mRNA expression analysis and the molecular basis of neonatal testis defects in Dmrt1 mutant mice [0.03%]
Dmrt1突变小鼠新生儿睾丸缺陷的基因表达分析及分子机理研究
U Fahrioglu,M W Murphy,D Zarkower et al.
U Fahrioglu et al.
Transcriptional regulators containing the DM domain DNA binding motif have been found to control sexual differentiation in a diverse group of metazoan animals including vertebrates, insects, and nematodes, suggesting that these proteins may...
Familial translocation t(1;9) associated with macromastia: molecular cloning of the breakpoints [0.03%]
与巨乳症相关的家族易位t(1;9)断裂点的分子克隆
P Wieacker,N Apeshiotis,S Jakubiczka et al.
P Wieacker et al.
A familial reciprocal translocation associated with severe macromastia has been characterized by molecular cytogenetic and molecular analysis. Cloning of the translocation breakpoints revealed that no known gene has been disrupted by this t...
Extended pedigree with multiple cases of XX sex reversal in the absence of SRY and of a mutation at the SOX9 locus [0.03%]
在没有SRY和SOX9基因位点突变的情况下多个XX性别反转病例的扩延家系
S G Temel,T Gulten,T Yakut et al.
S G Temel et al.
It is well established that testicular differentiation of the human embryonic gonad depends on the action of the Y-chromosomal gene SRY. However, exceptional cases such as SRY-negative cases of 46,XX testicular disorder of sexual developmen...
T Svingen,P Koopman
T Svingen
In eutherian mammals, sexual development hinges on the differentiation of the gonadal primordia into either testes or ovaries, in turn determined by the activity of the Y-linked gene Sry. Organogenesis of the gonads requires input from a co...
The evolution of sex chromosomes and sex determination in vertebrates and the key role of DMRT1 [0.03%]
脊椎动物性染色体和性别决定的进化及DMRT1的关键作用
M Ferguson-Smith
M Ferguson-Smith
Mechanisms of vertebrate sex determination are reviewed in the light of what is known about the origin and evolution of sex chromosomes. All vertebrate males have testes that are similar in anatomy and in spermatogenesis. Despite a variety ...
Analysis of Functional Cis-regulatory Elements Reveals Novel Transcriptional Regulatory Mechanisms in Gonadal Development [0.03%]
功能顺式调控元件分析揭示生殖腺发育中的新转录调控机制
Recent studies have demonstrated that the production of bidirectional enhancer-derived transcripts (eRNAs) is a characteristic of an active Cis-regulatory element (CRE). Higher levels of eRNA synthesis correlate with the activation of histo...