Gene expression of FTO in human subcutaneous adipose tissue, peripheral blood mononuclear cells and adipocyte cell line [0.03%]
FTO基因在人皮下脂肪组织、外周血单核细胞和脂肪细胞系中的表达
Tiina Lappalainen,Marjukka Kolehmainen,Ursula Schwab et al.
Tiina Lappalainen et al.
Background/aims: The common polymorphism rs9939609 of the fat mass and obesity-associated gene (FTO) is strongly associated with obesity, but the biological function is still unknown. We compared the FTO gene expression i...
Effect of Sauropus androgynus leaf extracts on the expression of prolactin and oxytocin genes in lactating BALB/C mice [0.03%]
Sauropus androgynus叶提取物对BALB/C小鼠泌乳期 prolactin和oxytocin基因表达的影响
Susan Soka,Herlina Alam,Novalia Boenjamin et al.
Susan Soka et al.
Sauropus androgynus is traditionally consumed by Indonesians and is believed to increase breast milk production during lactation. Lactation, a process of milk synthesis and secretion, occurs with the help of 2 hormones, prolactin and oxytoc...
Biotin starvation with adequate glucose provision causes paradoxical changes in fuel metabolism gene expression similar in rat (Rattus norvegicus), nematode (Caenorhabditis elegans) and yeast (Saccharomyces cerevisiae) [0.03%]
生物素缺乏伴充足葡萄糖供应可导致大鼠（Rattus norvegicus）、线虫（Caenorhabditis elegans）和酵母（Saccharomyces cerevisae）中与燃料代谢基因表达的反常变化类似的现象
D Ortega-Cuellar,A Hernandez-Mendoza,E Moreno-Arriola et al.
D Ortega-Cuellar et al.
Background/aim: Biotin affects the genetic expression of several glucose metabolism enzymes, besides being a cofactor of carboxylases. To explore how extensively biotin affects the expression of carbon metabolism genes, w...
Expression of genes involved in lipid metabolism in men with impaired glucose tolerance: impact of insulin stimulation and weight loss [0.03%]
与葡萄糖耐量受损男性有关的脂质代谢基因表达：胰岛素刺激和体重减轻的影响
E Konings,E Corpeleijn,F G Bouwman et al.
E Konings et al.
Background: The impaired glucose tolerance (IGT) state is characterized by insulin resistance. Disturbances in fatty acid (FA) metabolism may underlie this reduced insulin sensitivity. The aim of this study was to investi...
Paraoxonase 1 polymorphisms 172T→A and 584A→G modify the association between serum concentrations of the antioxidant lycopene and bone turnover markers and oxidative stress parameters in women 25-70 years of age [0.03%]
paraoxonase 1基因多态性172T→A和584G→A修饰了番茄红素与骨代谢标志物及氧化应激参数之间的关系（25～70岁女性）
E S Mackinnon,A El-Sohemy,A V Rao et al.
E S Mackinnon et al.
Background/aims: Polymorphisms of the paraoxonase 1 (PON1) enzyme affect the ability to protect LDL from oxidation. Oxidative stress is a risk factor for osteoporosis and antioxidants may be beneficial for prevention. The...
Vitamin C transporter gene polymorphisms, dietary vitamin C and serum ascorbic acid [0.03%]
维生素C转运基因多态性、膳食维生素C和血清抗坏血酸水平
Leah E Cahill,Ahmed El-Sohemy
Leah E Cahill
Background/aims: Vitamin C transporter proteins SVCT1 and SVCT2 are required for the absorption and transport of vitamin C in humans. This study aims to determine whether common SVCT genotypes modify the association betwe...
An 8-week high-fat diet induces obesity and insulin resistance with small changes in the muscle transcriptome of C57BL/6J mice [0.03%]
高脂饮食诱导小鼠肥胖及肌肉基因表达变化研究
Janneke de Wilde,Egbert Smit,Ronny Mohren et al.
Janneke de Wilde et al.
Background: Skeletal muscle is responsible for most of the insulin-stimulated glucose uptake and metabolism. Therefore, it plays an important role in the development of insulin resistance, one of the characteristics of th...
Polyunsaturated fatty acids, DNA repair single nucleotide polymorphisms and colorectal cancer in the Singapore Chinese Health Study [0.03%]
新加坡华人健康研究中的多不饱和脂肪酸、DNA修复单核苷酸多态性与结直肠癌
Mariana C Stern,Lesley M Butler,Román Corral et al.
Mariana C Stern et al.
Animal and in vitrostudies support a role for polyunsaturated fatty acids (PUFAs) in colon carcinogenesis; however, the epidemiological evidence is inconclusive. Recently, we investigated their role within the Singapore Chinese Health Study...
A high-sucrose isocaloric pair-fed model induces obesity and impairs NDUFB6 gene function in rat adipose tissue [0.03%]
高蔗糖等热量配对喂养模型诱导大鼠脂肪组织肥胖并影响NDUFB6基因功能
A Lomba,F I Milagro,D F García-Díaz et al.
A Lomba et al.
Background/aim: Changes in dietary macronutrient content are involved in altered energy metabolism and obesity development. However, there are controversial views about the obesogenic effects of high-sucrose (HS) diets, w...