Immunogenicity of therapeutic peptide products: bridging the gaps regarding the role of product-related risk factors [0.03%]
治疗性肽产品的免疫原性：关于产品相关风险因素作用的缺口分析
Montserrat Puig,Sophie Shubow
Montserrat Puig
The global market for therapeutic peptides is projected to continue to grow at a fast pace in the coming years in response to high demand for these products. The increasing complexity of chemical and recombinant peptide manufacturing proces...
Subtype-specific atypical B cell profiles in myasthenia gravis reveal distinct immunopathological pathways [0.03%]
重症肌无力中B细胞亚型特异性的非典型谱型揭示了不同的免疫病理途径
Patricia M Sikorski,Henry J Kaminski,Angela Vincent et al.
Patricia M Sikorski et al.
Introduction: Atypical B cell (atBC) subsets display significant heterogeneity across autoimmune diseases, complicating efforts to define their role and therapeutic potential. We hypothesized that this heterogeneity refle...
ER stress genes (COL1A1, LOXL2, VWF) predicts IKK-16 as a Candidate therapeutic target for colitis-related inflammation and fibrosis suppression [0.03%]
ER应激基因（COL1A1、LOXL2、VWF）预测IKK-16可作为治疗候选靶点以抑制与结肠炎相关的炎症和纤维化
Ke Zhang,Jiao Yang,Qing-Qing Yang et al.
Ke Zhang et al.
Introduction: The role of endoplasmic reticulum stress (ERS) in the immune-inflammatory dysregulation and intestinal fibrosis associated with ulcerative colitis (UC) remains unclear. This study aims to identify ERS-relate...
Mesoporous silica nanoparticles loaded Au nanodots: a self-amplifying immunotherapeutic depot for photothermal immunotherapy [0.03%]
负载金纳点的介孔二氧化硅纳米颗粒：用于光热免疫治疗的自放大型免疫治疗储库
Chuan Wang,Dongmei Wang,Liang Huang et al.
Chuan Wang et al.
Introduction: Photothermal therapy (PTT) has emerged as a highly promising approach for cancer treatment due to its advantages of localized treatment, controllable irradiation, and non-invasive nature. This study presents...
Evolving fitness and immune escape: a retrospective analysis of SARS-CoV-2 spike protein (2020-2024) using protein language model [0.03%]
SARS-CoV-2刺突蛋白（2020-2024）的适应性进化和免疫逃逸：基于蛋白质语言模型的回顾性分析
Sihua Peng,Leke Lyu,Ludy Registre Carmola et al.
Sihua Peng et al.
Introduction: The COVID-19 pandemic posed global health challenges. Understanding SARS-CoV-2's evolutionary dynamics, especially fitness and immune escape, is vital for public health. This study uses protein language mode...
PABPN1 as a pan-cancer biomarker: prognostic significance and association with tumor immune microenvironment [0.03%]
PABPN1作为泛癌症生物标志物：预后意义及与肿瘤免疫微环境的关系
Hong-Xing Li,Xiao-Ling Ma,Wang-Bin Ma et al.
Hong-Xing Li et al.
Objective: This study aimed to investigate the role of poly(A) binding protein nuclear 1 (PABPN1) as a potential pan-cancer biomarker for prognosis and immunotherapy. ...
Integrative multi-omics analysis of IFNγ-induced macrophages and atherosclerotic plaques reveals macrophage-dependent STAT1-driven transcription in atherosclerosis [0.03%]
整合多组学分析IFNγ诱导的巨噬细胞和动脉粥样硬化斑块，揭示STAT1介导的转录在动脉粥样硬化中的巨噬细胞依赖性作用
Mahdi Eskandarian Boroujeni,Natalia Lopacinska,Aleksandra Antonczyk et al.
Mahdi Eskandarian Boroujeni et al.
Atherosclerosis is a chronic inflammatory disease of blood vessels, characterized by atherosclerotic lesions in large- and medium-sized arteries. IFNγ is a crucial mediator of atherosclerosis through activation of signal transducer and act...
The efficacy and safety of tislelizumab with or without tyrosine kinase inhibitor as adjuvant therapy in hepatocellular carcinoma with high-risk of recurrence after curative resection [0.03%]
替雷利珠单抗联合或不联合酪氨酸激酶抑制剂作为治愈性手术后复发高风险的肝细胞癌患者的辅助治疗的有效性和安全性
Ning Peng,Lin-Feng Mao,Jia-Yong Su et al.
Ning Peng et al.
Background: Multiple studies have demonstrated that adjuvant therapy with programmed death-1 (PD-1) inhibitors can enhance the recurrence-free survival of patients with hepatocellular carcinoma (HCC) following curative re...
Multicenter Study
Frontiers in immunology. 2025 Jun 18:16:1593153. DOI:10.3389/fimmu.2025.1593153 2025
Hairong Xiao,Kai Yang
Hairong Xiao
Macrophages, as essential components of the immune system, play pivotal roles in regulating neuroimmune interactions. These cells exist in two primary forms: tissue-resident macrophages and monocyte-derived macrophages (MDMs), each exhibiti...
Using technology for patient-centered care at home after CAR T-cell therapy or stem cell transplant: a prospective feasibility study [0.03%]
家庭护理技术在CAR-T细胞治疗或干细胞移植后的应用：一项前瞻性可行性研究
Susan L Moore,Glen J Peterson,Sarah R Montoya et al.
Susan L Moore et al.
Introduction: Febrile neutropenia, neurotoxicity, and cytokine release syndrome are dangerous and damaging side effects seen in more than half of patients with cancer who receive critical chemotherapies or immunotherapies...