Exploring the differential functions of circulating follicular helper T and peripheral helper T cells in rheumatoid arthritis based on metabolism patterns [0.03%]
基于代谢模式探讨循环滤泡辅助T细胞和外周辅助T细胞在类风湿关节炎中功能差异性
Ziran Bai,Siwen Yang,Jinyi Ren et al.
Ziran Bai et al.
Introduction: The number of circulating follicular helper T (cTfh) and peripheral helper T (Tph) cells is elevated in rheumatoid arthritis (RA), yet the molecular mechanisms mediating their specific contributions to RA pa...
Precision prognostication in neuroblastomas via clinically validated E2F activity signatures [0.03%]
通过临床验证的E2F活性标志物进行神经母细胞瘤的精准预后判断
Donghan Cai,Huihuang Xu,Shiwei He et al.
Donghan Cai et al.
Background: Neuroblastoma (NB) is the most common extracranial solid tumor in children, with high-risk NB (HR-NB) exhibiting dismal survival rates due to aggressive biology and therapy resistance. E2F transcription factor...
Inhibition of the Na+-glucose transporter SGLT2 reduces glucose uptake and IFNγ release from activated human CD4+ T cells [0.03%]
钠-葡萄糖协同转运蛋白2抑制剂通过减少血糖吸收和活化的人CD4+T细胞中IFNγ释放来降低血糖水平
Zhe Jin,Hayma Hammoud,Amol K Bhandage et al.
Zhe Jin et al.
Glucose uptake in activated CD4+ T cells is essential for increased metabolic needs, synthesis of biomolecules and proliferation. Although, facilitated glucose transport is the predominant route for glucose entry at the time of activation, ...
Decoding the etiology of immune-mediated inflammatory diseases statistically [0.03%]
利用统计学方法解析自身免疫性炎症性疾病的病因
Hesham ElAbd,Aya K H Mahdy
Hesham ElAbd
Immune-mediated inflammatory diseases (IMIDs) are incurable pathologies with an increased prevalence. Whereas different risk factors for IMIDs have been identified, such as microbial dysbiosis, diet, Epstein-Barr virus infection, the exact ...
Metabolomic insights into variable antihistamine responses in allergic rhinitis: unveiling biomarkers for precision treatment [0.03%]
代谢组学视角下过敏性鼻炎患者抗组胺药物反应差异性的研究：揭示精准治疗生物标志物的新见解
Xiaohong Lyu,Yi Liu,Hongna Li et al.
Xiaohong Lyu et al.
Background: The clinical response to antihistamine therapy exhibits substantial heterogeneity among individuals with allergic rhinitis (AR). While these medications represent a cornerstone in AR management, the molecular ...
The diagnostic and prognostic role of novel biomarkers in anti-neutrophil cytoplasmic antibody-associated vasculitis [0.03%]
新型生物标志物在抗中性粒细胞胞浆抗体相关性血管炎诊断和预后中的作用
Ruohan Yu,Lina Zhang,Jing Zhang et al.
Ruohan Yu et al.
Background: ANCA-associated vasculitis (AAV) is a group of autoimmune diseases characterized by small vessel inflammation, diagnosed primarily through clinical features, histopathology, and ANCA testing. Novel biomarkers ...
The clinical features, muscle pathology, and role of autophagy in anti-Ku-positive patients [0.03%]
抗Ku阳性患者的临床特征、肌肉病理和自噬作用的影响
Lingya Qiao,Ying Lin,Mengyang Liu et al.
Lingya Qiao et al.
Aims: This study aimed to examine the clinical and muscle histological characteristics of anti-Ku-positive patients. A preliminary investigation into the involvement of autophagy was conducted as well. ...
The PE/PPE family proteins of Mycobacterium tuberculosis: evolution, function, and prospects for tuberculosis control [0.03%]
结核分枝杆菌的PE/PPE蛋白家族：起源、功能和控制结核病的意义
Zhijing Zhang,Le Dong,Xin Li et al.
Zhijing Zhang et al.
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), remains a leading global health threat, exacerbated by drug resistance and inadequate vaccine efficacy. The PE/PPE protein family, unique to mycobacteria, constitutes ~10% of th...
Editorial: Viral impact on CNS: mechanisms of immune dysfunction and cognitive decline [0.03%]
述评：病毒对CNS的影响：免疫功能障碍和认知能力下降的机制
Thomas A Angelovich,Sonia Mediouni,Robyn S Klein et al.
Thomas A Angelovich et al.
A comprehensive review of IgG4-related pancreatitis: pathogenesis, diagnosis, and therapeutic advances [0.03%]
IgG4相关性胰腺炎综合述评：发病机制、诊断及治疗进展
Siqin Wu,Xiaowen Qin,Zhenjing Jin et al.
Siqin Wu et al.
IgG4-related pancreatitis (IRP) is a form of chronic pancreatitis characterized by the infiltration of IgG4-positive plasma cells, representing a pancreatic manifestation of IgG4-related disease (IgG4-RD). In recent years, with the growing ...