Microbiota and mycobiota in chronic inflammatory demyelinating polyneuropathy: clinical and pathophysiological correlations [0.03%]
慢性炎症性脱髓鞘多发神经病的微生物群和真菌群：临床与病理生理相关性
Szymon Andrusiów,Anita Brzoza,Piotr Łacina et al.
Szymon Andrusiów et al.
Introduction: Chronic inflammatory demyelinating polyneuropathy (CIDP) is an immune mediated neuropathy with incompletely defined triggers and no validated biomarkers. We investigated associations between bacterial and fu...
Calcium signaling and postsynaptic density dynamics: the roles of calmodulin in synaptic protein regulation [0.03%]
钙信号与突触后致密物动力学：钙调素在突触蛋白质调节中的作用
Keyaa Dilip Shah,Yonghong Zhang
Keyaa Dilip Shah
Calcium signaling in neuronal cells is the principal mechanism underlying learning and synaptic plasticity, whereas the postsynaptic density (PSD) is an important center where calcium-dependent processes are organized and regulated. This re...
Decoding GPCR signaling in living cells to advance early therapeutic discovery for neurological disorders [0.03%]
解码GPCR信号转导促进神经疾病早期药物发现
Giulia Palladino,Rafael Patarra,Zhenke Li et al.
Giulia Palladino et al.
G protein-coupled receptors (GPCRs) are major drug targets for neurodegenerative, neurodevelopmental and psychiatric disorders and are targeted by a multitude of marketed drugs. Typically, multiple GPCRs are involved in diseases of this typ...
Qiang Gu,James Raymick,Sumit Sarkar et al.
Qiang Gu et al.
Studying the cerebrovasculature is crucial for both basic neuroscience and clinical medicine, as the brain's vascular network is dynamic and undergoes changes with aging and disease. In this study, we introduce a novel approach for visualiz...
Risperidone regulates the expression of schizophrenia-related genes in the forebrain of adult male mice [0.03%]
利培酮调节成年小鼠前脑精神分裂症相关基因的表达
Magdalena Ziemiańska,Mateusz Zięba,Anna Radlicka-Borysewska et al.
Magdalena Ziemiańska et al.
Introduction: Risperidone is a widely used antipsychotic that reduces psychotic symptoms through modulation of monoaminergic signaling. At the cellular level, however, its effects extend beyond receptor antagonism and ind...
Advances in pathogenesis, novel therapeutic strategies and interventions for age-related hearing loss [0.03%]
年龄相关性听力损失的发病机制、新型治疗策略及干预手段研究进展
Zhiyang Wen,Yinfei Liang,Dongxue Wu et al.
Zhiyang Wen et al.
Age-related hearing loss (ARHL), or presbycusis, represents one of the most prevalent sensory dysfunctions in the elderly people. It is characterized by progressive hearing deterioration that significantly impairs quality of life and increa...
The mechanism of dynamic switching between M1/M2 phenotypes of microglia in neuropathic pain: a narrative review [0.03%]
神经病理性疼痛下微胶质细胞M1/M2表型动态转换机制的叙事性综述
Yunyan Mao,Longsheng Xu,Ming Yao
Yunyan Mao
Neuropathic pain (NeP) is a chronic pain disorder caused by damage to the somatosensory system, often presenting with long-lasting symptoms and limited efficacy of standard pharmacological treatments. Recent evidence indicates that the micr...
Mass spectrometry-based proteomic profiling of human tauopathy brains suggests mitochondria-associated alterations [0.03%]
基于质量谱的人类tau蛋白病脑蛋白组学分析表明与线粒体相关的变化
Alfi Raudatil Jannah,Mai Hasegawa,Jonathan Ham et al.
Alfi Raudatil Jannah et al.
Tauopathies are neurodegenerative disorders characterized by intracellular accumulation of abnormal tau encoded by MAPT, yet their molecular mechanisms remain incompletely understood. We aimed to identify proteomic signatures associated wit...
Human iPSC-derived motor neurons as a platform for elucidating TDP-43-related amyotrophic lateral sclerosis pathogenesis: a mini review [0.03%]
人多能干细胞来源的运动神经元作为研究TDP-43相关渐冻症发病机制的平台：一综述
Satoshi Yokoi,Yohei Iguchi,Masahisa Katsuno
Satoshi Yokoi
TAR DNA-binding protein 43 (TDP-43) is a major pathogenic RNA-binding protein associated with amyotrophic lateral sclerosis (ALS). Heterozygous mutations in TDP-43 cause familial ALS, known as ALS10. TDP-43 is predominantly localized in the...
Spatiotemporal patterns of gene expression changes in the mouse dentate gyrus following entorhinal denervation [0.03%]
内侧内嗅皮层神经元缺失后小鼠齿状回基因表达时空变化模式分析
Jessica Schlaudraff,Domenico Del Turco,Jana Key et al.
Jessica Schlaudraff et al.
Introduction: The central nervous system responds to acute injury with plastic remodeling of its network. However, the temporal and structural dynamics of this response in the denervated dentate gyrus remain poorly unders...