Interplay between tumor cells and immune cells of the colorectal cancer tumor microenvironment: Wnt/β-catenin pathway [0.03%]
结肠直肠癌肿瘤微环境内肿瘤细胞和免疫细胞的相互作用：Wnt/β-连环蛋白信号通路
Aisha Saleh Janeeh,Khuloud Bajbouj,Bilal Rah et al.
Aisha Saleh Janeeh et al.
Colorectal cancer (CRC) is currently ranked as the third most frequent human cancer and the fourth leading cause of cancer-related deaths worldwide. Macrophages and immune cell subsets infiltrate the tumor microenvironment (TME) and modulat...
In evolution's unending race: ancestral STING sensors in Salmo salar mediate intracellular bacterial detection and programmed cell death through evolutionarily conserved pathways [0.03%]
在进化无尽的竞赛中：_salmo salar_ 的祖先 STING 感应器通过保守途径介导胞内细菌检测和程序性细胞死亡
Alejandro J Yañez,Jorge F Beltrán,Claudia A Barrientos et al.
Alejandro J Yañez et al.
Introduction: "In evolution's unending race, survival demands continuous adaptation- to stop is to fall behind." The Stimulator of Interferon Genes (STING) pathway embodies this principle, acting as a conserved master reg...
Peptidoglycan derived from Lacticaseibacillus rhamnosus and Lactobacillus acidophilus suppress TLR2/1-mediated inflammation in bovine endometrial epithelial cells [0.03%]
乳酸菌乳糖乳杆菌和嗜酸乳杆菌衍生的肽聚糖可通过抑制牛子宫内膜上皮细胞中TLR2/1介导的炎症反应发挥抗炎作用
Elham Waehama,Kenji Fukuda,Alireza Mansouri et al.
Elham Waehama et al.
Bacteria and associated products are factors in the pathogenesis of bovine endometrial inflammation, contributing to reproductive dysfunction. While peptidoglycan derived from Staphylococcus aureus (PGN-Sa) has been demonstrated to induce p...
Antiretroviral therapy initiated during acute infection in women with HIV-1 clade C reduces anti-Tat antibody production and lowers CD8+ T cell activation [0.03%]
在感染HIV-1型C组的妇女中急性感染期间开始抗逆转录病毒治疗可减少抗Tat抗体产生并降低CD8+T细胞活化水平
Thandeka I Kubheka,Kewreshini Naidoo,Kavidha Reddy et al.
Thandeka I Kubheka et al.
Introduction: The HIV-1 Tat protein is essential for virus replication and spread and is therefore a potential target for anti-HIV therapy. Anti-Tat antibodies have been shown to slow HIV disease progression and improve a...
Case Report: Pediatric age onset CNTN1 antibody-associated neuropathy with nephropathy and literature review [0.03%]
病例报告：儿科年龄起病CNTN1抗体相关神经病变伴肾病及文献综述
Ceyda Bayraktar Eltutan,Simon Rinaldi,Atay Vural et al.
Ceyda Bayraktar Eltutan et al.
We present a 12-year-old boy with acute onset sensorimotor neuropathy and membranous glomerulonephritis associated with contactin-1 antibodies. This prompted us to explore the clinical characteristics of this condition and assess whether it...
Expansion of CD103+CD69+CD8+ cytotoxic liver tissue resident memory T cells and inflammatory monocytes in advanced biliary atresia [0.03%]
胆道闭锁晚期肝组织驻留记忆T细胞和炎性单核细胞的扩张
Freya Sibbertsen,Regine J Dress,Sören Alexander Weidemann et al.
Freya Sibbertsen et al.
Introduction: The pathogenesis of biliary atresia (BA) is unclear to date and no therapies targeting immune regulatory pathways exist. Here we characterized potent effector liver tissue resident memory CD8+ T cells (Trm) ...
Decoding neuroinflammation in Alzheimer's disease: a multi-omics and AI-driven perspective for precision medicine [0.03%]
阿尔茨海默病神经炎症的多组学和人工智能驱动的精准医学视角解读
Shiyu Lin,Yijun Zhan,Ruiqi Wang et al.
Shiyu Lin et al.
Alzheimer's disease (AD) is a common neurodegenerative disease, which is characterized by β-amyloid (Aβ) deposition, Tau hyperphosphorylation, synaptic dysfunction and chronic neuroinflammation. Despite significant advances in research in...
Functional feed ingredients modulate the immune response of RTgutGC cells to LPS-induced inflammation [0.03%]
功能性饲料成分可调节RTgutGC细胞对脂多糖诱导炎症的免疫反应
Malene Malchus Fosse,Laura Rivera Méndez,Tania Rodríguez-Ramos et al.
Malene Malchus Fosse et al.
Functional feed ingredients can enhance the fish gut integrity and immune resilience during challenging situations in the aquaculture industry. This study used the RTgutGC cell line - derived from rainbow trout intestinal epithelium, to eva...
Characterization and functional evaluation of JS207, a novel bispecific antibody against human PD-1 and VEGFA [0.03%]
一种新型人源PD-1/VEGFA双特异性抗体JS207的表征及功能评价
Shihua Lin,Min Hong,Jing Zhang et al.
Shihua Lin et al.
Introduction: Cancer immunotherapy has been revolutionized by targeting PD-1 to restore antitumor T-cell activity and blocking VEGF to attenuate immunosuppressive tumor angiogenesis. While combining PD-1 and VEGF inhibiti...
BioBERT-powered synergy: advanced bibliometric and molecular insights into prostate cancer bone metastasis [0.03%]
利用BioBERT优势协同效应：前列腺癌骨转移的高级引文计量学和分子机制研究
Zile Liu,Zexin Chen,Kangyi Xue et al.
Zile Liu et al.
Background: Prostate cancer (PC) is a leading cause of male cancer mortality, with bone metastasis (BM) being a frequent and debilitating complication. Despite therapeutic advancements, the molecular mechanisms underlying...