Molecular insights into glioblastoma progression: role of CHCHD2P9 in tumor heterogeneity and prognosis [0.03%]
CHCHD2P9在胶质母细胞瘤异质性和预后中的作用及其对肿瘤进展的分子见解
Yanyu Ding,Lizhi Xiao,Xiaoling Zhou et al.
Yanyu Ding et al.
Background: Gliomas are highly aggressive, life-threatening tumors with poor prognosis, and remain a leading cause of mortality among brain cancers. Although the role of mitochondrial proteins in cancer has garnered incre...
The role of notch signaling pathway in cancer: mechanistic insights, therapeutic potential, and clinical progress [0.03%]
诺特信号通路在癌症中的作用：机制见解、治疗潜力和临床进展
Haokun Zhang,Wang Hang,ZhaoHui Jing et al.
Haokun Zhang et al.
This article presents a comprehensive literature review on the role of the Notch signaling pathway in cancer and its molecular mechanisms. The Notch signaling pathway plays an important role in various types of cancer by regulating key biol...
Zebrafish models in glioma research: advances in methodologies, mechanistic insights, and therapeutic frontiers [0.03%]
斑马鱼在胶质瘤研究中的模型应用：方法学、机制及治疗方面的进展
Runchao Tao,Junying Qu,Jing Zhao et al.
Runchao Tao et al.
Glioma is the most common primary malignant brain tumor, which faces great challenges in clinical treatment due to its high invasiveness and resistance to existing treatments. In recent years, the zebrafish model has gradually become an imp...
Reprogramming of glucose metabolism in pancreatic cancer: mechanisms, implications, and therapeutic perspectives [0.03%]
胰腺癌中葡萄糖代谢重编程的机制、意义及治疗前景
Yan Zhang,Wancheng Li,Jubao Niu et al.
Yan Zhang et al.
As a typical pathological feature of pancreatic ductal adenocarcinoma, reprogramming of glucose metabolism synergistically drives the tumorigenesis and development process through molecular mechanisms such as regulating the expression of dr...
Utilizing plasma exchange for severe cytokine release syndrome after CAR-T cell therapy: clinical experience and literature insights [0.03%]
CAR-T细胞治疗后利用血浆置换治疗重症细胞因子释放综合征的临床经验及文献见解
Jiasi Zhang,Dali Xie,Meiyan Tang et al.
Jiasi Zhang et al.
Cytokine release syndrome (CRS) is a severe complication following Chimeric Antigen Receptor T-cell (CAR-T) therapy, characterized by an excessive inflammatory response triggered by the activation of CAR-T cells. Clinically, approaches like...
Applications and insights from continuous dengue virus infection in a stable cell line [0.03%]
连续登革病毒感染稳定细胞系的应用和见解
M Jane Morwitzer,Ying Yi Zheng,Heather Friberg et al.
M Jane Morwitzer et al.
Dengue is caused by the four serotypes of dengue virus (DENV-1-4) and poses a significant global public health challenge, with an estimated 100-400 million infections annually. Severe dengue manifestations, such as Dengue Hemorrhagic Fever ...
Jamin W Roh,Peter A Barry,Peter W Hunt et al.
Jamin W Roh et al.
Human Cytomegalovirus (HCMV) is a ubiquitous virus with a global prevalence of 90%, but infection typically has minimal clinical impact in immunocompetent individuals. Consequently, most people are neither tested nor treated for HCMV. Howev...
Sineenart Sengyee,Sarah B Weiby,Ivory T Rok et al.
Sineenart Sengyee et al.
Melioidosis, caused by the Gram-negative bacterium Burkholderia pseudomallei, is a severe infectious disease that is responsible for a significant amount of morbidity and mortality in endemic areas. While the majority of melioidosis cases o...
Meta-analysis of the efficacy and safety of rituximab in the treatment of primary Sjögren's syndrome [0.03%]
利妥昔单抗治疗原发性干燥综合征疗效和安全性的 Meta 分析
Xiao Zheng,Jiaoyang Di,Xuexiao Chen et al.
Xiao Zheng et al.
Objective: To methodically assess the effectiveness and safety of rituximab in treating primary Sjögren's syndrome. Methods: The searc...
Taurine-mediated metabolic immune crosstalk indicates and promotes immunosuppression with anti-PD-1 resistance in bladder cancer [0.03%]
牛磺酸介导的代谢免疫交叉对话提示并促进膀胱癌中抗PD-1耐药性的免疫抑制作用
Zhengfang Liang,Fengwei Nong,Zhenjie Li et al.
Zhengfang Liang et al.
Background: Bladder cancer (BLCA) remains heavily dependent on bacillus Calmette-Guérin (BCG) therapy due to the profound heterogeneity of its tumor microenvironment (TME) and deregulated metabolic landscapes. Taurine me...