Multi-omics-based subtyping of melanoma suggests distinct immune and targeted therapy strategies [0.03%]
基于多组学的黑色素瘤亚型分类提出了不同的免疫和靶向治疗策略
Changchang Li,Xiaoqiong Lin,Jinhui Wang et al.
Changchang Li et al.
Background: Melanoma is a highly heterogeneous malignancy with diverse molecular and clinical behaviors. A precise molecular classification is critical for improving prognostic assessment and guiding personalized therapy....
The gut-immune axis in primary immune thrombocytopenia (ITP): a paradigm shifts in treatment approaches [0.03%]
原发免疫性血小板减少症(ITP)中的肠-免疫轴：治疗策略的范式转变
Xuejun Guo,Ke Wang,Qianhui Liu et al.
Xuejun Guo et al.
Primary immune thrombocytopenia (ITP) is an autoimmune disorder characterized by platelet destruction and impaired production, leading to bleeding risk. While immunosuppressive therapies are standard, many patients experience relapses or re...
Ruxolitinib in adult dermatomyositis with anti-TIF1γ antibody: a case report and literature review [0.03%]
鲁索利替尼治疗成人抗TIF1γ抗体阳性皮肌炎的疗效及机制：一例报告和文献复习
Xu Jing,Wang Min,Liu Xia et al.
Xu Jing et al.
Ruxolitinib is a selective JAK1/2 inhibitor, and its application in treating adult-onset dermatomyositis(DM) has rarely been described. Here, we report a case of an adult-onset DM patient with anti-TIF1γ antibody, who also suffered from es...
PA/MR imaging-guided precision phototherapy and efficacy evaluation of hepatocellular carcinoma utilizing a targeted multifunctional nanoprobe [0.03%]
基于PA/MR成像的肝癌精准光动力诊疗及疗效评价研究——靶向多功能纳米探针的应用
Shuo Qi,Lei Zhou,Weinan Liu et al.
Shuo Qi et al.
Introduction: Early-stage hepatocellular carcinoma (HCC) poses a significant challenge due to its poor prognosis, necessitating advancements in diagnostic and therapeutic strategies. The integration of near-infrared photo...
Immunotherapy targeting liver cancer tumor-initiating cells: challenges, mechanisms, and emerging therapeutic horizons [0.03%]
靶向肝癌肿瘤起始细胞的免疫治疗：挑战、机制及新兴治疗前景
Yinying Chai,Tinghui Xu,Xin Chen et al.
Yinying Chai et al.
Liver cancer is a major global health burden, with hepatocellular carcinoma (HCC) being the most common type. Liver cancer tumor-initiating cells (TICs) are responsible for recurrence, metastasis, and therapeutic resistance, thereby present...
Risk scoring model for lung adenocarcinoma based on PD-L1 related signature reveals prognostic predictability and correlation with tumor immune microenvironment genes was constructed [0.03%]
基于PD-L1相关标志物构建肺腺癌风险评分模型可揭示其预后预测价值及与肿瘤免疫微环境基因的相关性
Meng Li-Fei,Si-Meng Ren,Jun Wang et al.
Meng Li-Fei et al.
Background: Immunotherapy has recently become a hot topic in the field of oncology, with PD-L1 playing a crucial role in this area. However, the research on PD-L1 correlation prediction models is not fully understood. The...
The heterogeneity of genomic alterations, metastatic patterns and immune microenvironment in metastatic ovarian cancer originating from colorectal cancer [0.03%]
起源于结直肠癌的卵巢转移癌的基因组改变、转移模式和免疫微环境异质性研究
Chao Chen,Jian Wang,Binjie Sun et al.
Chao Chen et al.
Purpose: The ovarian metastases originating from colorectal cancer (CRCOM) develops rapidly and lethally. Previously, the genetic alterations and metastatic pathway in CRCOM were not well understood. The aim of this study...
Dual function of Gasdermin E: pyroptosis-mediated pan-cancer suppression versus HCC-specific oncogenic activity [0.03%]
Gasdermin E的双重功能：在泛癌中通过调控细胞焦亡发挥抑癌作用，在肝癌中特异性促癌作用
Gulijiamali Kahaer,Sirun Pan,Chengcheng Yang et al.
Gulijiamali Kahaer et al.
Gasdermin E (GSDME), a key executor of pyroptosis, exerts a unique dual role in tumorigenesis, acting as both a tumor suppressor and a tumor-promoting factor. Due to promoter hypermethylation, GSDME is epigenetically silenced in most solid ...
Tongwang Yang,Zhiyun Gu,Juan Feng et al.
Tongwang Yang et al.
Non-neoplastic chronic liver diseases (CLDs), including alcoholic liver disease, metabolic-associated fatty liver disease, viral hepatitis, fibrosis, and cirrhosis, pose a global health challenge due to progressive fibro-inflammatory remode...
Utilization of artificial circular RNAs as miRNA sponges and anti-PD-1 scFv expression platforms to suppress hepatocellular carcinoma progression [0.03%]
人工circRNA的体内递送及其作为miRNA海绵和抗PD-1单链抗体表达平台抑制肝癌进展的功能研究
Yongping Lai,Fei Wang,Guang Cai et al.
Yongping Lai et al.
Background: Hepatocellular carcinoma (HCC) is characterized by a complex interplay of genetic and epigenetic alterations that contribute to its aggressive nature and resistance to conventional therapies. The recent advent...