From calcium pump to metabolic hub: emerging genetic phenotypes and metabolic networks of SERCA2 in skeletal muscle [0.03%]
从钙泵到代谢中心：SERCA2在骨骼肌中的新兴遗传表型和代谢网络
Shunyi Lei,Yanlong Qu,Jin Yan et al.
Shunyi Lei et al.
For decades, the sarco/endoplasmic reticulum Ca2+ ATPase 2 (SERCA2) in skeletal muscle was primarily recognized for its role in orchestrating slow-twitch muscle fiber relaxation-an essential process dependent on its ability to actively sequ...
Redox signaling in chronic airway diseases: pathogenic mechanisms and therapeutic implications [0.03%]
慢性气道疾病中的氧化还原信号：发病机制及治疗意义
Mario Cazzola,Paola Rogliani,Luigino Calzetta et al.
Mario Cazzola et al.
Chronic airway diseases, including asthma, chronic obstructive pulmonary disease (COPD), and bronchiectasis, impose a significant global health burden. A central unifying feature of these diseases is redox imbalance, which is characterized ...
Epigenetic reprogramming in metabolic dysfunction-associated steatotic liver disease: from metabolic memory to precision medicine [0.03%]
表观遗传重编程在代谢功能异常相关脂肪性肝病中的作用：从代谢记忆精准医疗
Basile Njei,Yazan A Al-Ajlouni
Basile Njei
Background: Metabolic dysfunction associated steatotic liver disease (MASLD) is the most common chronic liver disease worldwide and is characterized by substantial heterogeneity in clinical presentation, disease progressi...
Airway mucus in infection [0.03%]
感染性气道黏液异常
Caitlin Costello,Susan Birket
Caitlin Costello
The mucosa of the airways is under a near-constant barrage of contaminants, allergens, and pathogens that can accumulate and cause irritation or infection if not promptly removed. Mucus, composed of a mucin glycoprotein mesh, protects the a...
Swasti Rastogi,Amanda A de Oliviera,Yingnan Zhai et al.
Swasti Rastogi et al.
Background: Individuals with type 1 diabetes (T1D) exhibit elevated arterial stiffness and are at a higher risk of developing cardiovascular disease, both of which are sex dependent. However, whether sex differentially af...
Imaging photoplethysmography reveals differences in the reactions of cerebral and systemic hemodynamics to infusion of vasoactive drugs [0.03%]
imaging photoplethysmography显示脑循环和系统循环对血管活性药物的不同反应
Alexey Y Sokolov,Valeriy V Zaytsev,Anton V Shcherbinin et al.
Alexey Y Sokolov et al.
Introduction: According to the recent data, imaging photoplethysmography has extensive capabilities in clinical and experimental biomedical research. However, relationship between local vasomotor reactions, estimated as f...
Impact of arm position and load on upper and lower esophageal sphincter pressures [0.03%]
手臂位置和负荷对上下食管括约肌压力的影响
Petr Bitnar,Adam Kurka,Andrew Busch et al.
Petr Bitnar et al.
Background: The diaphragm contributes to respiration, postural stabilization, and regulation of esophageal sphincter pressures through its crural portion. Although its dual respiratory-postural role is established, the ef...
Cross-bridge model-based quantification of muscle metabolite alterations leading to fatigue during all-out knee extension exercise [0.03%]
基于横桥模型量化极限膝关节伸展运动中导致疲劳的肌肉代谢变化
John I Hendry,Muhammet Enes Erol,Gwenael Layec et al.
John I Hendry et al.
Intense physical exercise is associated with high energy demands and muscle metabolite changes that affect force generation, leading to muscle fatigue. Although these changes are well characterized in humans, their contribution to muscle fa...
Effects of different training on lower limb explosive power in youth soccer players: a systematic review and network meta-analysis [0.03%]
不同训练方式对青年足球运动员下肢爆发力影响的系统综述和网络Meta分析
HuaiBin Tan,ZhiGao Yan,Cong Shao et al.
HuaiBin Tan et al.
Background: Football demands high lower-limb explosive power for sprinting and jumping. Traditional youth training often emphasizes aerobic endurance and heavy resistance training, which may not optimally develop such pow...
Short-term cigarette smoke exposure aggravates oxidative stress and airway inflammation induced by lipopolysaccharides [0.03%]
短期吸入香烟烟雾加剧脂多糖诱导的氧化应激和气道炎症反应
Ziyao Liang,Zhihang Liu,Wenchao Pan et al.
Ziyao Liang et al.
Aim: This study discloses the early synergistic effects of short-term cigarette smoke (CS) exposure combined with lipopolysaccharide (LPS) on pulmonary inflammation and tissue stress. ...