ScRNA-seq combined with ATAC-seq analysis to explore the metabolic balance mechanism of CCl4-induced liver inflammatory injury [0.03%]
结合单细胞RNA测序和ATAC测序探索四氯化碳诱导肝炎代谢平衡机制
Hui Liu,Yisha Zhang,Shoubin Ning
Hui Liu
Background: Drug-induced liver injury (DILI) can provoke inflammation and fibrosis in the liver, potentially leading to severe liver diseases and mortality; however, effective treatments for liver fibrosis remain elusive....
The role of T-helper and T regulatory cells in driving neutrophilic and eosinophilic inflammation in bronchiectasis [0.03%]
支气管扩张中T辅助细胞和T调节细胞在驱动中性粒细胞和嗜酸性粒细胞炎症中的作用
Evangelia Fouka,Anders Lindén,Apostolos Bossios
Evangelia Fouka
Bronchiectasis is a chronic airway disease characterized by dysbiosis, persistent inflammation, and permanent structural airway damage. Neutrophilic inflammation is a key pathogenic feature, as indicated by enhanced neutrophil-derived prote...
Targeting oxidative stress in diabetic retinopathy: mechanisms, pathology, and novel treatment approaches [0.03%]
糖尿病视网膜病变的氧化应激治疗：机制、病理和新型治疗方法
Wei He,Panli Tang,Hongbin Lv
Wei He
Diabetic retinopathy (DR) is a common and severe microvascular complication of diabetes, leading to vision impairment and blindness, particularly in working-age adults. Oxidative stress plays a central role in the pathogenesis of DR, with e...
Machine learning-driven prediction of immune checkpoint inhibitor responses against cholangiocarcinoma: a bile biopsy perspective [0.03%]
基于机理学习的免疫检查点抑制剂用于治疗胆管癌应答预测：一种胆汁活检的新视角
Dengyong Zhang,Xinrui Li,Zhonglin Wang et al.
Dengyong Zhang et al.
Background: The treatment of cholangiocarcinoma (CCA) continues to face numerous clinical challenges, including the prediction of sensitivity to immunotherapy and the development of preoperative diagnostic models. ...
Sex-specific cytokine signatures as predictors of anti-PD1 therapy response in non-small cell lung cancer [0.03%]
预测非小细胞肺癌抗PD-1治疗反应的性别细胞因子谱特征
Catherine Taylor,Ammar Sabir Cheema,Karama Asleh et al.
Catherine Taylor et al.
Background: The introduction of immune checkpoint inhibitors (ICI) as first-line therapy in the treatment of non-small cell lung cancer has dramatically improved response rates. However, more than half of NSCLC patients r...
Osteopontin as a diagnostic and NTZ-response biomarker of multiple sclerosis: a systematic review and meta-analysis [0.03%]
骨基质蛋白作为诊断和二甲基呋喃(F2)反应生物标志物的多发性硬化症：系统回顾和荟萃分析
Adela González-Jiménez,Elena Urcelay,Laura Espino-Paisán
Adela González-Jiménez
Introduction: Multiple sclerosis (MS) is a neuroinflammatory complex disease of the central nervous system (CNS). Diagnosing MS remains challenging due to its nonspecific signs, highlighting the need for reliable biomarke...
PD-1/PD-L1 inhibitor-induced hyponatremia: a real-world pharmacovigilance analysis using FAERS database [0.03%]
基于FAERS数据库的PD-1/PD-L1抑制剂所致低钠血症的药物警戒分析
Chao Tao,Bingyao Liu,Yan Dai et al.
Chao Tao et al.
Background: With the increasing use of programmed cell death protein 1 and programmed cell death ligand 1 (PD-1/PD-L1) inhibitors in cancer treatment, hyponatremia has emerged as a notable adverse event associated with th...
Deciphering the role of signal regulatory protein α in immunotherapy for solid tumors [0.03%]
信号调节蛋白α在实体瘤免疫治疗中的作用机制研究
Yulong Zhou,Xiyang Tang,Weiguang Du et al.
Yulong Zhou et al.
Therapies targeting immune checkpoints like programmed death receptor-1 and programmed death ligand-1 have demonstrated remarkable effectiveness in combating cancer. However, a subset of patients fails to respond to these therapies, undersc...
The role of innate immune responses against two strains of PEDV (S INDEL and non-S INDEL) in newborn and weaned piglets inoculated by combined orogastric and intranasal routes [0.03%]
联合口服和鼻内接种产肠毒大肠杆菌(S-INDEL和非S-INDEL株)后新生仔猪与断奶仔猪的先天免疫反应作用规律研究
C López-Figueroa,E Cano,N Navarro et al.
C López-Figueroa et al.
Introduction: Porcine epidemic diarrhea (PED) is a severe gastrointestinal disease in swine caused by PED virus (PEDV), leading to significant economic losses worldwide. Newborn piglets are especially vulnerable, with nea...
Dandan Wang,Hao Rong,Ke Ma et al.
Dandan Wang et al.
Lactate, a central product of glucose metabolism, plays a vital role in energy supply and signal transduction, and it also participates in gene transcription regulation through lactylation. Metabolic reprogramming is a key feature of tumor ...