanzhi Chen et al.
Background: Triple-negative breast cancer (TNBC) is an aggressive form of cancer that lacks specific targeted therapies. Although ligand-receptor (LR) interactions play a crucial role in intercellular communication and co...
Distinct metabolomic signatures in allergic rhinitis with concurrent chronic spontaneous urticaria: an untargeted metabolomics analysis reveals novel biomarkers and pathway alterations [0.03%]
伴发慢性自发性荨麻疹的过敏性鼻炎具有独特的代谢组特征：无目标代谢组分析发现新的生物标志物和通路改变
Xiaohong Lyu,Yi Liu,Huaijun Zheng et al.
Xiaohong Lyu et al.
Background: Although allergic rhinitis (AR) and chronic spontaneous urticaria (CSU) share overlapping immunological pathways, their distinct clinical manifestations imply the involvement of unique underlying mechanisms. T...
Editorial: Host-pathogen interactions during pregnancy: mechanisms of maternal and fetal immunity [0.03%]
编者按：妊娠期间宿主病原菌互作：母体和胎儿免疫机制
Yael Alippe,Vanesa Hauk,Gil Mor et al.
Yael Alippe et al.
WTAP modulates macrophage polarization in rheumatoid arthritis by targeting exosomal circ-CBLB via m6A modification [0.03%]
WTAP通过m6A修饰靶向外泌体circ-CBLB调节类风湿关节炎中巨噬细胞极化
Dawei Yan,Lei Wan
Dawei Yan
Introduction: Interactions between fibroblast-like synoviocytes (FLSs) and macrophages are pivotal in the pathogenesis of rheumatoid arthritis (RA). Exosomal circular RNAs (circRNAs) are key players in the communication b...
Alternative splicing of KLF4 in myeloid cells: implications for cellular plasticity and trained immunity in cancer and inflammatory disease [0.03%]
髓系细胞中KLF4的可变剪接：其对癌症和炎症性疾病中的细胞弹性和训练免疫的影响
Amanda Rosewell Shaw,Attoria Bennett,Daping Fan et al.
Amanda Rosewell Shaw et al.
The role of transcription factor Krüppel-like factor 4 (KLF4) in the modulation of myeloid cells is well known. KLF4 is involved in the differentiation and polarization of monocytes and macrophages as part of the immune response after infe...