Heterozygous Deletion of Epilepsy Gene KCNQ2 Has Negligible Effects on Learning and Memory [0.03%]
epilepsy基因KCNQ2杂合缺失对学习记忆影响甚微
Gregory C Tracy,Angelina R Wilton,Justin S Rhodes et al.
Gregory C Tracy et al.
Neuronal Kv7/Potassium Voltage-Gated Channel Subfamily Q (KCNQ) potassium channels underlie M-current that potently suppresses repetitive and burst firing of action potentials (APs). They are mostly heterotetramers of Kv7.2 and Kv7.3 subuni...
Editorial: Animal Models of Anxiety and Depression: Exploring the Underlying Mechanisms of Sex Differences [0.03%]
编者按：焦虑和抑郁的动物模型：探索性别差异的潜在机制
Laura B Tucker,Mario G Oyola,Deborah Suchecki et al.
Laura B Tucker et al.
Michael H Connors,Peter W Halligan
Michael H Connors
Trait Anxiety Does Not Predict the Anxiogenic Response to Sleep Deprivation [0.03%]
特质焦虑不能预测睡眠剥夺的焦虑反应
Tina Sundelin,Benjamin C Holding
Tina Sundelin
Sleep deprivation has in several studies been found to increase anxiety. However, the extent to which this anxiogenic effect depends on one's underlying trait anxiety has not previously been determined. Using two separate sleep-loss experim...
Assessment of Binge-Like Eating of Unsweetened vs. Sweetened Chow Pellets in BALB/c Substrains [0.03%]
BALB/c不同亚系小鼠对未加糖和加糖颗粒饲料的暴食行为评估
Katherine D Sena,Jacob A Beierle,Kayla T Richardson et al.
Katherine D Sena et al.
Binge eating disorder (BED) is defined as chronic episodes of consuming large amounts of food in less than 2 h. Binge eating disorder poses a serious public health problem, as it increases the risk of obesity, type II diabetes, and heart di...
Environmental Enrichment Reverses Maternal Sleep Deprivation-Induced Anxiety-Like Behavior and Cognitive Impairment in CD-1 Mice [0.03%]
环境丰富可逆转母鼠睡眠剥夺引起的CD-1小鼠类似焦虑的行为和认知障碍
Yue-Ming Zhang,Yun-Zhou Cheng,Ya-Tao Wang et al.
Yue-Ming Zhang et al.
Preclinical studies have clearly indicated that offspring of mothers who suffered sleep deprivation during pregnancy exhibit anxiety, depression-like behaviors, and cognitive deficits. The cognitive impairment induced by maternal sleep depr...
Thomas Doublet,Mona Nosrati,Clifford G Kentros
Thomas Doublet
Interactions between conspecifics are central to the acquisition of useful memories in the real world. Observational learning, i.e., learning a task by observing the success or failure of others, has been reported in many species, including...
Ultrasonic Vocalizations in Adult C57BL/6J Mice: The Role of Sex Differences and Repeated Testing [0.03%]
成年C57BL/6J小鼠超声波发声的性别差异及重复测试的作用
Marika Premoli,Valeria Petroni,Ronald Bulthuis et al.
Marika Premoli et al.
Ultrasonic vocalizations (USVs) are a major tool for assessing social communication in laboratory mice during their entire lifespan. At adulthood, male mice preferentially emit USVs toward a female conspecific, while females mostly produce ...
Maximilian Harkotte,María P Contreras,Marion Inostroza et al.
Maximilian Harkotte et al.
The formation of semantic memories is assumed to result from the abstraction of general, schema-like knowledge across multiple experiences, while at the same time, episodic details from individual experiences are forgotten. Against this bac...
Dopamine Transporter Knockout Rats Show Impaired Wellbeing in a Multimodal Severity Assessment Approach [0.03%]
多巴胺转运体敲除大鼠的多模式严重度评估方法显示其福祉受损
Anne Stephanie Mallien,Laura Becker,Natascha Pfeiffer et al.
Anne Stephanie Mallien et al.
In preclinical psychiatry research, animals are central to modeling and understanding biological mechanisms of behavior and psychiatric disorders. We here present the first multimodal severity assessment of a genetically modified rat strain...