Siyuan Wen,Tianli Feng,Yu Fan
Siyuan Wen
Breast cancer is the most common malignant tumor in women, ranking first globally in both incidence and mortality rates among female malignancies, posing a severe threat to women's physical and mental health. Neutrophils are recognized as t...
Prognostic and immunological implications of cathepsin Z overexpression in prostate cancer [0.03%]
猫hepsin Z过表达在前列腺癌中的预后及免疫学意义研究
Junyue Tao,Yiding Chen,Xiaokang Bian et al.
Junyue Tao et al.
Background: Recent studies have underscored the potential involvement of cathepsin Z (CTSZ) in modulating the progression of diverse tumor types. Nevertheless, its specific role in prostate cancer (PCa) remains insufficie...
PANoptosis in neurological disorders: mechanisms, implications, and therapeutic potential [0.03%]
泛优化在神经障碍中的机制、影响和治疗潜力
Jingyi Li,Yi Qu
Jingyi Li
PANoptosis is a unique form of programmed cell death (PCD) that has the combined main features of pyroptosis, apoptosis, and necroptosis, but cannot be fully explained by any single pathway alone. Among all the influencing factors in PANopt...
Human saliva exerts strong type-dependent effects on adenovirus infectivity [0.03%]
人唾液对腺病毒的感染性产生强烈且类型依赖的效果
Erwan Sallard,Wenli Zhang,Nikita Chilakamarri et al.
Erwan Sallard et al.
Background: The development of mucosal adenovirus (Ad) vaccine vectors is considered one of the next frontiers to protect vulnerable patients from respiratory and gastrointestinal pathogens. An efficient delivery to or th...
Expression and correlation of SOCS3 and Eotaxin mRNA and proteins levels in nasal mucosal tissue of allergic rhinitis patients [0.03%]
过敏性鼻炎患者鼻黏膜组织SOCS3及Eotaxin mRNA和蛋白表达及其相关性研究
Zhaopeng Kang,Lian Xu,Ping Ai et al.
Zhaopeng Kang et al.
Objective: This study aims to investigate the expression and interaction mechanisms of Suppressor of Cytokine Signaling 3 (SOCS3) and Eotaxin in the nasal mucosal tissues of patients with Allergic Rhinitis (AR). ...
Silica-calcium phosphate nanoparticles delivering recombinant influenza hemagglutinin DNA can induce long-lasting T cell immune cross-protection in mice [0.03%]
二氧化硅-钙磷酸盐纳米颗粒递送重组流感血凝素DNA可以诱导小鼠产生持久的T细胞交叉保护免疫响应
Xiaoxi Liu,Qingyu Wang,Yuhua Shi et al.
Xiaoxi Liu et al.
Introduction: Vaccination remains one of the key tools to prevent influenza pandemic. The influenza vaccine induces durable cross-subtype protection through T-cell immunity, demonstrating significant future potential. DNA...
A novel molecule targeting neutrophil-mediated B-1a cell trogocytosis attenuates sepsis-induced acute lung injury [0.03%]
一种针对中性粒细胞介导的B-1a细胞trogocytosis的新分子可减轻脓毒症引起的急性肺损伤
Yuichi Akama,Jespar Chen,Alok Jha et al.
Yuichi Akama et al.
Sepsis is a dysregulated immune response to infection. B-1a cells play a crucial role in maintaining immuno-physiologic homeostasis. Sialic acid-binding immunoglobulin-like lectin G (Siglec-G) regulates B-1a cell's behavior and function. Tr...
Plasma proteomic profiling of hospitalized patients co-infected with HIV and SARS-CoV-2 [0.03%]
HIV和SARS-CoV-2共感染住院患者的血浆蛋白质组特征分析
Xinyu Zhang,Xuan Yan,Jinfeng Sun et al.
Xinyu Zhang et al.
Background: The interaction between human immunodeficiency virus (HIV) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections presents a critical challenge to immunopathogenesis. While HIV infection i...
IL-17A drives a fibroblast-neutrophil-NET axis to exacerbate immunopathology in the lung with diffuse alveolar damage [0.03%]
肺泡损伤中白细胞介素-17A驱动成纤维细胞-中性粒细胞-胞外诱捕网轴以加重免疫病理学损害
Duo Su,Lu Li,Hao Xie et al.
Duo Su et al.
Diffuse alveolar damage (DAD), a lethal manifestation of acute lung injury, remains a critical public health concern due to the absence of targeted therapies. However, the underlying cellular and molecular mechanisms responsible for immunop...
Peripheral blood inflammatory score using a cytokine multiplex assay predicts clinical outcomes in patients treated with atezolizumab-bevacizumab for unresectable HCC [0.03%]
外周血细胞因子多重检测炎性评分用于阿特朱单抗-贝伐珠单抗治疗不可切除肝癌患者的预后判断
Hee Sun Cho,Soon Kyu Lee,Ji Won Han et al.
Hee Sun Cho et al.
Background: Several serum cytokines have been proposed as biomarkers for predicting the outcomes of patients with hepatocellular carcinoma (HCC) receiving tyrosine kinase inhibitors. However, their role in atezolizumab pl...