Preliminary evidence for genetic selection of 677T-MTHFR by natural annual cycle of folate abundance [0.03%]
叶酸年度循环对677T-MTHFR基因选择的初步证据
Mark Lucock,Zoë Yates,Xiaowei Ng et al.
Mark Lucock et al.
Background/aims: Folic acid mediates transfer of one-carbon units into methionine and DNA-thymine biosynthesis. Discretionary and mandatory use of synthetic folic acid (SFA) to reduce spina bifida is on the increase. We s...
Omega-3 fatty acids, inflammation and angiogenesis: nutrigenomic effects as an explanation for anti-atherogenic and anti-inflammatory effects of fish and fish oils [0.03%]
ω-3脂肪酸、炎症和血管生成：营养基因组学作用解释鱼及鱼油的抗动脉粥样硬化和抗炎效应
Marika Massaro,Egeria Scoditti,Maria Annunziata Carluccio et al.
Marika Massaro et al.
Atherosclerosis is a dynamic process with inflammatory aspects playing a considerable pathogenetic role. In this process, the vascular endothelium is the key regulator of vascular function, promoting the maintenance of vascular homeostasis ...
Regulation of low-density lipoprotein receptor and 3-hydroxy-3-methylglutaryl coenzyme A reductase gene expression by thymoquinone-rich fraction and thymoquinone in HepG2 cells [0.03%]
富噻嗪和塞来 quirone对HepG2细胞低密度脂蛋白受体和3-羟基-3甲基谷固醇辅酶A还原酶基因表达的调节作用
Ghanya Al-Naqeep,Maznah Ismail,Zeenathul Allaudin
Ghanya Al-Naqeep
Background and aim: Nigella sativa and its active constituent thymoquinone (TQ) have been exploited for their various health benefits. This work was aimed to investigate the regulatory effects of TQ-rich fraction (TQRF) a...
Commentary. Genetic variants and omega-6, omega-3 fatty acids: their role in the determination of nutritional requirements and chronic disease risk [0.03%]
述评. 基因变异与n-6、n-3型多不饱和脂肪酸：其在确定营养需求和慢性病风险中的作用
Artemis P Simopoulos
Artemis P Simopoulos
Omega-3 fatty acids, genetic variants in COX-2 and prostate cancer [0.03%]
ω-3脂肪酸以及前列腺素G/H合成酶2（PTGS2/COX-2）遗传变异与前列腺癌的关系
Adam C Reese,Vincent Fradet,John S Witte
Adam C Reese
Dietary intake of fish and omega-3 polyunsaturated fatty acids (omega-3 PUFAs) may decrease the risk of prostate cancer development and progression to advanced stage disease. This could reflect the anti-inflammatory effects of PUFAs, possib...
Polyunsaturated fatty acids and cardiovascular disease: implications for nutrigenetics [0.03%]
多不饱和脂肪酸与心血管疾病：营养基因组学的含义
Hooman Allayee,Nitzan Roth,Howard N Hodis
Hooman Allayee
Cardiovascular disease (CVD) arises as a result of genetic predisposition in the context of a disease-promoting environment. While several risk factors have been identified for CVD, such as elevated serum lipid levels and hypertension, most...
A 'desaturase hypothesis' for atherosclerosis: Janus-faced enzymes in omega-6 and omega-3 polyunsaturated fatty acid metabolism [0.03%]
动脉粥样硬化的“脱色酶假说”：n-6和n-3多不饱和脂肪酸代谢中具有双面神Janus作用的酶
Nicola Martinelli,Letizia Consoli,Oliviero Olivieri
Nicola Martinelli
The delta-5 and delta-6 desaturases are key enzymes in the metabolism of omega-3 (omega-3) and omega-6 (omega-6) polyunsaturated fatty acids (PUFA), which in turn influence cellular functions by regulating several metabolic pathways with we...
FADS gene cluster polymorphisms: important modulators of fatty acid levels and their impact on atopic diseases [0.03%]
脂肪酸水平的重要调节因子及其对特应性疾病的影响
Eva Lattka,Thomas Illig,Joachim Heinrich et al.
Eva Lattka et al.
Long-chain polyunsaturated fatty acids (LC-PUFAs) play an important role in several physiological processes and their concentration in phospholipids has been associated with several complex diseases, such as atopic disease. The level and co...
Anna Salas,Francesc Subirada,Miguel Pérez-Enciso et al.
Anna Salas et al.
Background/aims: Polyphenol compounds may explain most of the health-related beneficial effects of plants and vegetables, mainly through their antioxidant properties. The aim of the study was to assess the main changes on...
Interaction between familial history of obesity and fat intakes on obesity phenotypes [0.03%]
肥胖家族史与脂肪摄入对肥胖表型的交互作用
Ann-Marie Paradis,Gaston Godin,Louis Pérusse et al.
Ann-Marie Paradis et al.
Aim: To evaluate whether familial history of obesity (FHO) interacts with dietary fat intake (DFI) on obesity-related phenotypes. Methods: ...