Kelly K Andringa,Anupam Agarwal
Kelly K Andringa
Oxygen is vital to mammalian survival. Oxygen deprivation, defined as hypoxia, elicits adaptive responses in cells and tissues, a process regulated by proteins known as hypoxia-inducible factors (HIF). Animal studies have provided compellin...
Didier Portilla
Didier Portilla
Fibrosis is a major hallmark of progressive kidney disease. The cellular mechanisms that lead to kidney tissue fibrosis are complex and include, for example, increased inflammation, increased oxidative stress, and proximal tubule cell death...
Joseph V Bonventre
Joseph V Bonventre
Acute kidney injury (AKI) leads to worsening of chronic kidney disease (CKD), and CKD predisposes to the clinical entity of AKI. The tubules of the kidney play a central role in the fibrotic response, which ultimately leads to progressive k...
Liyu He,Man J Livingston,Zheng Dong
Liyu He
Acute kidney injury (AKI) is a major kidney disease associated with a poor clinical outcome both in the short and long term. Autophagy is a cellular stress response that plays important roles in the pathogenesis of various diseases. Autopha...
M N Martina,S Noel,S Bandapalle et al.
M N Martina et al.
The immune system is among the key pathogenic factors in acute kidney injury (AKI). Various immune cells, including dendritic cells, natural killer T cells, T and B lymphocytes, neutrophils and macrophages are involved. Conventional CD4+ ly...
Progression from acute kidney injury to chronic kidney disease: clinical and experimental insights and queries [0.03%]
从急性肾损伤到慢性肾脏病的进展：临床和实验观点与疑问
Richard A Zager
Richard A Zager
There is an increasing number of clinical studies suggesting that acute kidney injury (AKI) can be complicated by the onset of progressive renal disease. Indeed, given the frequency of AKI in hospitalized patients, it could potentially be a...
Mei Tran,Samir M Parikh
Mei Tran
Mitochondrial dysfunction within the tubular epithelium has been implicated in the pathogenesis of acute kidney injury. Inflammatory, ischemic, or toxic insults dysregulate mitochondrial dynamics, resulting in mitochondrial swelling, fissio...
Effects of renal replacement therapy on renal recovery after acute kidney injury [0.03%]
肾替代治疗对急性肾损伤后肾功能恢复的影响
Antoine G Schneider,Sean M Bagshaw
Antoine G Schneider
Recovery of kidney function following an episode of acute kidney injury (AKI) is now acknowledged as a vital patient-centered outcome with clear health economic implications. In approximately 5-8% of critically ill patients with more severe...
Michael Heung,Lakhmir S Chawla
Michael Heung
This review examines the evidence linking acute kidney injury (AKI) with the risk of subsequently developing chronic kidney disease (CKD). The discussion focuses on subjects that recover from an episode of AKI, most of whom do not receive f...
Mélanie Godin,Etienne Macedo,Ravindra L Mehta
Mélanie Godin
Acute kidney injury (AKI) is associated with increased mortality, prolonged hospitalization, and renal replacement therapy. Until recently, it was believed that the vast majority of patients recover from AKI without subsequent consequences....