Priming neuronal regeneration: early adaptive mechanisms in zebrafish CNS injury [0.03%]
神经再生的启动：斑马鱼中枢神经系统损伤后的早期适应机制
Ignacio Babiloni Chust,Lucia Poggi,Michela Alessandra Denti et al.
Ignacio Babiloni Chust et al.
The zebrafish (Danio rerio) exhibits a remarkable capacity to regenerate the central nervous system following injury, restoring both tissue architecture and neural function. This review focuses on the earliest phases of the injury response,...
Integrated multi-omics profiling reveals novel molecular biomarkers and pathways associated with Fragile X-associated tremor/ataxia syndrome [0.03%]
整合多组学分析揭示与脆性X染色体综合征相关的新型分子生物标志物和信号通路
Marwa Zafarullah,Matthew Ponzini,Kyoungmi Kim et al.
Marwa Zafarullah et al.
Introduction: Fragile X-associated tremor/ataxia syndrome (FXTAS) is a late-onset neurodegenerative disorder affecting carriers of premutation expansions (55-200 CGG repeats) in the fragile X messenger ribonucleoprotein 1...
CaMPARI2 enables stimulus-locked whole-brain activity mapping at cellular resolution in unrestrained larval zebrafish [0.03%]
CaMPARI2可在未受束缚的斑马鱼幼虫中实现刺激锁定的全脑细胞分辨率活动图谱绘制
Kate R Robbins,Amelia Bredbenner,Rebecca A Osbaldeston et al.
Kate R Robbins et al.
Visualizing active neurons and circuits in vivo is critical for investigating the neural activity that underlies behavior. While several established methodologies are available to achieve this end in larval zebrafish, they are limited by th...
Exploring the molecular mechanism of dexmedetomidine in alleviating blood-brain barrier disruption in rats with cerebral ischemia reperfusion injury based on network pharmacology [0.03%]
基于网络药理学探讨右美托咪啶改善脑缺血再灌注损伤大鼠血脑屏障破坏的分子机制研究
Xue Lv,Wei Gao,Zhi-Guo Zhang et al.
Xue Lv et al.
Objective: This study aimed to clarify the neuroprotective effect of dexmedetomidine (DEX) against cerebral ischemia reperfusion injury (CIRI) and its underlying mechanism using network pharmacology and in vivo validation...
From metabolic substrate to epigenetic regulation: roles and mechanisms of lactylation in brain health and disease [0.03%]
从代谢底物到表观遗传调控：乳酰化在脑健康和疾病中的作用及机制
Wei Chen,Ruobing Li,Jinlong Zhang et al.
Wei Chen et al.
Lactate, traditionally regarded as a metabolic byproduct of glycolysis, is now recognized as a critical signaling molecule in the central nervous system. Emerging evidence indicates that lactate participates in a dynamic metabolic-epigeneti...
Exploring the mechanism of Yin Huo decoction in PCPA-induced depression mice: a metabolomics and network pharmacology approach [0.03%]
基于代谢组学和网络药理学探讨阴虚火旺证郁模型小鼠机制研究及阴斛解郁颗粒干预效应
Yu Zhou,Lu Jia Liu,Yue Zhang et al.
Yu Zhou et al.
Introduction: Depression is a prevalent neuropsychiatric disorder, and traditional Chinese medicine formulations such as Yin Huo Decoction (YHD) have shown potential antidepressant effects, yet their underlying mechanisms...
Abnormal lymphatic system function in patients with chronic neck and shoulder pain: neuroimaging evidence from DTI-ALPS [0.03%]
慢性颈肩痛患者淋巴系统功能异常：DTI-ALPS的神经影像证据
Jiayu Yang,Tianci Liu,Ruhui Xiao et al.
Jiayu Yang et al.
Objective: Chronic neck and shoulder pain (CNSP) is frequently associated with structural and functional brain damage that progressively worsens over time. The glymphatic system (GS), a gel-like extracellular fluid in the...
Integrative genomic analysis identifies key target genes and candidate drugs for spinal stenosis [0.03%]
整合基因组分析确定脊柱狭窄的关键目标基因和候选药物
Demeng Xia,Yongjie Chen,Rui Wu et al.
Demeng Xia et al.
Background: Spinal stenosis is a common pathological condition characterized by the narrowing of the spinal canal, contributing to substantial morbidity and imposing a significant socioeconomic burden. Despite its clinica...
Chronic pain, fatigue, and emotional distress in female FMR1 premutation carriers [0.03%]
FMR1前突变女性携带者的慢性疼痛、疲劳和情绪困扰
Dragana Protic,Maja Stojkovic,Randi Hagerman et al.
Dragana Protic et al.
Introduction: Carriers of the FMR1 gene premutation (PM) are at increased risk for Fragile X-associated PM Conditions (FXPAC). Some clinically significant symptoms can be further classified as Fragile X-associated Neurops...
CNP-induced cGMP signaling reduces growth cone stiffness and Ca2+ levels in embryonic DRG neurons [0.03%]
CNP诱导的cGMP信号降低胚胎DRG神经元生长锥的刚度和Ca2+水平
Aylin Balmes,Hannes Schmidt,Stefanie Peters et al.
Aylin Balmes et al.
A cyclic guanosine monophosphate (cGMP) signaling pathway composed of the extracellular ligand C-type natriuretic peptide (CNP), the transmembrane natriuretic peptide receptor 2 (Npr2), and the cGMP-dependent protein kinase I (cGKI) regulat...