TAS2R38 genotypes and phenylthiocarbamide bitter taste perception in a population of young adults [0.03%]
TAS2R38基因型与年轻人群苯硫甲胩苦味感知的关系
Nora H Khataan,Lindsay Stewart,Darren M Brenner et al.
Nora H Khataan et al.
Background/aims: TAS2R38 belongs to the TAS2R bitter taste receptor gene family and polymorphisms are associated with differences in bitter taste perception of phenylthiocarbamide (PTC) and 6-n-propylthiouracil (PROP). Th...
Edwin C M Mariman
Edwin C M Mariman
Despite considerable effort, genetic analysis of complex disorders and traits, including those related to nutrition, has revealed only a very small part of the expected genetic variation. Missing variation may occur as conditional variation...
Association of fatty acid desaturase gene polymorphisms with blood lipid essential fatty acids and perinatal depression among Canadian women: a pilot study [0.03%]
多不饱和脂肪酸代谢基因多态性与血脂、必需脂肪酸及围产期抑郁关系的前瞻性队列研究：加拿大女性试点研究结果
Lin Xie,Sheila M Innis
Lin Xie
Aims: The FADS1/FADS2 gene cluster encodes Delta-5 and Delta-6 desaturase, rate-limiting enzymes in metabolism of linoleic (LA) to arachidonic (ARA) and alpha-linolenic to eicosapentaenoic and docosahexaenoic acid (DHA). ...
Dopamine D2 receptor genotype (C957T) and habitual consumption of sugars in a free-living population of men and women [0.03%]
多巴胺D2受体基因型(C957T)与自由生活的男女习惯性摄入糖量的关系
Karen M Eny,Paul N Corey,Ahmed El-Sohemy
Karen M Eny
Background/aims: The dopamine D2 receptor (DRD2) has been implicated in modulating the rewarding effects of foods high in sugar. The purpose of this study was to determine whether a variation in the DRD2 gene affects habi...
Evidence of interaction between type 2 diabetes susceptibility genes and dietary fat intake for adiposity and glucose homeostasis-related phenotypes [0.03%]
2型糖尿病易感基因与膳食脂肪摄入交互作用的证据：针对肥胖及糖稳态相关表型
Stephanie-May Ruchat,Cathy E Elks,Ruth J F Loos et al.
Stephanie-May Ruchat et al.
Background/aims: Genome-wide association studies have led to the identification of several susceptibility genes for type 2 diabetes mellitus (T2DM). The objective of this study was to test the hypothesis that the associat...
Nutrition tailored to the individual? Not just yet - realigning nutrigenomic science with contemporary society [0.03%]
营养个体化？目前尚早——重塑符合当代社会的营养基因组学
Jop de Vrieze,Laura Bouwman,Rixt Komduur et al.
Jop de Vrieze et al.
About a decade ago, scientists and science journalists presented nutrigenomics as a grand promise that each of us would soon know which foods fit in our personal healthy diet. Meanwhile, expectations have been adjusted to fit a changed real...
Gene expression profiles in fetal and neonatal rat offspring of energy-restricted dams [0.03%]
能量限制母鼠后代胎鼠及新生鼠的基因表达谱分析
Mirella Hietaniemi,Merja Santaniemi,Elina Malo et al.
Mirella Hietaniemi et al.
Background/aims: Nutrition during fetal and early postnatal development can have permanent effects on physiology resulting in an increased risk for disease in later life. The aim of this study was to explore changes in ge...
Antonio Velázquez-Arellano,Sergio Encarnación
Antonio Velázquez-Arellano
With the advent of nutrigenomics, a more mechanistic view of the variable host responses to nutrients is beginning to emerge. Proteomics is central to nutrigenomics since studies on the effect of nutrients on the proteome have the potential...
Gene-nutrient interactions in G6PD-deficient subjects--implications for cardiovascular disease susceptibility [0.03%]
G6PD缺陷个体中的基因-营养相互作用及其对心血管疾病易感性的影响
Sergio Muntoni,Sandro Muntoni
Sergio Muntoni
Background/aims: The enzyme glucose-6-phosphate dehydrogenase (G6PD) is the principal source of reducing equivalents, necessary for regenerating reduced glutathione through NADPH in order to protect cells from oxidative d...
Role of calcitriol and cortisol on human adipocyte proliferation and oxidative and inflammatory stress: a microarray study [0.03%]
1,25-二羟基维生素D3和皮质醇对人脂肪细胞增殖及氧化和炎症应激的影响：微阵列研究
Xiaocun Sun,Kristin L Morris,Michael B Zemel
Xiaocun Sun
Dietary calcium inhibits adiposity, and a key underlying mechanism is suppression of calcitriol, which modulates Ca(2+) signaling and mitochondrial uncoupling in adipocytes. We demonstrated that calcitriol directly regulates adipocyte 11bet...