Chronic Ethanol Causes Persistent Increases in Alzheimer's Tau Pathology in Female 3xTg-AD Mice: A Potential Role for Lysosomal Impairment [0.03%]
慢性乙醇导致APP/PS1转基因雌鼠tau蛋白持续性增加及溶酶体损伤
Autumn E Tucker,Coral Del Mar Alicea Pauneto,Alexandra M Barnett et al.
Autumn E Tucker et al.
Epidemiological studies have found that heavy alcohol use is associated with increased risk for Alzheimer's disease (AD), with frequent drinking earlier in adulthood increasing risk. The increases in neuroinflammation featured in both heavy...
Corticosterone Levels and Glucocorticoid Receptor Gene Expression in High Drinking in the Dark Mice and Their Heterogeneous Stock (HS/NPT) Founder Line [0.03%]
酒精诱导的应激反应相关激素皮质酮水平和糖皮质激素受体基因在高饮酒的遗传品系及其祖系的表达差异研究
Antonia M Savarese,Kolter B Grigsby,Bryan E Jensen et al.
Antonia M Savarese et al.
The High Drinking in the Dark (HDID-1) line of mice has been selectively bred for achieving high blood alcohol levels (BALs) in the Drinking in the Dark task, a model of binge-like drinking. Recently, we determined that glucocorticoid recep...
Jing Wang,Haoyu Huang,Chunming Liu et al.
Jing Wang et al.
Autism spectrum disorder (ASD) is a neurodevelopmental disorder that can lead to severe social behavioral difficulties, which mainly manifests as social communication and interaction disorders; narrow interests; and repetitive, stereotyped ...
Marco Bortolato,Gregory J Madden
Marco Bortolato
Activation of Estrogen Receptor β in the Lateral Habenula Improves Ovariectomy-Induced Anxiety-Like Behavior in Rats [0.03%]
通过激活垂体上核雌激素受体β改善卵巢切除大鼠的焦虑样行为
Xiaofeng Liu,Meiying Song,Xiaowei Chen et al.
Xiaofeng Liu et al.
Background: Loss of estrogen due to menopause or ovarian resection is involved in the development of anxiety, which negatively impacts work productivity and quality of life. Estrogen modulates mood by binding to estrogen ...
Abnormal Visual Evoked Responses to Emotional Cues Correspond to Diagnosis and Disease Severity in Fibromyalgia [0.03%]
纤维肌痛诊断和疾病严重程度与情绪诱导的视觉诱发反应异常相关性研究
Noam Goldway,Nathan M Petro,Jacob Ablin et al.
Noam Goldway et al.
Background: Chronic pain disorders are often associated with cognitive-emotional dysregulation. However, the relations between such dysregulation, underlying brain processes, and clinical symptom constellations, remain un...
A New Vestibular Stimulation Mode for Motion Sickness With Emphatic Analysis of Pica [0.03%]
一种新的前庭刺激模式及其对运动病的自主神经研究
Zhi-Hao Zhang,Li-Peng Liu,Yan Fang et al.
Zhi-Hao Zhang et al.
Motion sickness (MS) was frequently introduced for rodents in research work through passive motion that disturbed vestibular signals in the presence of visual and aleatory, proprioceptive inputs. Inducement of MS in this way causes conflict...
Pomegranate and Its Components, Punicalagin and Ellagic Acid, Promote Antidepressant, Antioxidant, and Free Radical-Scavenging Activity in Ovariectomized Rats [0.03%]
促进卵形切除大鼠抗抑郁，抗氧化和自由基清除活性的石榴及其成分原花青素和鞣酸
Nancy Cervantes-Anaya,Gabriel Azpilcueta-Morales,Erika Estrada-Camarena et al.
Nancy Cervantes-Anaya et al.
Previous reports described the antidepressant-like action of the aqueous extract of pomegranate (Punica granatum: AEPG). Thus we evaluated the effect of AEPG and the main compounds found in the extract, punicalagin (PNCG) and ellagic acid (...
Neural Markers of Methylphenidate Response in Children With Attention Deficit Hyperactivity Disorder [0.03%]
注意缺陷多动障碍儿童对甲基苯丙胺的神经反应标志物研究
Anne B Arnett,Tara M Rutter,Mark A Stein
Anne B Arnett
Background: Despite widespread use of stimulants to treat ADHD, individual responses vary considerably and few predictors of response have been identified. The identification of reliable and clinically feasible biomarkers...