Cost-effectiveness analysis of cadonilimab plus bevacizumab and chemotherapy for persistent, recurrent, or metastatic cervical cancer [0.03%]
卡度尼利联合贝伐珠单抗与化疗治疗持续、复发或转移性宫颈癌的成本效益分析
Kaixuan Wang,Shixian Liu,Ruixue Wang et al.
Kaixuan Wang et al.
Objective: The aim of this study is to investigate the cost-effectiveness of cadonilimab plus bevacizumab and chemotherapy in the first-line treatment for patients with persistent, recurrent, or metastatic cervical cancer...
Immunogenic cell death-related biomarkers in heart failure probed by transcriptome and single-cell sequencing [0.03%]
转录组和单细胞测序探索心力衰竭中与免疫原性细胞死亡相关的生物标志物
Haoyue Wang,Dongdong Wu,Gangfei Han et al.
Haoyue Wang et al.
Background: Heart failure (HF) represents the terminal stage of various cardiovascular disorders, with immunogenic cell death (ICD) potentially influencing HF progression through modulation of immune cell activity. This s...
Mohamed A Youssef,Hisham Al-Sharif,Brian T McGrath et al.
Mohamed A Youssef et al.
Immunotherapy has shown significant potential for treating malignancies. Not yet widely considered is the opportunity to employ immunotherapy for the treatment of benign tumors. By focusing on targetable antigens expressed following specifi...
Comprehensive immune profiling and predictive modelling of paediatric acute hepatitis of unknown aetiology from a Spanish cohort [0.03%]
西班牙队列中原因不明的儿童急性肝炎的全面免疫谱分析和预测模型构建
Roberto Lozano-Rodríguez,Loreto Hierro,María José Quiles et al.
Roberto Lozano-Rodríguez et al.
Introduction: Paediatric acute hepatitis of unknown aetiology (PAHUA) has emerged as a global health concern, yet its cause remains unidentified. This study characterises the clinical and immunological profiles of PAHUA t...
Donor-derived cell-free DNA and miRNA monitoring for the early prediction and diagnosis of liver allograft rejection and patient outcomes [0.03%]
基于供者来源的细胞游离DNA和miRNA监测进行肝脏移植排异早期预测及诊断
Judit Julian,Olga Millán,Esther Titos et al.
Judit Julian et al.
Introduction: The identification of noninvasive biomarkers for monitoring liver transplant (LT) recipients is crucial for the early detection of graft dysfunction and rejection. Donor-derived cell-free DNA (dd-cfDNA) and ...
Observational Study
Frontiers in immunology. 2025 Jun 24:16:1604200. DOI:10.3389/fimmu.2025.1604200 2025
ISGylation and E3 ubiquitin ligases: an Atlantic salmon genetic perspective [0.03%]
ISGylation和E3泛素连接酶：大西洋鲑鱼的遗传学视角
Unni Grimholt,Hilde Sindre,Arvind Y M Sundaram
Unni Grimholt
Introduction: In mammals, the ubiquitin-proteasomal pathway plays a key role in the host antiviral response by targeting viral genes for degradation. Here, E1-activating enzymes, E2-conjugating enzymes, and E3 ligases att...
Epidemiological characteristics of breakthrough varicella cases among students in Jiulongpo District, Chongqing: implications for vaccination strategies [0.03%]
重庆九龙坡区学生疫苗突破性水痘病例的流行特征及对疫苗策略的启示
Huixian Zhou,Qianjin Long,Hechuan Xie et al.
Huixian Zhou et al.
Objective: This study aimed to investigate the epidemiological characteristics and determinants of breakthrough varicella (BV) cases in student populations, identify key factors influencing breakthrough infection interval...
Dual single-cell and bulk RNA sequencing reveal transcriptional profiles underlying heterogenous host-parasite interactions in human peripheral blood mononuclear cells [0.03%]
双重单细胞和批量RNA测序揭示了人类外周血单个核细胞异质性宿主寄生虫相互作用的转录组谱型
Praveena Chandrasegaran,Bekir Faydaci,Barbara Shih et al.
Praveena Chandrasegaran et al.
Toxoplasma gondii, a zoonotic apicomplexan that infects over a billion people worldwide, can cause early death in immunocompromised individuals and defects in foetal brain development. Toxoplasma is also a major cause of abortion in small r...
Case Report: Two cases of IgG4-related kidney disease with monoclonal gammopathy [0.03%]
病例报告：IgG4相关性肾病合并单克隆免疫球蛋白两例
Qian Dong,Xuanli Tang,Jiang Liu et al.
Qian Dong et al.
Introduction: IgG4-related disease (IgG4-RD) is a newly classified but poorly understood immune-medicated systemic disease. Monoclonal gammopathy encompasses a spectrum of disorders driven by clonal plasma cell proliferat...
Editorial: Immunotherapy resistance and advancing adaptive cell therapeutics [0.03%]
编辑部：免疫治疗耐药与适应性细胞治疗的发展
Luciana Rodrigues Carvalho Barros,Amar Yeware
Luciana Rodrigues Carvalho Barros