Polymorphisms in methionine synthase, methionine synthase reductase and serine hydroxymethyltransferase, folate and alcohol intake, and colon cancer risk [0.03%]
叶酸、酒精摄入及甲基供体基因多态性与大肠癌发病危险性关系的研究
Susan E Steck,Temitope Keku,Lesley M Butler et al.
Susan E Steck et al.
Background/aims: We examined associations among folate and alcohol intake, single nucleotide polymorphisms (SNPs) in genes involved in one-carbon metabolism, and colon cancer risk. ...
Jing X Kang
Jing X Kang
Diets or nutritional supplements contain many nutrients and other components that may interact, which adds a layer of complexity to their evaluation. A well-controlled experimental model that can eliminate or minimize the confounding factor...
Transcriptional profiling of chromosome 17 quantitative trait Loci for carbohydrate and total calorie intake in a mouse congenic strain reveals candidate genes and pathways [0.03%]
染色体17定量性状位点的转录组分析揭示了碳水化合物和总热量摄入的小鼠共渗品系中的候选基因和信号通路
K Ganesh Kumar,Brenda K Smith Richards
K Ganesh Kumar
Background/aims: The genetic basis for ingestive behaviors is virtually unknown. Quantitative trait loci (QTLs) for carbohydrate and energy intake map to mouse chromosome 17 and were previously confirmed by a congenic str...
Catherine M Phillips,Audrey C Tierney,Helen M Roche
Catherine M Phillips
The metabolic syndrome (MetS) is a very common disease associated with an increased risk of type 2 diabetes mellitus and cardiovascular disease. The diverse clinical characteristics of the MetS illustrate the complexity of the disease proce...
Dietary modulators of peroxisome proliferator-activated receptors: implications for the prevention and treatment of metabolic syndrome [0.03%]
过氧化物酶体增殖激活受体的膳食调节剂在代谢综合征防治中的应用意义
Amir J Guri,Raquel Hontecillas,Josep Bassaganya-Riera
Amir J Guri
In its simplest form, obesity is a state characterized by nutrient overabundance leading to hypertrophy of storage cells in white adipose tissue and the deposition of excess lipids into key metabolic regions, such as skeletal muscle and liv...
Piya Lahiry,Rebecca L Pollex,Robert A Hegele
Piya Lahiry
The metabolic syndrome (MetS) is a commonly encountered cluster of clinical phenotypes, including central obesity, hypertension, hyperglycemia, and dyslipidemia. Identifying genetic determinants of MetS will lead to better understanding of ...
Andrea R Josse,David J A Jenkins,Cyril W C Kendall
Andrea R Josse
The metabolic syndrome has attracted interest because of its relevance to major contemporary chronic diseases associated with inactive lifestyles and the abundance of food, both of which have resulted in a way of life which challenges our g...
Josée Levesque,Benoît Lamarche
Josée Levesque
The metabolic syndrome (MetS) refers to the clustering of various metabolic risk factors that include abdominal obesity, dyslipidemia, hypertension, and hyperglycemia. It is now well known that it is associated with an increased risk of car...
Genetic and nutritional determinants of the metabolic syndrome: introduction [0.03%]
代谢综合征的基因和营养决定因素：介绍
Jean-Pierre Després,Louis Pérusse
Jean-Pierre Després
Fabio Verginelli,Federica Aru,Pasquale Battista et al.
Fabio Verginelli et al.
Bio-cultural adaptations to new foods played a key role in human evolution. The fossil record and sequence differences between human and chimpanzee genes point to a major dietary shift at the stem of human evolution. The earliest representa...