Editorial: Emerging mechanisms in neurodegenerative disease pathogenesis: vertebrate and invertebrate model organisms [0.03%]
述评：神经退行性疾病发病机制中的新进展：脊椎动物和无脊椎动物模型
Sandra Almeida,Yuyu Song,Filipe Marques et al.
Sandra Almeida et al.
Extracellular vesicles as nanocarriers in glioblastoma: implications for chemoresistance and immune evasion [0.03%]
胶质母细胞瘤中外泌体作为纳米载体的意义：对化学抗性和免疫逃避的影响
Faezeh Ebrahimi,Taha Rahavi Ezabadi,Hale Asghari et al.
Faezeh Ebrahimi et al.
Glioblastoma (GBM), the most aggressive primary brain tumor, remains highly resistant to conventional therapies because of its pronounced intratumoral heterogeneity, adaptive plasticity, and complex tumor microenvironment. Increasing eviden...
Proline-directed phosphorylation and prolyl isomerization oppose each other to regulate PSD-95 ubiquitination and excitatory synaptic plasticity [0.03%]
脯氨酸定向磷酸化和脯氨酰异构化相互拮抗调节PSD-95泛素化及兴奋性突触可塑性
Prajwal Kurup,Abigail R Thielbar,Evan Jasinski et al.
Prajwal Kurup et al.
PSD-95 is a key scaffolding protein in excitatory synapses, playing a critical role in stabilizing synaptic receptors. Post-translational modifications such as phosphorylation and ubiquitination have been shown to regulate PSD-95's localiza...
Rui Yan,Guanghui Ma,Haixia Huang et al.
Rui Yan et al.
Sepsis-associated encephalopathy (SAE) is a diffuse brain dysfunction induced by sepsis, characterized by high mortality and frequent long-term cognitive impairment. Its pathogenesis involves multiple mechanisms, including endothelial activ...
Stress-related neuroplasticity and developmental vulnerability in functional neurological disorder: from adverse experience to maladaptive overlearning [0.03%]
与功能性神经障碍相关的压力诱导神经可塑性及发育脆弱性：从不良经历到适应不良的过度学习
Ioannis Mavroudis,Foivos Petridis,Alin Ciobica et al.
Ioannis Mavroudis et al.
Functional Neurological Disorder (FND) is increasingly understood as a disorder of brain functioning rather than structural damage. While contemporary predictive coding models have provided important insights into the generation of function...
The dual role of ATF4 in neurons: from stress adaptation to therapeutic intervention [0.03%]
ATF4在神经元中的双重作用：从压力适应到治疗干预
Hua Huang,Yao Xu,Xingyi Li et al.
Hua Huang et al.
Activating transcription factor 4 (ATF4) functions as the central transcriptional arbiter of the integrated stress response (ISR) in neurons. Its translation is gated by diverse upstream kinases via the eIF2α pathway, while its functional ...
Voluntary wheel exercise reduces pain behavior by modulating neuroinflammation in neuropathic pain [0.03%]
自愿跑步减少神经病理性疼痛的行为及调节神经炎症作用的研究
Yuqi Zhu,Wenyang Xu,Jinhui Zhang
Yuqi Zhu
Neuropathic pain (NP) is a common condition caused by injury or disease of the somatosensory nervous system. It is associated with excessive inflammation of the central and peripheral nervous system. The treatment of NP is extremely challen...
Molecular interplay between glycogen synthase kinase 3 beta and A-kinase anchoring protein 11 in bipolar disorder: a narrative review [0.03%]
双相情感障碍中糖原合成酶激酶3β与A激酶锚定蛋白11的相互作用：综述
A Ashvil,Prakash Patil,Shrinivasa Undaru Bhat et al.
A Ashvil et al.
Bipolar disorder (BD) is a complicated psychiatric condition which is determined by episodic mood instability, yet its underlying biological foundation still remains poorly understood. A-kinase anchoring protein 11(AKAP11) has been identifi...
Systemic TGF-β1 reduction contributes to neuronal GLUT4 trafficking impairment in acute hepatic encephalopathy [0.03%]
TGF-β1系统性降低导致急性肝性脑病神经元GLUT4易位障碍
M Popek,M Zielińska
M Popek
Acute liver failure disrupts cerebral glucose homeostasis and contributes to neurological manifestations of hepatic encephalopathy (HE). Neurons, which partly rely on the insulin-sensitive glucose transporter GLUT4, may be particularly vuln...
Glymphatic dysfunction and neuroinflammation in FXTAS: evidence from DTI-ALPS and gene expression analysis [0.03%]
脆性X染色体相关震颤/共济失调综合征中甘淋巴系统功能障碍和神经炎症：来自DTI-ALPS和基因表达分析的证据
Andrea Elias-Mas,Esther Granell Moreno,Cèlia Painous Martí et al.
Andrea Elias-Mas et al.
Background and objectives: Fragile X-associated tremor/ataxia syndrome (FXTAS) is a late-onset neurodegenerative disorder that affects carriers of the FMR1 premutation (55-200 CGG repeats). It is characterized by motor an...