Predicting immune-related adverse events in patients with melanoma: the role of interleukin-7 rs16906115 polymorphism and lymphocyte dynamics [0.03%]
预测黑色素瘤患者免疫相关不良事件：白细胞介素-7rs16906115多态性和淋巴细胞动态的的作用
Fatma Pınar Açar,Caner Acar,Damla Gunenc et al.
Fatma Pınar Açar et al.
Introduction: Immune checkpoint inhibitors (ICIs) have transformed the therapeutic landscape of malignant melanoma; however, they are frequently associated with immune-related adverse events (irAEs). Emerging evidence sug...
Case Report: Can early full-course tocilizumab therapy reverse vascular stenosis in Takayasu arteritis? [0.03%]
病例报告：托珠单抗全程治疗能否逆转泰亚塞斯基动脉炎患者的血管狭窄？
Congqi Hu,Lingjie Liu,Hui Xiao et al.
Congqi Hu et al.
Takayasu arteritis (TAK) is an idiopathic systemic disease characterized by granulomatous inflammation of the aorta and its branches. TAK can cause multiple vascular injuries throughout the body, mainly arterial stenosis and aneurysms. In s...
The OT-II model reveals dual in vitro and in vivo immunomodulatory properties of CD6 in T cell activation [0.03%]
OT-II模型揭示CD6在体内外T细胞活化中的双重免疫调节作用
Alejandra Leyton-Pereira,Irene Fernández-Delgado,María José Rodríguez-Lagunas et al.
Alejandra Leyton-Pereira et al.
Introduction: CD6 is a signal transducing transmembrane glycoprotein expressed on T-cells and a subset of B and NK cells that has emerged as a promising therapeutic target in autoimmunity and cancer.The extracellular doma...
Kangbo Wang,Yumo Zhang,Zhibo Han et al.
Kangbo Wang et al.
Chimeric antigen receptor T cell (CAR-T) therapy has revolutionized cancer immunotherapy by overcoming intrinsic limitations in T cell activation, achieving remarkable success in treating relapsed or refractory hematologic malignancies in b...
Multi-omics analysis reveals the role of ribosome biogenesis in malignant clear cell renal cell carcinoma and the development of a machine learning-based prognostic model [0.03%]
多组学分析揭示了核糖体生物发生在家兔恶性透明细胞肾癌中的作用及基于机器学习的预后模型的发展
Zhouzhou Xie,Shansen Peng,Jiongming Wang et al.
Zhouzhou Xie et al.
Background: Clear cell renal cell carcinoma (ccRCC) is the most common subtype of renal cancer, marked by high molecular heterogeneity and limited responsiveness to targeted or immune therapies. Ribosome biogenesis (Ribos...
Network pharmacology and UHPLC-HRMS reveal the mechanism of QSFZYL and BMSCs overexpressing IFN-γ against lung adenocarcinoma [0.03%]
基于网络药理学和超高分辨率质谱的千圣复元颗粒联合干扰素基因过度表达间充质干细胞对肺腺癌的作用机制研究
Zhen Lv,MingXuan Liu,YingYing Yang et al.
Zhen Lv et al.
Background: Lung cancer is a significant public health concern in China, posing a serious threat to the population. The QiShenFuZhengYiLiu (QSFZYL) is commonly prescribed as a complementary treatment for cancer patients, ...
IL-36/IL-36R signaling promotes CD4+ T cell-dependent colitis via pro-inflammatory cytokine production [0.03%]
白介素36/白介素36受体信号通过促炎症细胞因子产生促进CD4⁺T细胞依赖性结肠炎
Maya Maarouf,Michal Kuczma,Timothy L Denning
Maya Maarouf
Background: Inflammatory bowel disease (IBD) is a multifactorial, chronic disease that affects approximately 1.5 million people in the United States. Several important factors are implicated in the pathogenesis of IBD, on...
Mehmet Yabas,Carla M Roots,T Daniel Andrews et al.
Mehmet Yabas et al.
Fucosylation, a type of glycosylation, is the attachment of a fucose to N-glycans, O-glycans and glycolipids, and is critical for the post-translational regulation of many essential pathways. Here we describe a mouse strain with an N-ethyl-...
Gut microbiota-driven neuroinflammation in Alzheimer's disease: from mechanisms to therapeutic opportunities [0.03%]
阿尔茨海默病中由肠道微生物驱动的神经炎症：从机制到治疗机会
Wenhui Lei,Yiwen Cheng,Xia Liu et al.
Wenhui Lei et al.
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by amyloid-beta (Aβ) plaques, tau hyperphosphorylation, and chronic neuroinflammation. While neuroinflammation-mediated by microglial and astrocyte activati...
Sexual dimorphism-driven differences are overcome in a preclinical vaccine model against Trypanosoma cruzi [0.03%]
性别二态性驱动的差异在克鲁兹锥虫疫苗模型中被克服
Camila Bulfoni Balbi,Maria Florencia Pacini,Brenda Dinatale et al.
Camila Bulfoni Balbi et al.
Currently, no vaccine is available to prevent Chagas disease. Experimental vaccines against Trypanosoma cruzi (Tc) have shown high protection, but their development for humans still requires further study. Additionally, the sexual dimorphis...