Protective effects for HLA-B*40:01 and C*03:04 in NPM1-mutated AML: result of a large HLA association study [0.03%]
大型HLA关联研究显示NPM1突变型急性髓系白血病的保护性HLA-B*40：01和C*03：04
Elke Rücker-Braun,Bose Falk,Henning Baldauf et al.
Elke Rücker-Braun et al.
Introduction: Mutations in the nucleophosmin 1 gene (NPM1) are common and recurrent molecular abnormalities in acute myeloid leukemia (AML). NPM1 mutations are considered to be positive prognostic factors. The beneficial ...
Editorial: The current state of knowledge on asthma-COPD overlap (ACO) in clinical and experimental research: what do we know so far? [0.03%]
述评：临床和实验研究中哮喘慢性阻塞性肺病重叠症(ACO)的现状：我们目前了解多少？
Fernanda Degobbi Tenorio Quirino Dos Santos Lopes,Iolanda de Fátima Lopes Calvo Tibério,Renato Fraga Righetti
Fernanda Degobbi Tenorio Quirino Dos Santos Lopes
Targeting the ferroptosis pathway for rheumatoid arthritis: molecular mechanisms and prospects for inhibitor development [0.03%]
靶向铁死亡途径治疗类风湿关节炎：分子机制与抑制剂开发前景
Zhuoling Wang,Xinyue Bai,Huahua Zhang et al.
Zhuoling Wang et al.
Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease with severe complications. Ferroptosis, an iron-dependent form of apoptosis, encompasses mechanisms including iron overload, lipid peroxidation, redox homeostasis, and react...
Integrated analysis of exosome-related genes and their role in psoriasis pathogenesis [0.03%]
外泌体相关基因的综合分析及其在银屑病发病机制中的作用研究
Zhen Wang,Fang Luo
Zhen Wang
Objective: This study aimed to analyze gene expression data from psoriasis and control samples, focusing on identifying exosome and cell senescence genes, integrating datasets, and validating batch effect removal using pr...
Microbiome profiling reveals gut bacterial species associated with rapid lung function decline in people with HIV [0.03%]
微生物组分析揭示了HIV感染者快速肺功能下降相关的肠道细菌种类
Xiangning Bai,Sajan C Raju,Andreas Dehlbæk Knudsen et al.
Xiangning Bai et al.
Background: People with HIV (PWH) have an increased risk of pulmonary comorbidities compared to people without HIV. The gut microbiome regulates host immunity and is altered in PWH. This study aims to determine potential ...
Research progress on composite nerve guidance conduits with immune-regulatory functions [0.03%]
具有免疫调节功能的复合神经导管的研究进展
Shuxuan Zhang,Xinyue Sun,Xuewa Yang et al.
Shuxuan Zhang et al.
Peripheral nerve injury (PNI) has emerged as a critical clinical challenge due to its high disability rate and socioeconomic burden. Traditional autologous nerve grafting, limited by donor shortages and risks of secondary surgeries, has dri...
Conversion therapy with TACE, TKIs, and ICIs for unresectable BCLC stage B and C hepatocellular carcinoma [0.03%]
不可切除的巴塞罗那肝癌分期B期和C期肝细胞癌的TACE、TKI及ICI联合治疗转换疗法
Zhuoran Wang,Cunzhen Zhang,Jianhua Yin et al.
Zhuoran Wang et al.
Background and aims: Most Hepatocellular carcinoma (HCC) diagnoses occur at advanced stages precluding radical surgical resections. Conversion therapy offers a viable chance for patients with unresectable HCC (uHCC) to be...
Clinical Trial
Frontiers in immunology. 2025 Jun 10:16:1451965. DOI:10.3389/fimmu.2025.1451965 2025
Hao Liu,Dujuan Zhou,Yangjing Ou et al.
Hao Liu et al.
Lung cancer is a prevalent malignant tumor and the leading cause of cancer-related mortality worldwide. LC is a complex respiratory condition that poses significant challenges for both clinicians and researchers. Crucially, dysregulation of...
Construction of a novel inflammatory-related prognostic signature of acute myelocytic leukemia based on conjoint analysis of single-cell and bulk RNA sequencing [0.03%]
基于单细胞和批量RNA测序联合分析构建急性髓系白血病新型炎症相关预后标志物
Yongfen Huang,Ping Yi,Yixuan Wang et al.
Yongfen Huang et al.
Introduction: The prognostic management of acute myeloid leukemia (AML) remains a challenge for clinicians. This study aims to construct a novel risk model for AML patient through comprehensive analysis of scRNA and bulk ...
Sirtuin 5 inhibits mitochondrial metabolism in liver cancer cells and promotes apoptosis by mediating the desuccinylation of CS [0.03%]
Sirtuin 5通过介导天冬氨酸转氨酶去琥珀化抑制肝癌细胞的线粒体代谢并促进其凋亡
Huimin Cao,Dongsheng Wei,Han Li et al.
Huimin Cao et al.
Background: Citrate synthase (CS) is a key rate-limiting enzyme in the tricarboxylic acid (TCA) cycle and plays a crucial role in cancer progression. However, the mechanism by which CS promotes liver cancer growth remains...