Gene expression mapping of conserved GABAergic interneuron markers in developing zebrafish [0.03%]
发育中的斑马鱼中保守的GABA能中间神经元标记物的基因表达图谱
Bingyao Zhu,Scott C Baraban
Bingyao Zhu
γ-Aminobutyric acid (GABA)-expressing interneurons play a crucial role in regulating brain activity, and their impairment or loss is linked to various neurological disorders. While mammalian research establishes embryonic ganglionic eminen...
Endosomal MrGPRX1 signaling sensitizes TRPV1 to enhance itch [0.03%]
溶酶体MrGPRX1信号转导敏使TRPV1通道活化以增强痒觉感知
Paz Duran,Jeffri S Retamal,Marcella de Amorim Ferreira et al.
Paz Duran et al.
G protein-coupled receptors (GPCRs) and TRPV (transient receptor potential vanilloid) channels are crucial for signal transduction in physiological processes, including neurotransmission, pain, and itch. Downstream effectors of GPCR signali...
Marcella de A Ferreira,Raquel Tonello,Paz Duran et al.
Marcella de A Ferreira et al.
Introduction: Chronic itch is a major burden, impacting the quality of life for one in four adults, and is closely associated with increased levels of anxiety, depression, and suicide. Despite its widespread burden, the p...
The GR of CA1 is involved in anxiety-like behavior induced by 0.8/2.65 GHz dual-frequency electromagnetic radiation [0.03%]
CA1区GR参与0.8/2.65GHz双频电磁辐射诱导的焦虑样行为
Bin Sun,Teng Xue,Yani Liu et al.
Bin Sun et al.
Introduction: The proliferation of wireless communication has increased environmental exposure to complex radiofrequency electromagnetic radiation (EMR), sparking concerns about its impact on brain function and emotional ...
Chemical multiplexing in the nervous system: molecular architecture, functional stratification, and pathophysiological plasticity of neuropeptide-classical neurotransmitter cotransmission [0.03%]
神经系统的化学复用：神经肽-经典神经递质共传递的分子架构、功能分层和病理生理可塑性
Adalberto Merighi,Marco Sbriz,Laura Lossi
Adalberto Merighi
Neurons frequently synthesize both neuropeptides and classical low-molecular-weight neurotransmitters, challenging the historical interpretation of one-neuron-one-transmitter signaling. Rather than representing biochemical redundancy, coexi...
Identification and validation of candidate biomarkers associated with mitochondria and 18 types of programmed cell death in trigeminal neuralgia: insights from transcriptome sequencing [0.03%]
三叉神经痛与线粒体及18种程序性细胞死亡相关的候选生物标志物的鉴定和验证：来自转录组测序的启示
Liqin Gao,Hongchen Shi,Lulu Xi et al.
Liqin Gao et al.
Background: Trigeminal neuralgia (TN) is relatively prevalent among the elderly population. Mitochondria-regulated programmed cell death has been identified as an important mechanism in the pathogenesis of a series of dis...
Comparative associations of the TyG index and HOMA2-IR with 6-month outcomes after moderate-to-severe traumatic brain injury: a single-center retrospective cohort study [0.03%]
葡萄糖胰岛素指数与HOMA2-IR在中重度创伤性脑损伤后的相关性及其预测功能预后的价值：一项单中心回顾性队列研究
Hai Zhao,Lingjuan Gao,Wei Wu et al.
Hai Zhao et al.
Background: The triglyceride glucose (TyG) index and the homeostatic model assessment 2 of insulin resistance (HOMA2-IR) are both valid markers for assessing insulin resistance (IR) and may serve as early metabolic biomar...
Editorial: Innovative approaches in glioma therapy: exploring new therapeutic frontiers, volume II [0.03%]
述评：胶质瘤治疗的创新策略——探索新的治疗前沿（第二部）
Pilar Marcos,Arturo Mangas,Rafael Coveñas
Pilar Marcos
Neurotransmitter co-transmission: synaptic architectures, functional logic, and emerging tools [0.03%]
神经递质共释放：突触结构、功能逻辑及新兴工具
Elif Tunc-Ozcan
Elif Tunc-Ozcan
Neurotransmitter co-transmission has become recognized as a fundamental organizing principle of neural communication, challenging the traditional view that individual neurons operate through a single transmitter system. Current evidence dem...
Sex differences in plasma endocannabinoids and related lipids before and after single and repeated mTBI: an exploratory study of endolipid plasma biomarkers [0.03%]
创伤性脑损伤前后的内源性大麻素和相关脂质的性别差异：关于内源性脂质血浆生物标志物的探索性研究
Emily Richter,Taylor J Woodward,Praveen P Kulkarni et al.
Emily Richter et al.
Sex differences in mild traumatic brain injury (mTBI) symptoms and severity are documented in both initial clinical presentation and long-term outcomes. Convergent data have demonstrated that the long-term outcomes for female patients with ...