The reprogramming factor KLF4 in normal and malignant blood cells [0.03%]
转录因子KLF4在正常及恶性血液细胞中的功能和机制研究
H Daniel Lacorazza
H Daniel Lacorazza
The Krüppel-like factor 4 (KLF4) is an evolutionarily conserved zinc finger transcription factor that regulates cellular processes in stem cells, epithelial cells, and immune blood cells by controlling gene expression through genetic, epig...
Developmental immune network of airway lymphocytes and innate immune cells in patients with stable COPD [0.03%]
慢性阻塞性肺疾病患者气道淋巴细胞和固有免疫细胞的发育免疫网络
Lanlan Liu,Mei Zhou,Shengwen Sun et al.
Lanlan Liu et al.
Introduction: Chronic obstructive pulmonary disease (COPD) is characterized by persistent airway inflammation and immune dysfunction. However, the molecular alterations and precise origins of immune cells in COPD airways ...
Hydroxychloroquine enhances efferocytosis and modulates inflammation via MerTK/Gas6 signaling in a pristane-induced lupus mouse model [0.03%]
羟氯喹通过MerTK/Gas6信号增强磷脂酰丝氨酸介导的吞噬作用并调节肺鼠模型中的炎症反应
Shin-Yi Liu,Yung-Ju Yeh,Ting-Yin Xue et al.
Shin-Yi Liu et al.
Background: Hydroxychloroquine (HCQ) is a frontline treatment for autoimmune diseases, including rheumatoid arthritis, Sjogren's syndrome, and systemic lupus erythematosus (SLE), due to its potent immunomodulatory propert...
Therapeutic implications of cancer-associated fibroblast heterogeneity: insights from single-cell and multi-omics analysis [0.03%]
单细胞和多组学分析揭示的肿瘤相关成纤维细胞异质性的治疗意义
YuMin Wang,Yi Ding,HaoLin Liu et al.
YuMin Wang et al.
Background: Cancer-associated fibroblasts (CAFs) are essential components of the tumor microenvironment (TME), contributing to tumorigenesis, progression, and resistance to therapy. However, the functional diversity of CA...
Dynamics of oxylipin biosynthesis in systemic inflammation: insights from a large animal model of endotoxemia [0.03%]
内毒素血症大型动物模型中系统性炎症下氧脂素生物合成的动力学规律：新的研究见解
Madison N Myers,Miguel Chirivi,Jose M Dos Santos Neto et al.
Madison N Myers et al.
Introduction: Endotoxemia, marked by the presence of bacterial lipopolysaccharide (LPS) in the bloodstream, induces acute inflammation and is implicated in both mortality and chronic disease across species. LPS stimulates...
Efficacy of iguratimod in the treatment of patients with palindromic rheumatism ineffective to methotrexate or hydroxychloroquine [0.03%]
甲氨蝶呤或羟氯喹疗效不佳的回纹型类风湿患者应用伊加鲁替莫德治疗的有效性研究
Mengjie Chen,Yongjun Cheng,Guiyao Jin et al.
Mengjie Chen et al.
Introduction: Palindromic Rheumatism (PR) is a rare form of arthritis characterized by recurrent episodes of joint and periarticular inflammation. Given the paucity of established treatment guidelines due to its rarity an...
Transcriptomic and proteomic signatures of host NK cells delineate distinct immune states across tuberculosis infection statuses [0.03%]
转录组和蛋白质组特征界定了结核病不同感染状态下的宿主NK细胞免疫状态
Han Zhang,Liguo Liu,Jie Hu et al.
Han Zhang et al.
Introduction: Although natural killer (NK) cells play crucial roles in the immune response to Mycobacterium tuberculosis (M.tb) infection, systematic investigations delineating the immune characteristics of NK cells acros...
Sphingosine-1-phosphate stimulates colorectal cancer tumor microenvironment angiogenesis and induces macrophage polarization via macrophage migration inhibitory factor [0.03%]
鞘氨醇-1-磷酸刺激结直肠癌肿瘤微环境血管生成并通过巨噬细胞移行抑制因子诱导巨噬细胞极化
Fang Wu,Zhaode Feng,Xuan Wang et al.
Fang Wu et al.
Background: Colorectal cancer (CRC) is the most common gastrointestinal malignancy with extensive reprogramming of sphingolipid metabolism. However, the role and mechanisms of sphingosine-1-phosphate (S1P), a key bioactiv...
A novel and safe SmartCap® SC101 to develop the COVID-19 mRNA vaccine STP2104 inducing potent immune responses in humans [0.03%]
一种新颖且安全的SmartCap®SC101，用于开发可诱导人类强烈免疫反应的COVID-19mRNA疫苗STP2104
Rachel Kim,Tae-Gi Uhm,Jisu Kim et al.
Rachel Kim et al.
We have developed a 5'-capping library screening (CLS) method using over 30 different novel cap analogues. The optimal 5'-cap for the coronavirus disease 2019 (COVID-19) mRNA vaccine STP2104 was selected and applied. This is the first repor...
Clinical Trial
Frontiers in immunology. 2025 Jun 16:16:1571092. DOI:10.3389/fimmu.2025.1571092 2025
m6A modification: a novel mechanism that regulates atherosclerosis via macrophage polarization [0.03%]
m6A修饰通过巨噬细胞极化调节动脉粥样硬化的新型机制研究
Xiaying Li,Hengkai Zhang,Yan Zhou et al.
Xiaying Li et al.
Atherosclerosis is a chronic vascular inflammatory disease in which macrophages play a pivotal role in modulating its pathology. In response to the intraplaque microenvironment, both pro-inflammatory M1 and anti-inflammatory M2 phenotypes o...