Integrating neural organoids and AI: increasing the risk of artificial consciousness or medical malpractice? [0.03%]
神经器官与AI的整合：增加人工意识的风险还是医疗过失？
Alexander R Harris,Patrick McGivern,Kyle C A Wedgwood et al.
Alexander R Harris et al.
Neural organoids can be integrated with AI models in various formats, termed AI-NO systems. Neural organoids and AI are each high impact research fields which may play significant roles in biological research and clinical decision making. H...
Notch signaling inhibition attenuates epileptogenesis and hippocampal damage without altering mossy fiber sprouting in adolescent rats post-status epilepticus [0.03%]
诺特定理抑制减轻青少年期癫痫持续状态后的癫病化和海马损害但不影响苔鲜纤维侧支生长
Ping Yuan,Jin Chen,Li Jiang
Ping Yuan
Background: Notch overactivation and aberrant neurogenesis following status epilepticus (SE) has been identified by our previous study. The current study further supplements this by exploring additional pathological chang...
Clinical and genetic determinants of glioblastoma survival: a retrospective study [0.03%]
胶质母细胞瘤的临床和遗传决定因素：一项回顾性研究
Julia L Gutiérrez-Arroyo,Pia Gallego-Porcar,Elvira Carbonell-Martinez et al.
Julia L Gutiérrez-Arroyo et al.
Background: This study analyzed 57 patients with glioblastoma treated at the General University Hospital of Castellon, Spain, focusing on clinical, tumor-specific and genetic factors influencing disease outcome. Variables...
Wen Yang,Yu Xu,Kunhua Wang
Wen Yang
Lactate, traditionally regarded as a byproduct of glycolysis, has emerged as a key metabolic substrate and signaling molecule in the brain. Through the astrocyte-neuron lactate shuttle, lactate provides an essential link between energy meta...
Coactivation of CB1 and GPR55 promotes GABA release and motor behavior at striatonigral terminals through increased dimerization induced by CB1 activation [0.03%]
CB1和GPR55的偶联促进CB1激活引起的异二聚体增多，从而通过增加胆碱能释放来增强纹状体黑质终末板的运动行为
José Arturo Avalos-Fuentes,Rodolfo Sánchez-Zavaleta,Ihosvany Rodríguez Pérez et al.
José Arturo Avalos-Fuentes et al.
CB1 and GPR55 receptors form heteromers in striatal neurons; however, the effects of these heteromers on GABA release at their terminals and their impact on motor behavior remain unknown. In this study, we investigate the presence of CB1-GP...
Neuroplasticity and recovery of the brain affected by substance use disorder: multilevel mechanisms and new therapeutic strategies (2020-2025) [0.03%]
物质使用障碍影响下的脑可塑性和大脑恢复：多层次机制及新的治疗策略（2020-2025）
Roberto Estrada-Medina,Berle Estalin Briones-Llamoctanta,Josué Edison Turpo-Chaparro
Roberto Estrada-Medina
Introduction: Substance use disorder (SUD) is a complex neurobiological disorder characterized by the consolidation of maladaptive neuroplasticity affecting dopaminergic, glutamatergic, and neurotrophic systems, as well a...
Dysregulated lipid metabolism and hypomyelination in postnatal peroxisome-deficient Pex2 knockout Zellweger mice [0.03%]
过氧化物酶体缺陷型Pex2基因敲除Zellweger小鼠的脂质代谢紊乱和少髓鞘现象
Tanja Eberhart,Khanichi N Charles,Brenda Salumbides-Torres et al.
Tanja Eberhart et al.
Peroxisomes are dynamic organelles that play a crucial role in cellular metabolism, particularly in fatty acid degradation, cholesterol homeostasis and reactive oxygen species metabolism. Their dysfunction is associated with severe neurolog...
Mesenchymal stem cells and the central nervous system: historical perspectives and future directions [0.03%]
间充质干细胞与中枢神经系统：历史回顾及未来发展方向
Christopher Y Mazurek,Julia K Kaniuk,Christopher S Ahuja
Christopher Y Mazurek
Mesenchymal stem cells (MSCs) have been studied as a potential therapy for a wide range of conditions for approximately 30 years. MSCs have shown promise in treating pathologies of or affecting the central nervous system (CNS), specifically...
Temporal lobe epilepsy is associated with neuroinflammation, extracellular matrix remodeling, and synaptic protein alterations [0.03%]
颞叶癫痫与神经炎症、细胞外基质重塑和突触蛋白改变有关
Sophia Auer,Lucas Hoffmann,Martin Schicht et al.
Sophia Auer et al.
Introduction: Temporal lobe epilepsy is the most prevalent form of drug-resistant focal epilepsy and is frequently associated with neuronal cell loss and astrogliosis in the hippocampus, i.e. hippocampal sclerosis (HS). ...
T2-FLAIR hyperintensities in the inferior cerebellar peduncles and their association with clinical symptoms, molecular and MRI markers in male FMR1 premutation carriers [0.03%]
脆性X染色体综合征前突变携带者下小脑脚T2-FLAIR高信号及其与临床症状、分子和MRI标志物的关联研究
Andrea Elias-Mas,Irene Paracuellos-Ayala,Jun Yi Wang et al.
Andrea Elias-Mas et al.
Background and objectives: FMR1 premutation carriers (55-200 CGG repeats) are at risk of developing fragile X-associated tremor/ataxia syndrome (FXTAS), a neurodegenerative disorder associated with motor and cognitive imp...