Adherence to therapeutic recommendation in relapsing-remitting multiple sclerosis patients [0.03%]
复发缓解性多发性硬化症患者的治疗依从性研究
Justyna Chojdak-Łukasiewicz,Aleksandra Kołtuniuk,Ewa Sawicka et al.
Justyna Chojdak-Łukasiewicz et al.
Background: Adherence to disease-modifying therapies (DMTs) in multiple sclerosis (MS) is crucial for effective treatment. Understanding the patients' perspective and identification of factors influencing adherence to tre...
Rational therapeutic targeting of myeloid cells in glioblastoma: challenges and perspectives [0.03%]
胶质母细胞瘤中髓系细胞的理性治疗靶向：挑战与展望
Faruk Akay,Maya Saleh
Faruk Akay
Glioblastoma (GB) is the most aggressive tumor of the central nervous system (CNS), accounting for almost 80% of all primary brain tumors. Despite standard-of-care consisting of surgical resection, when possible, adjuvant radiotherapy (RT) ...
A consensus mathematical model of vaccine-induced antibody dynamics for multiple vaccine platforms and pathogens [0.03%]
适用于多种疫苗和病原体的诱导抗体动力学的共识数学模型
Kristen M Wilding,Carmen Molina-París,Jessica Z Kubicek-Sutherland et al.
Kristen M Wilding et al.
Introduction: Vaccine platforms used in successful, licensed vaccines have varied among pathogens. However, antibody level is still the main clinical correlate of protection in most approved vaccines. Decisions as to the ...
Vaccine-induced responses to R21/Matrix-M - an analysis of samples from a phase 1b age de-escalation, dose-escalation trial [0.03%]
R21/Matrix-M疫苗诱导的免疫反应——来自一个阶段1b年龄递减和剂量递增试验样本的分析
Caroline Bundi,Duncan Bellamy,Elizabeth Kibwana et al.
Caroline Bundi et al.
Introduction: The pre-erythrocytic malaria vaccine R21 vaccine adjuvanted with Matrix-M reported good efficacy (75%) in an ongoing phase 3 trial and was recommended World Health Organization for use in children 5-36 month...
Clinical Trial
Frontiers in immunology. 2025 Jun 26:16:1620366. DOI:10.3389/fimmu.2025.1620366 2025
Yueyuan Hu,Hugo Cruz,Samikshya Santosh Nirmala et al.
Yueyuan Hu et al.
Regulatory T cells (Tregs) play a pivotal role in modulating excessive immune responses and maintaining immune homeostasis in humans. Notably, therapeutic strategies employing autologous and allogeneic Tregs have shown promising signs of ef...
Multi-omics reveals EGCG's anti-calcification effects associated with gut microbiota and metabolite remodeling [0.03%]
多组学揭示EGCG与肠道菌群和代谢产物重塑相关的抗钙化效应
Yating Zhang,Zihan Tang,Junwen Zhu et al.
Yating Zhang et al.
Introduction: Vascular calcification, a pathological process driven by heterotopic calcium-phosphate deposition, arises from vascular smooth muscle cells (VSMCs) osteochondrogenic transformation, epigenetic dysregulation,...
Revealing the significance of tissue-resident memory T cells in lung adenocarcinoma through bioinformatic analysis and experimental validation [0.03%]
通过生物信息学分析和实验验证揭示组织驻留记忆T细胞在肺腺癌中的意义
Zhuoqi Li,Mei Tian,Yuanhui Yang et al.
Zhuoqi Li et al.
Purpose: To investigate the functions of lung TRM cells in the development and treatment of lung adenocarcinoma (LUAD). Methods: R-lang...
EV-A71 invades the central nervous system and affects the blood-brain barrier in a tree shrew model [0.03%]
EV-A71侵入树鼩中枢神经系统并影响血脑屏障功能
Wen-Guang Wang,Xuan Wang,Na Li et al.
Wen-Guang Wang et al.
Introduction: The enterovirus A71 (EV-A71)-caused central nerve system (CNS) damage seriously endangers the health of infants and young children, but the underlying mechanisms by which EV-A71 crosses the blood-brain barri...
Machine learning-based integration of DCE-MRI radiomics for STAT3 expression prediction and survival stratification in breast cancer [0.03%]
基于机器学习的DCE-MRI影像组学在乳腺癌STAT3表达预测及预后分层中的应用
Dong Pan,Cheng-Yan Zhang,Ya-Fei Wang et al.
Dong Pan et al.
Objective: To explore the association between signal transducer and activator of transcription 3 (STAT3) expression, tumor immune microenvironment, and overall survival (OS) in breast cancer, and to develop a non-invasive...
Changing landscape of first-line treatment for locally advanced or metastatic urothelial carcinoma: the progression from platinum-based chemotherapy to platinum-free therapy [0.03%]
晚期或转移性尿路上皮癌一线治疗格局的演变：从以铂类化疗为基础到无铂类药物疗法
Zengguang Liu,Chen Chen,Jiaxin Yin et al.
Zengguang Liu et al.
Urothelial carcinoma (UC) represents the most common pathological type of bladder cancer. For patients with locally advanced or metastatic UC (la/m UC), the standard of care with platinum-based chemotherapy as the cornerstone has greatly im...