Single-cell transcriptome and multi-omics integration reveal ferroptosis-driven immune microenvironment remodeling in knee osteoarthritis [0.03%]
单细胞转录组和多组学整合揭示膝关节炎中铁死亡驱动的免疫微环境重塑
Yushun Wu,Jing Liu,Wenying Yu et al.
Yushun Wu et al.
Background: Knee osteoarthritis (KOA) is a chronic inflammatory joint disorder marked by cartilage degradation and immune microenvironment dysregulation. While transcriptomic studies have identified key pathways in KOA, t...
Investigating the role of tumor cell heterogeneity and angiogenesis genes in the prognosis of multiple myeloma [0.03%]
探究肿瘤细胞异质性和血管生成基因在多发性骨髓瘤预后中的作用
Xue Qiao,Zhengrong Song,Li Geng et al.
Xue Qiao et al.
Background: Multiple myeloma (MM) is a common hematologic malignancy characterized by high tumor cell heterogeneity, which significantly impacts the clinical prognosis of patients. Angiogenesis and the molecular features ...
TREM2 in MASH: integrating lipid metabolism and immune response [0.03%]
髓鞘脱失症患者中的TREM2：脂质代谢与免疫反应的相互作用
Shuyi Shi,Yangyang Zhou,Haiming Zhang et al.
Shuyi Shi et al.
Metabolic dysfunction-Associated Steatohepatitis (MASH), a progressive liver disease characterized by disturbances of lipid metabolism and chronic inflammation response in liver has become the most prevalent chronic liver diseases worldwide...
Identification and validation of CKAP2 as a novel biomarker in the development and progression of rheumatoid arthritis [0.03%]
识别并验证微管结合蛋白CKAP2作为类风湿关节炎发生发展的新型生物标志物
Qiongbing Zheng,Youmian Lan,Jiexin Chen et al.
Qiongbing Zheng et al.
Background: Rheumatoid arthritis (RA) is a common chronic joint disease. However, many patients exhibit inadequate responses to treatment due to disease heterogeneity. Identifying novel biomarkers for RA is crucial for ad...
RNA-sequencing studies suggest that microRNAs and alternative splicing of pre-mRNAs modulate immune and inflammatory responses in Holstein cattle infected with Mycobacterium avium subsp. paratuberculosis [0.03%]
RNA测序研究表明，MicroRNAs和Mycobacterium avium subsp. paratuberculosis感染荷斯坦奶牛的免疫和炎症反应的前mRNA的选择性剪切可对其进行调节
Gerard Badia-Bringué,Marta Alonso-Hearn
Gerard Badia-Bringué
RNA-Sequencing (RNA-Seq) studies using bovine samples from Mycobacterium avium subsp. paratuberculosis (MAP)-infected animals have identified a range of differentially expressed mRNAs with potential as biomarkers for MAP infection. As bioin...
Boosting cancer immunotherapy: drug delivery systems leveraging ferroptosis and immune checkpoint blockade [0.03%]
利用铁死亡和免疫检查点抑制的癌症免疫疗法的药物递送系统研究及其增效作用
Ting Zhang,Fanlin Gu,Wei Lin et al.
Ting Zhang et al.
Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment, significantly improving outcomes for various malignancies. Despite their clinical success, only a subset of patients benefits from ICIs treatment, underscoring the ne...
Multi-omics analysis identified macrophages as key contributors to sex-related differences in ulcerative colitis [0.03%]
多组学分析揭示巨噬细胞在溃疡性结肠炎性别差异中起关键作用
Xiaojie Fang,Jiahao Yang,Liu Yang et al.
Xiaojie Fang et al.
Background: Ulcerative colitis (UC) has a complex etiology, and whether there are sex-related differences in its molecular mechanisms remains unclear. This study employed multi-omics analysis to explore sex-based differen...
Immune responses following DNA vaccination by needle-free injection against Burkholderia pseudomallei hemolysin co-regulated protein 1 [0.03%]
无针注射分枝杆菌伪中间丝质粒Ⅰ型菌毛调控蛋白的DNA疫苗诱导的免疫应答
Michael L Davies,Sergei S Biryukov,Christopher P Klimko et al.
Michael L Davies et al.
Burkholderia pseudomallei is a facultative intracellular bacterium found in soil, which causes melioidosis, a disease with diverse symptomatology. B. pseudomallei is an emerging threat in the United States based on recent environmental samp...
Generation of a new Paneth cell-specific Cre-recombinase transgenic mouse line [0.03%]
一种新型潘氏细胞特异的Cre重组酶转基因小鼠品系的建立
Natalia Garcia-Gonzalez,Charlotte Wallaeys,Wendy Toussaint et al.
Natalia Garcia-Gonzalez et al.
Paneth cells are located in the crypts of Lieberkühn in mammalian small intestines and are producing antimicrobial peptides to keep the microbiome under control. The genetic manipulation of Paneth cells and their tracking and depletion dep...
Investigating the role of soil-transmitted helminth infections in the development of leprosy in endemic regions [0.03%]
土壤传播的线虫感染在流行区患麻风病中的作用研究
Vikram Singh,Ravindra P Turankar,Vinay Kumar Pathak et al.
Vikram Singh et al.
Background: India alone contributes nearly 54% of the global load of new cases of leprosy and 21% to global helminthic parasitic infection cases. Research studies have suggested that Soil-transmitted helminth (STH) infect...