Optimized multiplex PCR-NGS for comprehensive HLA genotyping in Chinese populations: resolving ambiguities at high resolution [0.03%]
优化的多重PCR-NBS方法可对中国人群进行高分辨率HLA基因分型以解决低分辨分型的不确定性问题
Cuello Garcia Haider,Binbin Sun,Yinfeng Wang et al.
Cuello Garcia Haider et al.
Introduction: Accurate human leukocyte antigen (HLA) genotyping is critical for organ transplantation to ensure donor-recipient compatibility. Conventional methods, such as sequence-based typing (SBT), often face challeng...
Durable immunotherapeutic response in molecularly complex pulmonary adenosquamous carcinoma: case report and literature review [0.03%]
分子复杂型肺腺鳞癌免疫治疗长期有效的病例报告及文献回顾
Jun Zhu,Xin Xun,Jiayun Liu et al.
Jun Zhu et al.
Pulmonary adenosquamous carcinoma (ASC) is a rare and aggressive subtype of non-small cell lung cancer (NSCLC) with poorly defined molecular characteristics and therapeutic strategies. We present a 63-year-old male patient with stage IVa (c...
Enhancing fibroblast-epithelial cell communications: Serpine2 as a key molecule in Fusobacterium nucleatum-promoted colon cancer [0.03%]
增强成纤维细胞-上皮细胞通讯：Fusobacterium nucleatum促结肠癌中的关键分子Serpine2
Xueke Li,Simin Luo,Yifang Jiang et al.
Xueke Li et al.
Background: Fusobacterium nucleatum (Fn) has been identified as a causative factor in the progression of colon cancer. This study aims to integrate bulk RNA-seq with single-cell RNA-seq (scRNA-seq) to elucidate the molecu...
Latest advances and prospects in the pathogenesis, animal models, and vaccine research of severe fever with thrombocytopenia syndrome virus [0.03%]
发热伴血小板减少综合征病毒发病机制、动物模型及疫苗研究进展与展望
Chenghao Chen,Jiaxuan Li,Yumo Zhou et al.
Chenghao Chen et al.
Severe Fever with Thrombocytopenia Syndrome Virus (SFTSV), a tick-borne phlebovirus first identified in China, causes severe illness characterized by high fever, thrombocytopenia, leukopenia, and, in some cases, multi-organ failure and deat...
Case Report: dose adjustment of orelabrutinib for managing central nervous system post-transplant lymphoproliferative disorder following acute lymphoblastic leukemia transplantation [0.03%]
病例报告：调整奥雷布鲁替尼剂量以治疗急性淋巴细胞白血病移植后的中枢神经系统移植物抗宿主病及相关post-移植淋巴增值性疾病
Wenwen Wang,Jianlin Chen,Lingsu Guan
Wenwen Wang
We report a case of acute B-cell leukemia complicated by central nervous system (CNS) post-transplant lymphoproliferative disorder (PTLD) following allogeneic hematopoietic stem cell transplantation (allo-HSCT). The patient achieved sustain...
Efficacy and safety of ruxolitinib in adult patients with refractory rheumatic disease-associated macrophage activation syndrome [0.03%]
鲁索利替尼治疗难治性风湿病相关巨噬细胞活化综合征成人患者的疗效和安全性
Jingjing Li,Ran Wang,Jie Chen et al.
Jingjing Li et al.
Objective: Rheumatic disease-associated macrophage activation syndrome (RD-MAS) is a rare and life-threatening complication of rheumatic diseases, with approximately 30% of cases being refractory to conventional therapeut...
Integrated analysis of single-cell RNA-seq and spatial transcriptomics to identify the lactylation-related protein TUBB2A as a potential biomarker for glioblastoma in cancer cells by machine learning [0.03%]
结合单细胞RNA测序和空间转录组学的综合分析，利用机器学习在癌症细胞中鉴定乳酰化相关蛋白TUBB2A作为胶质母细胞瘤潜在生物标志物
Yifan Xu,Chonghui Zhang,Jinpeng Wu et al.
Yifan Xu et al.
Background: An increasing number of studies have revealed a link between lactylation and tumor initiation and progression. However, the specific impact of lactylation on inter-patient heterogeneity and recurrence in gliob...
Liquid-liquid phase separation: an emerging perspective on the tumorigenesis, progression, and treatment of tumors [0.03%]
液-液相分离：肿瘤发生、进展与治疗的新视角
Qin Jian,Qi Xu,Sirui Xiang et al.
Qin Jian et al.
Research in the field of Liquid-liquid phase separation (LLPS) breaks through the classical theory of gene mutation in the mechanism of tumorigenesis and provides a new perspective for comprehending tumors from a network regulation standpoi...
FTO O-GlcNAcylation promotes TRIM21-mediated FTO ubiquitination degradation to sustain the negative feedback control of macrophage inflammation [0.03%]
FTO O-GlcNAc酰化促进TRIM21介导的FTO泛素化降解以维持负反馈调控巨噬细胞炎症反应
Lu Zhang,Min Liu,Yan Xie et al.
Lu Zhang et al.
Introduction: The fat mass and obesity-associated protein (FTO), a key RNA N6-methyladenosine (m6A) demethylase, has been highlighted for its important role in inflammatory response. Emerging evidences link the O-GlcNAcyl...
The influence of H. pylori infection in HER2-positive gastric cancer cell lines: insights from Wnt/β-catenin pathway [0.03%]
幽门螺旋杆菌感染对HER2阳性胃癌细胞系的影响：Wnt/β-连环蛋白信号通路的启示
Valli De Re,Mariateresa Casarotto,Giulia Brisotto et al.
Valli De Re et al.
Introduction: The impact of H. pylori infection on the efficacy of trastuzumab in HER2-positive gastric cancer (GC) remains poorly understood, despite growing evidence that tumor microenvironment and host-pathogen interac...