The initiator of neuroexcitotoxicity and ferroptosis in ischemic stroke: Glutamate accumulation [0.03%]
缺血性卒中兴奋毒性及铁死亡的始动因素：谷氨酸堆积
Genhao Fan,Menglin Liu,Jia Liu et al.
Genhao Fan et al.
Glutamate plays an important role in excitotoxicity and ferroptosis. Excitotoxicity occurs through over-stimulation of glutamate receptors, specifically NMDAR, while in the non-receptor-mediated pathway, high glutamate concentrations reduce...
Exploring molecular signatures related to the mechanism of aging in different brain regions by integrated bioinformatics [0.03%]
整合生物信息学在不同脑区探索与衰老机制相关的分子标志物研究
Xie Su,Lu Xie,Jing Li et al.
Xie Su et al.
The mechanism of brain aging is not fully understood. Few studies have attempted to identify molecular changes using bioinformatics at the subregional level in the aging brain. This study aimed to identify the molecular signatures and key g...
Neural stem cell-derived extracellular vesicles favour neuronal differentiation and plasticity under stress conditions [0.03%]
神经干细胞源性细胞外囊泡在应激条件下有利于神经元分化和可塑性
Susana Delgado Ocaña,Dario Magaquian,Claudia Banchio
Susana Delgado Ocaña
Extracellular vesicles (EVs) are released by all cell types and are involved in intercellular communication. We evaluated if neural stem cells-derived EVs (NSC-EVs) regulate NSCs proliferation and differentiation under control and stress co...
Microglial activating transcription factor 3 upregulation: An indirect target to attenuate inflammation in the nervous system [0.03%]
小胶质细胞激活转录因子3的上调：缓解神经系统炎症的间接靶点
Seth D Holland,Matt S Ramer
Seth D Holland
Activating Transcription Factor 3 (ATF3) is upregulated in reaction to several cellular stressors found in a wide range of pathological conditions to coordinate a transcriptional response. ATF3 was first implicated in the transcriptional re...
Voltage-gated calcium channel subunit α2δ-1 in spinal dorsal horn neurons contributes to aberrant excitatory synaptic transmission and mechanical hypersensitivity after peripheral nerve injury [0.03%]
外周神经损伤后脊髓背角神经元电压门控钙通道辅助亚单位α2δ-1在异常兴奋性突触传递及机械性过敏中的作用
Keisuke Koga,Kenta Kobayashi,Makoto Tsuda et al.
Keisuke Koga et al.
Neuropathic pain, an intractable pain symptom that occurs after nerve damage, is caused by the aberrant excitability of spinal dorsal horn (SDH) neurons. Gabapentinoids, the most commonly used drugs for neuropathic pain, inhibit spinal calc...
Opening a window to the acutely injured brain: Simultaneous retinal and cerebral vascular monitoring in rats [0.03%]
同时监测大鼠视网膜血管和脑血管，探究急性脑损伤的发病机制
Laura Warner,Annika Bach-Hagemann,Tobias P Schmidt et al.
Laura Warner et al.
Many recent research projects have described typical chronic changes in the retinal vasculature for diverse neurovascular and neurodegenerative disorders such as stroke or Alzheimer's disease. Unlike cerebral vasculature, retinal blood vess...
Telemedicine efficacy and satisfaction of patients and headache specialists in migraine management [0.03%]
远程医疗在偏头痛管理中的有效性和患者及头痛专科医生的满意度
Qinlin Liu,Fang Liu,Xiran Yu et al.
Qinlin Liu et al.
Background: Migraine follow-up is difficult for outpatients, especially after the COVID-19 pandemic, we tried to identify the most appropriate telemedicine methods for migraine in terms of efficacy, safety, patient compli...
Involvement of endoplasmic reticulum stress in trigeminal ganglion corneal neuron injury in dry eye disease [0.03%]
干燥眼病中内质网应激参与三叉神经节角膜神经元损伤
Jinyu Zhang,Hongbin Lin,Fengxian Li et al.
Jinyu Zhang et al.
Dry eye disease (DED) is a multifactorial disease with a high prevalence worldwide. Uncomfortable corneal sensations severely affect daily life in DED patients. Hence, corneal neuron injury is a vital pathogenesis in DED. Notably, endoplasm...
Comparison of differential metabolites in brain tissue of aged marmosets and serum of elderly patients after prolonged anesthesia [0.03%]
长程麻醉后狨猴脑组织与老年患者血清差异代谢组对比研究
Fengwei Zhang,Haoli Mao,Jiao Zhu et al.
Fengwei Zhang et al.
Objective: To compare the differential metabolites in the brain tissue of aged marmosets after long-term anesthesia (≥ 6 h) and the serum of elderly patients by metabolomics methods. ...
Impaired interactions of ataxin-3 with protein complexes reveals their specific structure and functions in SCA3 Ki150 model [0.03%]
ATXN3互作蛋白复合体的异常揭示SCA3 Ki150模型中蛋白复合体的特定结构与功能
Piotr Piasecki,Kalina Wiatr,Milosz Ruszkowski et al.
Piotr Piasecki et al.
Spinocerebellar ataxia type 3 (SCA3/MJD) is a neurodegenerative disease caused by CAG expansion in mutant ATXN3 gene. The resulting PolyQ tract in mutant ataxin-3 protein is toxic to neurons and currently no effective treatment exists. Func...