Cross-cohort multi-omics analysis identifies novel clusters driven by EMT signatures in colorectal cancer [0.03%]
跨队列多组学分析识别出EMT特征驱动的结直肠癌新型亚型集群
Wu Ning,Wenqing Jia,Jingyuan Ning et al.
Wu Ning et al.
Introduction: The pronounced heterogeneity of colorectal cancer (CRC) significantly impacts patient prognosis and therapeutic response, making elucidation of its molecular mechanisms critical for developing precision trea...
Immune monitoring and risk of infection in pediatric liver transplantation: a prospective study [0.03%]
儿童肝移植的免疫监测和感染风险：一项前瞻性研究
Ricardo Cuesta-Martín de la Cámara,Laura Miguel-Berenguel,Carmen Cámara et al.
Ricardo Cuesta-Martín de la Cámara et al.
Background: Immune monitoring has been proposed to optimize immunosuppressive therapy in liver recipients. This study aims to describe immunological changes following liver transplantation in pediatric recipients and to i...
Induction chemoimmunotherapy may achieve non-inferior outcomes to consolidation immunotherapy in patients with unresectable stage III NSCLC: a real-world multicenter retrospective study [0.03%]
诱导化疗免疫治疗可能不劣于序贯巩固免疫治疗用于不可手术的III期NSCLC患者：一项真实世界多中心回顾性研究
Song Guan,Yu Wang,Qing Liu et al.
Song Guan et al.
Background: Consolidation immunotherapy after chemoradiotherapy (CRT) is the standard of care for unresectable stage III non-small cell lung cancer (NSCLC). However, the role of upfront chemoimmunotherapy before CRT remai...
Multicenter Study
Frontiers in immunology. 2025 Jun 12:16:1591134. DOI:10.3389/fimmu.2025.1591134 2025
Alessandra Buoninfante,Marco Cavaleri
Alessandra Buoninfante
Vaccines are complex biological medicinal products developed with the aim to generate protective immunity against specific infectious diseases in a particular target population. Regulatory authorities, who have the role of approving vaccine...
Atopic dermatitis and risk of autoimmune diseases: a systematic review and meta-analysis [0.03%]
特应性皮炎与自身免疫性疾病风险的相关性：系统评价和-meta-分析
Hongli Wang,Min Chen,Tengyue Wang et al.
Hongli Wang et al.
Background: Atopic dermatitis (AD) is a common recurrent chronic inflammatory skin disease, and there is increasing evidence of a possible association between AD and autoimmune diseases. ...
Single cell dissection reveals SFRP2+ fibroblasts amplifying inflammatory responses in oral lichen planus [0.03%]
单细胞分析发现SFRP2+成纤维细胞可增强口腔扁平苔藓的炎症反应
Juehua Cheng,Jia Liu,Yuchi Zhu et al.
Juehua Cheng et al.
Objectives: Oral lichen planus (OLP) is a chronic inflammatory mucosal disease with an incompletely understood pathogenesis. This study aimed to investigate the role of disease-specific fibroblasts in OLP. ...
Generating tumor-specific T cells based on a head and neck cancer organoid for adoptive cell therapy [0.03%]
基于头颈部癌类器官生成肿瘤特异性T细胞用于过继性细胞治疗
Yinyu Chen,Shoupeng Wang,Luxi Zheng et al.
Yinyu Chen et al.
Background: A head and neck cancer organoid (HNCO) and peripheral blood T cell co-culture model was established to investigate whether HNCOs can induce the differentiation of peripheral blood T cells into tumor-reactive T...
PD-1 inhibitor-augmented HAIC-TKI therapy in hepatocellular carcinoma with portal vein tumor thrombosis: real-world survival benefits, safety, and subgroup-specific efficacy [0.03%]
经血管介入化疗联合酪氨酸激酶抑制剂及程序性死亡受体-1抑制剂治疗门静脉瘤栓肝细胞癌的现实世界疗效、安全性及其亚组人群特征分析
Fei Cao,Chunyong Wen,Yujia Wang et al.
Fei Cao et al.
Background: PD-1/PD-L1 inhibitors have shown efficacy in improving the prognosis of patients with hepatocellular carcinoma (HCC) accompanied by portal vein tumor thrombosis (PVTT) in pivotal clinical trials including the ...
Cancer cell-derived extracellular vesicles: a potential target for overcoming tumor immunotherapy resistance and immune evasion strategies [0.03%]
癌细胞来源的外泌体：克服肿瘤免疫疗法抵抗和免疫逃避策略的潜在靶点
Minseo Ahn,Jeong-Geon Mun,Yohan Han et al.
Minseo Ahn et al.
Extracellular vesicles (EVs), including exosomes and microvesicles, play crucial roles in cancer progression by mediating the communication between cancer cells and their microenvironment. Cancer cell-derived EVs promote tumor growth, metas...
Efficacy and safety of TACE combined with lenvatinib and PD-1 Inhibitor in intermediate-stage HCC exceeding the up-7 criteria: a retrospective cohort study [0.03%]
超UP-to-7标准的中期肝癌患者经动脉化疗栓塞联合仑伐替尼和PD-1抑制剂的疗效及安全性：回顾性队列研究
Miao Xue,Yanqin Wu,Yiyang Tang et al.
Miao Xue et al.
Purpose: This study aimed to assess the efficacy and safety of combining transarterial chemoembolization (TACE) with lenvatinib and a PD-1 inhibitor (TACE+LEN+PD-1) compared to TACE combined with lenvatinib alone (TACE+LE...