Caffeine attenuates cisplatin induced microglial reactivity and cognitive dysfunction [0.03%]
咖啡因能减轻顺铂诱导的小胶质细胞活化和认知障碍
Alfredo Oliveros,Ivan Loncar,Marwan Mostafa et al.
Alfredo Oliveros et al.
Advances in cancer treatment by chemotherapy, radiation, and personalized targeted therapy have significantly improved cancer survivorship. Life extension from chemotherapy is arguably the most accessible non-surgical treatment strategy, bu...
Application of auricular therapy in postherpetic neuralgia: a scoping review [0.03%]
耳穴疗法治疗带状疱疹后神经痛的应用进展：系统综述性文章
Xiaoyang Wang,Hejia Wan,Xiaohui Liu et al.
Xiaoyang Wang et al.
Objective: To conduct a scoping review on the application of auricular therapy in treating postherpetic neuralgia (PHN), comprehensively examining the current clinical status, efficacy, and potential mechanisms of differe...
Bridging the anatomical gap: evolutionary conservation of genetic mechanisms in corpus callosum disorders across human, mouse, and zebrafish [0.03%]
从人到小鼠再到斑马鱼：胼胝体疾病遗传机制的进化保守性研究
Ayushma,Priyanka Prakash Srivastava,Shilpi Minocha
Ayushma
The Corpus Callosum (CC) is the largest white matter structure in the placental mammalian brain, facilitating critical interhemispheric communication. Anomalies of the CC, ranging from complete agenesis (ACC) to hypoplasia and dysgenesis, a...
The dual role of endoplasmic reticulum stress in cerebral ischemia: from adaptive protection to apoptotic induction [0.03%]
内质网应激在脑缺血的双重作用：从适应性保护到诱导凋亡
Jiehong Wang,Ying Shen
Jiehong Wang
Endoplasmic reticulum (ER) stress is a critical determinant of neuronal fate following cerebral ischemia, functioning as both an adaptive survival mechanism and a potent inducer of cell death. Ischemic insult and subsequent reperfusion prof...
The H3K9me2-FOXG1-microRNA axis reduces cochlear hair cells damage by modulating autophagy in age-related hearing loss [0.03%]
H3K9me2-FOXG1-微小RNA轴通过调节自噬减少与年龄相关听力损失的耳蜗毛细胞损伤
Sihui Wen,Yongping Huang,Yurong Mu et al.
Sihui Wen et al.
Age-related hearing loss (ARHL) is a growing global health concern due to its irreversibility and multifactorial pathogenesis. Epigenetic alterations are emerging as key drivers of aging, yet the mechanisms underlying their contribution to ...
Opportunities and challenges in studying non-coding RNAs using neural organoid models [0.03%]
利用神经器官模型研究非编码RNA的机会与挑战
Po-Sung Chiang,Meng-Han Tsai,Pei-Shan Hou
Po-Sung Chiang
Recent advancements in whole-genome sequencing have identified non-coding RNAs (ncRNAs) as pivotal regulators in biological systems. However, investigating neural-related ncRNAs in vitro remains challenging due to their complex spatial expr...
Optimizing single-session CBT delivery in an 8-session longitudinal therapeutic assessment (FRAX-TA) for women with FMR1 Premutation [0.03%]
优化FMR1前突变女性纵向治疗评估（FRAX-TA）中单次会话CBT的交付效果（8次会话）
Federica Alice Maria Montanaro,Giuseppina Spano,Randi J Hagerman et al.
Federica Alice Maria Montanaro et al.
Background: Therapeutic Assessment (TA) is a client-centered approach that uses psychological evaluation to promote therapeutic change. While TA has shown benefits across populations, its application to genetically at-ris...
Ludmila Müller,Svetlana Di Benedetto,Viktor Müller
Ludmila Müller
Nutrition is increasingly recognized as a central determinant of brain health across the lifespan. Beyond their classical roles as energetic substrates, dietary components and their bioactive metabolites may act as signaling molecules capab...
LRRK2 regulates ArfGAP1 membrane localization, activity and neuronal integrity via phosphorylation within its lipid-sensing ALPS2 motif [0.03%]
LRRK2通过其脂质感应ALPS2基序中的磷酸化调控ArfGAP1的膜定位，活性和神经元完整性
Md Shariful Islam,Valentin Cóppola-Segovia,Alessandra Musso et al.
Md Shariful Islam et al.
Introduction: Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene cause late-onset, autosomal dominant Parkinson's disease (PD). LRRK2 encodes a multi-domain protein containing a Roc GTPase domain and a serine/thre...
Sphingomyelin synthase 1 as a potential upstream amplifier of microglial CSF1R signaling in neuropathic pain [0.03%]
鞘氨醇单磷酸脂合成酶1是神经病理性疼痛小胶质细胞CSF1R信号转导的上游放大因子
Minghui Tan,Meiping Wu,Meikui Wu
Minghui Tan
Neuropathic pain is a debilitating chronic condition sustained by maladaptive neuroimmune interactions within the central nervous system, with microglial activation in the spinal dorsal horn serving as a critical driver of pain initiation a...