Cardiac fibroblast heterogeneity in cardiac fibrosis implication for cell-type-specific treatment [0.03%]
心脏纤维化中心脏成纤维细胞异质性及其对特定类型细胞治疗的启示
Kai Gu,Dongyan Song,Jisheng Chen
Kai Gu
Cardiac fibrosis is a central feature of heart disease, driven by excessive extracellular matrix (ECM) accumulation and associated with mechanical stiffening, electrical instability, and heart failure. While cardiac fibroblasts (CFs) were h...
The attenuated incretin effect is associated with glucose intolerance in patients with hepatitis B-related acute-on-chronic liver failure [0.03%]
乙型肝炎相关急性-on-慢性肝功能衰竭患者葡萄糖耐量受损与肠促胰素效应减弱有关
Meichuan Li,Han Hu,Yujuan Liu et al.
Meichuan Li et al.
Objective: The pathogenesis of glucose homeostasis disturbance in acute-on-chronic liver failure (ACLF) remains poorly defined. This study aimed to investigate the association between incretin effect (IE) and glucose into...
Reduced task-related quadriceps sEMG and limited functional transfer after 4-week low-load blood flow restriction training: a pilot randomized controlled study [0.03%]
4周低负荷血液流阻断训练后的任务相关股四头肌肌肉减少和功能转化受限：一项随机对照试验试点研究
Junwei Xia,Wonil Son,Tianqi Zhao et al.
Junwei Xia et al.
Background: Low-load blood-flow restriction training (BFR-LIR) can enhance strength-related adaptations with reduced mechanical stress, but whether it promotes task-related neuromuscular economy (lower task-related sEMG a...
From mechanical force to cellular response: the role of autophagy in orthodontic tooth movement [0.03%]
从机械力到细胞反应：自噬在牙齿矫形移动中的作用
Yuan Dong,Yangyu Liu,Zhiqiang Hu et al.
Yuan Dong et al.
Orthodontic tooth movement (OTM) is a process responding to orthodontic forces, which converts mechanical stresses into biochemical events to reconstruct the periodontal ligament and alveolar bone. As a lysosome-dependent catabolic process ...
Artificial intelligence-driven gastrointestinal functional assessment: multimodal imaging, digital biomarkers, and real-time monitoring [0.03%]
基于人工智能的胃肠功能评估：多模态成像、数字生物标志物和实时监测
Liucheng Li,Fang Lv,Chen Du et al.
Liucheng Li et al.
Gastrointestinal (GI) functional disorders and chronic inflammatory diseases impose a substantial health burden, yet their assessment remains challenging because symptoms reflect dynamic interactions among motility, visceral sensation, immu...
The threat of pollutants mixtures on freshwater fishes in Sri Lankan lotic ecosystems under changing climate: a review of current status and future research perspective [0.03%]
斯里兰卡流水生境下污染物混合物对淡水鱼威胁的气候变动性：现状及未来研究展望综述分析
W A A N Wickramasinghe,K M S Ruvinda
W A A N Wickramasinghe
Multiple point and nonpoint sources add complex mixtures of pollutants that may pose detrimental impacts on freshwater fish. These pollutants include metallic and nonmetallic inorganic ions and an array of organic compounds. Climate-related...
Positive end-expiratory pressure increases intracranial pressure but does not affect PRx, regardless of body position, in a porcine ARDS model [0.03%]
呼气末正压可升高颅内压但不影响混合静脉血氧饱和度，与体位无关——一项猪ARDS模型研究
Rønnaug Hammervold,Erta Beqiri,Peter Smielewski et al.
Rønnaug Hammervold et al.
Background: Positive end-expiratory pressure (PEEP) and prone positioning are key components in the management of acute respiratory distress syndrome (ARDS), improving gas exchange and protecting the lung via enhanced lun...
Effects of six different exercise therapies on sleep indices, cardiopulmonary endurance, and body composition in patients with sleep-related breathing disorders: network meta-analysis of 40 RCTs [0.03%]
六种不同运动疗法对睡眠呼吸障碍患者睡眠质量、心肺耐力及体成分的影响：40项随机对照试验的网络meta分析
Zhenhao Ma,Qinghui Li
Zhenhao Ma
Background: Sleep apnea syndrome is a common sleep disorder that frequently leads to multi-systemic damage. Traditional therapies have limitations, while exercise interventions show potential; however, the efficacy of dif...
Acetate and combinations of short-chain fatty acids increase oxidative phenotype and contribute to muscle fiber type shift in myotubes [0.03%]
乙酸和短链脂肪酸组合通过提高氧化表型促进肌管中的肌纤维类型转换
Britt M J Otten,Mireille M J P E Sthijns,Harry R Gosker et al.
Britt M J Otten et al.
Introduction: Intestinal microbial fermentation produces short-chain fatty acids (SCFAs) that signal from the large intestine to skeletal muscle. Skeletal muscle exhibits phenotypic plasticity, with fiber-type composition...
Dance versus other exercise modalities in mild cognitive impairment and dementia: comparative efficacy from a systematic review and bayesian network meta-analysis [0.03%]
舞蹈与其他运动模式在轻度认知障碍和痴呆中的效果比较：系统评价和贝叶斯网状meta分析的疗效综合结果
Ye Zhao,Dan Tao,Bian Zhao et al.
Ye Zhao et al.
Background: Dance is a non-pharmacological option for people with cognitive impairment, yet its comparative advantage over other exercise modalities is still uncertain. This study compared and ranked dance versus other ex...